Abstract: Disclosed are methods and compositions for treating CTNNB1 syndrome. The disclosed methods and compositions may utilize or comprise a glycogen synthase kinase 3 (GSK3) inhibitor, or a pharmaceutically acceptable salt thereof. The GSK3 inhibitor may comprise small molecules such as substituted tricyclic pyrazolo-tetrahydroquinolinones, and the GSK3 inhibitor may selectively inhibit GSK3? and GSK3? or dually inhibit GSK3? and GSK3?.

Abstract: A mobile light exposure device that delivers light pulses to a plant material has a first emission module that has at least one light treatment panel configured to emit one or more light pulses; has a second module configured for adjusting and/or switching on an optical power density of the light treatment panel and optionally a temperature of the light treatment panel; and has a locomotive means for moving the mobile light exposure device. In operation, the mobile light exposure device attenuates impacts on plant material associated with abiotic stresses, such as stresses associated with edaphic, climatic and/or chemical factors.

Abstract: There is described a terahertz illumination source for terahertz imaging.

Abstract: There is described a terahertz illumination source for terahertz imaging.

Abstract: Method and system for emitting optical pulses in view of a desired output energy of the optical pulses and a variable external trigger signal, using a laser system having a seed laser oscillator optically coupled to one or more cascaded optical amplification stages. For each amplification stage, a plurality of sets of pump pulse parameters are provided, each associated with specific values of the output energy and the trigger period. Proper pumping parameters associated with the received desired value of the output energy and the trigger period of the received trigger signal are selected for each amplification stage, which is pumped accordingly before a seed optical pulse is launched through the system.

Abstract: Method and system for emitting optical pulses in view of a desired output energy of the optical pulses and a variable external trigger signal, using a laser system having a seed laser oscillator optically coupled to one or more cascaded optical amplification stages. For each amplification stage, a plurality of sets of pump pulse parameters are provided, each associated with specific values of the output energy and the trigger period. Proper pumping parameters associated with the received desired value of the output energy and the trigger period of the received trigger signal are selected for each amplification stage, which is pumped accordingly before a seed optical pulse is launched through the system.

Abstract: A digital pulse shaping module provides a digital waveform such as a pulse shape, gating or a synchronizing digital signal for use with a pulsed laser oscillator. The digital pulse shaping module includes a waveform data generator that generates N-bit words having a number N of bits. A serializer is further provided to receive the N-bit words from the waveform data generator and outputs each bit individually in a series of bits corresponding to the digital waveform. The digital pulse shaping module further includes a delay module that provides a fine delay in the outputting of the bits by the serializer. This fine delay corresponds to a number of bits smaller than N, impacting on the timing of the outputted signal at the bit level. A pulse shaping generator has a plurality of digital pulse shaping modules.

Abstract: One aspect of the present invention is a method of checking access rights in a mobile radio system, comprising steps whereby: a core network serving entity receives from a mobile user database different types of authentication data according to the type of services authorized for said users, and said serving entity uses said authentication data to check the access rights of said users according to the type of services authorized.

Abstract: A circuit assembly controlling an optical system to generate optical pulses is provided. The optical system includes a seed light source optically coupled to an amplitude modulator. The circuit assembly includes a control circuit which generates a pulsed seed drive signal for driving the seed laser source, as well as logic signals defining successions of ON and OFF states and having a predetermined relative timing relationship. One or more of the logic signals is delayed by a corresponding programmable delay line to adjust the relative timing relationship between the logic signals. A logic gating module combines the logic signals according to one or more logical rule, thereby providing a modulator drive signal. Using this circuit assembly, the optical system outputs an optical pulse at each ON state of the modulator drive signal synchronized with the passage of one of the seed optical pulses through the amplitude modulator.

Abstract: A circuit assembly controlling an optical system to generate optical pulses is provided. The optical system includes a seed light source optically coupled to an amplitude modulator. The circuit assembly includes a control circuit which generates a pulsed seed drive signal for driving the seed laser source, as well as logic signals defining successions of ON and OFF states and having a predetermined relative timing relationship. One or more of the logic signals is delayed by a corresponding programmable delay line to adjust the relative timing relationship between the logic signals. A logic gating module combines the logic signals according to one or more logical rule, thereby providing a modulator drive signal. Using this circuit assembly, the optical system outputs an optical pulse at each ON state of the modulator drive signal synchronized with the passage of one of the seed optical pulses through the amplitude modulator.

Abstract: A digital pulse shaping module provides a digital waveform such as a pulse shape, gating or a synchronizing digital signal for use with a pulsed laser oscillator. The digital pulse shaping module includes a waveform data generator that generates N-bit words having a number N of bits. A serialiser is further provided to receive the N-bit words from the waveform data generator and outputs each bit individually in a series of bits corresponding to the digital waveform. The digital pulse shaping module further includes a delay module that provides a fine delay in the outputting of the bits by the serialiser. This fine delay corresponds to a number of bits smaller than N, impacting on the timing of the outputted signal at the bit level. A pulse shaping generator has a plurality of digital pulse shaping modules.

Abstract: A digital pulse shaping module for controlling a pulsed laser oscillator according to a digital input waveform is provided. The pulse shaping module includes a clock generator generating a plurality of phase-related clock signals and a shape generator which outputs a digital shape signal corresponding to the digital input waveform in Double Data Rate in response to the clock signals. A DAC converts the digital shape into an analog shape signal. The analog shape signal may be used to control the current source of a laser seed source or modulators in the laser oscillator shaping a seed light signal. Optionally, the pulse shaping module may also output a gate control signal having a predetermined timing relationship with respect to the digital shape signal.

Abstract: A driver circuit for a laser diode provides drive signals to the electrodes of the laser diode based on a pulsed input signal. An input receives the pulsed input signal and launches it into an amplification stage which preferably includes dual amplifiers, a buffering stage and a biasing stage. The output of the laser diode is an optical signal that reproduces the pulsed input signal with high fidelity and low amplitude noise. In one embodiment, the input separates the pulsed input signal into two signal components, launched in respective inverting and non-inverting branches which each include successive amplification, buffering and biasing stages.

Abstract: A digital pulse shaping module for controlling a pulsed laser oscillator according to a digital input waveform is provided. The pulse shaping module includes a clock generator generating a plurality of phase-related clock signals and a shape generator which outputs a digital shape signal corresponding to the digital input waveform in Double Data Rate in response to the clock signals. A DAC converts the digital shape into an analog shape signal. The analog shape signal may be used to control the current source of a laser seed source or modulators in the laser oscillator shaping a seed light signal. Optionally, the pulse shaping module may also output a gate control signal having a predetermined timing relationship with respect to the digital shape signal.

Abstract: A footwear closure assembly and method including multiple closure systems that may be selected from by a wearer including a first closure device having a removable cord and openings for receiving the cord to secure closure of the footwear; and a second closure device including a removable strap and slots for receiving the strap. The closure assembly is provided such that the wearer may select from among the various closure devices including the first closure device, the second closure device, or both first and second closure devices providing increased versatility for the wearer.

Abstract: One aspect of the present invention is a method of checking access rights in a mobile radio system, comprising steps whereby: a core network serving entity receives from a mobile user database different types of authentication data according to the type of services authorized for said users, and said serving entity uses said authentication data to check the access rights of said users according to the type of services authorized.

Abstract: The present invention relates to genetically modified plants and plant cells, comprising nucleotide sequences encoding heterologous heavy metal transport protein.

Abstract: A footwear closure assembly and method includes a plurality of eyelets and at least one pair of slots disposed in said footwear, a cord received by the eyelets and at least one strap to be received by the slots, each strap having fasteners at each of its ends disposed on opposite surfaces of said ends. Closure is achieved by use of cord-alone, strap-alone, or both cord and strap in combination.

Abstract: The invention relates to a device for controlling the variation of the power and/or the speed of a load (2), such as an asynchronous, synchronous, universal motor, a transformer, an inductance, a condenser or a resistor, comprising a switch (5) placed on a phase (4) of a single-phase or multiphase alternating-current supply-circuit (3), this switch (5) being associated with means (6) for controlling the cyclic ratio .alpha./T in which .alpha. corresponds to the time of opening and closing of the circuit (3) by the switch (5) and T to the period of the phase (4) on which this latter is placed. In fact, the switch (5) is of the bidirectional MOS, IGBT or bipolar transistor switch type, this switch (5) being associated with means (9) for controlling the switching time, of the DRIVER type, capable of extending the switching time at closing so that it be within a range from 10 microseconds to 1 millisecond.