Abstract: The present invention relates to a method for preparing 2-[2-(2-chlorothiazol-5-yl)-2- hydroxy-ethyl]sulfanyl-6-hydroxy-3-methyl-5-phenyl-pyrimidin-4-one or a tautomer thereof or enantiomerically enriched forms thereof, to 2-[2-(2-chlorothiazol-5-yl)-2-hydroxy-ethyl]sulfanyl-6-hydroxy-3-methyl-5-phenyl-pyrimidin-4-one or a tautomer thereof or enantiomerically enriched forms thereof, and to the use thereof as intermediate in the preparation of 2,3-dihydrothiazolo[3,2-a]pyrimidinium compounds, specifically of 3-(2-chlorothiazol-5-yl)-8-methyl-7-oxo-6-phenyl-2,3-dihydrothiazolo [3,2-a]pyrimidin-4-ium-5-olate and enantiomerically enriched forms thereof.

Abstract: The present invention relates to a method for preparing 2-[2-(2-chlorothiazol-5-yl)-2-oxo-ethyl]sulfanyl-6-hydroxy-3-methyl-5-phenyl-pyrimidin-4-one or a tautomer thereof, to 2-[2-(2-chlorothiazol-5-yl)-2-oxo-ethyl]sulfanyl-6-hydroxy-3-methyl-5-phenyl-pyrimidin-4-one or a tautomer thereof and to its use as intermediate in the preparation of 2,3-dihydrotheiazolo [3,2-a]pyrimidinium compounds, and specifically of 3-(2-chlorothiazol-5-yl)-8-methyl-7-oxo-6-phenyl-2,3-dihydrothiazolo [3,2-a]pyrimidin-4-ium-5-olate and enantiomerically enriched forms thereof.

Abstract: The present invention relates to an immunocytokine comprising (a) a conjugate, and (b) an antibody or a fragment thereof directly or indirectly linked by covalence to said conjugate, wherein said conjugate comprises (i) a polypeptide comprising the amino acid sequence of the interleukin 15 or derivatives thereof, and (ii) a polypeptide comprising the amino acid sequence of the sushi domain of the interleukin 15R alpha (IL-15R?) or derivatives thereof; and uses thereof.

Abstract: A coiling limitation device for a timepiece barrel includes at least one non-return notch arranged to cooperate with a sliding flange of the spring of the barrel, which is integrated in a watch including a resonator cooperating with an escapement mechanism. This device includes an acoustic device for the acoustic monitoring of the coiling of the barrel of a watch positioned on a receptacle included by the device, which acoustic devices are arranged to identify a click noise during each start of cooperation between the sliding flange and a notch. The device includes piloting devices arranged to stop the coiling of the barrel at the instant of the perception of the click noise or the repetition of the click noise.

Abstract: The present invention relates to a process for the preparation of substituted 4-(N?-hydroxy-carbamimidoyl)benzoic acids, which can be obtained by nitrilase catalyzed hydration of substituted terephthalonitriles of formula (II) in an aqueous medium to afford (ammonium) 4-cyanobenzoic acids (IIa). The hydration is followed by treatment of the aqueous reaction medium with hydroxylamine or a salt thereof to afford amidoximes (I).

Abstract: A method for monitoring an aircraft component, including the following steps: receiving, from a video acquisition device, a video stream that represents at least one portion of the component; in the event that the realization of a predetermined condition is detected, extracting a portion of the video stream to form a sequence of interest; identifying, within the extracted sequence of interest, at least one image of interest; including a signature, obtained using each image of interest, with at least one predetermined signature from a library of signatures; and generating an anomaly detection signal if the result of the comparison meets a predetermined criterion.

Abstract: The invention relates to a method for detecting a possible fuel leak into an oil circuit of an aircraft engine, the aircraft including at least one pair of identical engines equipped with respective oil circuits, the pair of engines being associated with at least one quadruplet of measurements previously acquired in a measurement time during the operation of the engines of the pair and corresponding to a measurement of pressure and a measurement of temperature of the fluid contained in each of the oil circuits of the engines of the pair.

Abstract: Methods of performing a stimulation operation at a wellsite are disclosed. The wellsite is positioned about a subterranean formation having a wellbore therethrough and zones thereabout. The method involves establishing at least one objective for stimulating production of reservoir fluid from the subterranean formation and into the wellbore. The stimulating involves placing a stimulating fluid along the zones of the wellbore. The objective is based on wellsite data. The method also involves identifying at least one constraint for the stimulating, determining target distributions of the stimulation fluid based on the objective(s) and the constraint(s), and selecting operational parameters for the stimulating based on the constraint(s) and the target distributions. The method may also involve stimulating the subterranean formation using the target distributions and the operational parameters, monitoring the wellsite during the stimulating, and adjusting the stimulating based on the monitoring.

Abstract: Modular connectivity and power management systems and associated devices and methods are disclosed herein. A modular system configured in accordance with implementations of the present technology can include, for example, a housing, a display, and a single, active printed circuit board including a variety of connectivity and energy management devices electrically coupled thereto. In some implementations, the printed circuit board can include a microprocessor, a micro controller, a power management system, a plurality of communication devices, and a USB port. The modular system can include an internal battery, an external battery, and can be configured to directly connect to a solar panel and/or a DC power source. The modular system can be configured to charge the internal battery before charging the external battery and/or can be configured to use power stored on the external battery before using power stored on the internal battery.

Abstract: An extruder assembly for forming a multi-layered composite is described, the extruder assembly includes an extruder head having a first and second flow passage, a first and second extruder in fluid communication with the respective first and second flow passage, and a splice bar having a first and second passageway extending from a rear side to an outlet side, and communicating flow from the first and second passageway to an outlet die. The splice bar further includes a groove located on the rear side of the splice bar and being positioned between the first and second passageway.

Abstract: The turbine (1) has a rotor (2) with blades (4) arranged on a periphery of disks (5) in radial planes (3), and a tie rod (6) extending along slots (7) in the disks. An annular spacer (15, 15?) fixes a position of the tie rod relative to a center line (M) of the disks, and is arranged in a channel (10, 11). The spacer has through-openings, which are arranged radially relative to the tie rod or to its center line, and extend coaxially. The channel carries a cooling medium and is limited by a separating pipe (13, 14) radially outwards. The through-openings serve for flow of the medium.

Abstract: An igniter plug for an aircraft turbomachine includes an external electrode, an internal electrode, as well as a semiconducting body arranged between the external electrode and the internal electrode and set back from these electrodes so as to define an electrical arc forming cavity, the bottom of which is formed by an axial end surface of the semiconducting body. The free end of the external electrode is equipped with at least one scoop for discharging possible fuel residues present in the cavity.

Abstract: An extruder assembly for forming a multi-layered composite is described, the extruder assembly includes an extruder head having a first and second flow passage, a first and second extruder in fluid communication with the respective first and second flow passage, and a splice bar having a first and second passageway extending from a rear side to an outlet side, and communicating flow from the first and second passageway to an outlet die the splice bar further includes a groove located on the rear side of the splice bar and being positioned between the first and second passageway.

Abstract: The invention relates to a turbomachine (30) comprising: a compressor stage and a turbine stage, each stage comprising at least one disk (42); and a tubular shaft (31) sleeve (33) extending along the axis (32) of the turbomachine, wherein the sleeve (33) comprises at least one tab (40) extending from an outer radial surface (41) of the sleeve and facing the disk (42), the tab (40) being designed to come into contact with the disk (42) when the sleeve (33) is in rotation about the axis (32) of the turbomachine.

Abstract: Monitoring a user's exposure to ultraviolet radiation, including determining the amount of radiation to which the user is exposed from different directions, respectively.

Abstract: Monitoring a user's exposure to ultraviolet radiation, including determining the amount of radiation to which the user is exposed from different directions, respectively.

Abstract: The invention relates to a trunnion (23) for a high-pressure turbine (11), to be arranged between a shaft of a low-pressure turbine (9) and an inner surface (34) of a seal mounting (26) of the low-pressure turbine (8), the trunnion (23) being characterised in that it includes a drop-launching extension (32) arranged such as to extend opposite a flared portion (33) of the inner surface (34) of the seal mounting (26), such that when the trunnion (23) is rotated about the shaft of the low-pressure turbine (9), oil (H2), which tends to penetrate between the trunnion (23) and the seal mounting (26), is thrown by centrifugal effect from the drop-launching extension (32) toward the flared portion (33) of the inner surface (34) of the seal mounting (26).

Abstract: Monitoring a user's exposure to ultraviolet radiation, including determining the amount of radiation to which the user is exposed from different directions, respectively.

Abstract: Monitoring a user's exposure to ultraviolet radiation, including determining the amount of radiation to which the user is exposed from different directions, respectively.

Abstract: The invention relates to an igniter plug (30) for an aircraft turbomachine, comprising an external electrode (34), an internal electrode (36), as well as a semiconducting body (38) arranged between the external electrode and the internal electrode and set back from these electrodes so as to define an electrical arc forming cavity (40), the bottom of which is formed by an axial end surface (42) of the semiconducting body. According to the invention, the end of the external electrode (34) is equipped with at least one scoop (44) for discharging possible fuel residues present in the cavity (40).