Patents by Inventor Michel Kliot

Michel Kliot has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200397326
    Abstract: The provided systems, methods and devices describe lightweight, wireless tissue monitoring devices that are capable of establishing conformal contact due to the flexibility or bendability of the device. The described systems and devices are useful, for example, for skin-mounted intraoperative monitoring of nerve-muscle activity. The present systems and methods are versatile and may be used for a variety of tissues (e.g. skin, organs, muscles, nerves, etc.) to measure a variety of different parameterps (e.g. electric signals, electric potentials, electromyography, movement, vibration, acoustic signals, response to various stimuli, etc.).
    Type: Application
    Filed: February 22, 2019
    Publication date: December 24, 2020
    Inventors: John A. ROGERS, Michel KLIOT, Roozbeh GHAFFARI, YuHao LIU
  • Publication number: 20160262731
    Abstract: A nerve stimulation biopsy device configured to deliver a precise and adjustable stimulus signal into a biopsy site. The stimulus signal is used to distinguish between functioning nerve fibers and target tissue. Also disclosed is a method for safely performing a biopsy procedure on a biopsy site of a patient, which utilizes introducing a stimulus signal to the biopsy site.
    Type: Application
    Filed: March 9, 2016
    Publication date: September 15, 2016
    Inventors: Michel Kliot, John Bode, Michael Heiferman, Ryan Khanna, Yunli Ma, Komal Prem, Nick Messana, Colin Russi
  • Publication number: 20140039279
    Abstract: Methods and systems for identifying and spatially localizing tissues having certain physiological properties or producing certain biological responses, such as the sensation of pain, in response to the application of intense focused ultrasound (acoustic probing or palpation) are provided. In some embodiments, targeted acoustic probing is employed to identify the scope and severity of chronically painful sensitized tissue areas, and of chronic pain disorders. In other applications, targeted acoustic probing is used to localize nerves and other sensitized tissues for guidance of needles and other delivery devices, and for delivery of anesthetic, analgesic or therapeutic compositions.
    Type: Application
    Filed: October 10, 2013
    Publication date: February 6, 2014
    Applicants: UNIVERSITY OF WASHINGTON, PHYSIOSONICS, INC.
    Inventors: Jeffrey G. Jarvik, Pierre Mourad, Michel Kliot, Robert C.A. Frederickson, Abbi M McClintic, Trevor C. Dickey, Michael Gofeld
  • Publication number: 20120108918
    Abstract: Methods and systems for identifying and spatially localizing tissues having certain physiological properties or producing certain biological responses, such as the sensation of pain, in response to the application of intense focused ultrasound (acoustic probing or palpation) are provided. In some embodiments, targeted acoustic probing is employed to identify the scope and severity of chronically painful sensitized tissue areas, and of chronic pain disorders. In other applications, targeted acoustic probing is used to localize nerves and other sensitized tissues for guidance of needles and other delivery devices, and for delivery of anesthetic, analgesic or therapeutic compositions.
    Type: Application
    Filed: June 15, 2011
    Publication date: May 3, 2012
    Applicant: PHYSIOSONICS, INC.
    Inventors: Jeffrey G. Jarvik, Pierre D. Mourad, Michel Kliot, Robert C.A. Frederickson, Abbi M. McClintic, Trevor C. Dickey, Michael Gofeld
  • Patent number: 7815574
    Abstract: Systems and methods for noninvasive assessment of cardiac tissue properties and cardiac parameters using ultrasound techniques are disclosed. Determinations of myocardial tissue stiffness, tension, strain, strain rate, and the like, may be used to assess myocardial contractility, myocardial ischemia and infarction, ventricular filling and atrial pressures, and diastolic functions. Non-invasive systems in which acoustic techniques, such as ultrasound, are employed to acquire data relating to intrinsic tissue displacements are disclosed. Non-invasive systems in which ultrasound techniques are used to acoustically stimulate or palpate target cardiac tissue, or induce a response at a cardiac tissue site that relates to cardiac tissue properties and/or cardiac parameters are also disclosed.
    Type: Grant
    Filed: March 31, 2006
    Date of Patent: October 19, 2010
    Assignees: PhysioSonics, Inc., University of Washington
    Inventors: Pierre D. Mourad, Michel Kliot, Rex Patterson, Alec Rooke
  • Publication number: 20100087728
    Abstract: Methods and systems for identifying and spatially localizing tissues having certain physiological properties or producing certain biological responses, such as the sensation of pain, in response to the application of intense focused ultrasound (acoustic probing or palpation) are provided. In some embodiments, targeted acoustic probing may be guided or visualized using imaging techniques such as ultrasound imaging or other types of non-invasive imaging techniques.
    Type: Application
    Filed: September 18, 2009
    Publication date: April 8, 2010
    Applicants: PHYSIOSONICS, INC., UNIVERSITY OF WASHINGTON
    Inventors: Jeffrey G. JARVIK, Pierre D. MOURAD, Michel KLIOT, Robert C. A. FREDERICKSON
  • Publication number: 20100081893
    Abstract: Methods and systems for identifying and spatially localizing tissues having certain physiological properties or producing certain biological responses, such as the sensation of pain, in response to the application of intense focused ultrasound (acoustic probing or palpation) are provided. In some embodiments, targeted acoustic probing may be guided or visualized using imaging techniques such as ultrasound imaging or other types of non-invasive imaging techniques.
    Type: Application
    Filed: September 18, 2009
    Publication date: April 1, 2010
    Applicants: PHYSIOSONICS, INC., UNIVERSITY OF WASHINGTON
    Inventors: Jeffrey G. JARVIK, Pierre D. MOURAD, Michel KLIOT, Robert C. A. FREDERICKSON
  • Patent number: 7547283
    Abstract: Systems and methods for determining ICP based on parameters that can be measured using non-invasive or minimally invasive techniques are provided, wherein a non-linear relationship is used to determine ICP based on one or more variable inputs. The first variable input relates to one or more properties of a cranial blood vessel and/or blood flow, such as acoustic backscatter from an acoustic transducer having a focus trained on a cranial blood vessel, flow velocity in a cranial blood vessel, and the like. Additional variables, such as arterial blood pressure (ABP), may be used in combination with a first variable input relating to one or more properties of a cranial blood vessel, such as flow velocity of the middle cerebral artery (MCA) to derive ICP using a non-linear relationship.
    Type: Grant
    Filed: June 3, 2004
    Date of Patent: June 16, 2009
    Assignee: PhysioSonics, Inc.
    Inventors: Pierre D. Mourad, Brandt Mohr, Michel Kliot, Robert C. A. Frederickson
  • Publication number: 20090149751
    Abstract: Systems and methods for determining ICP based on parameters that can be measured using non-invasive or minimally invasive techniques are provided. Systems for acquiring acoustic data from a desired target site in a subject's body using various types of acoustic source and detector elements are also provided, including single use acoustic source/detector combinations are also provided. Acoustic arrays for use with these systems may include multiple capacitive micro-machined ultrasound transducer (cMUT) elements, and may include a combination of different types of acoustic arrays. Methods of targeting localized sites within a broad target area based on acoustic data having various properties are also disclosed.
    Type: Application
    Filed: December 1, 2008
    Publication date: June 11, 2009
    Applicants: PHYSIOSONICS, INC., UNIVERSITY OF WASHINGTON
    Inventors: Pierre D. Mourad, Brandt Mohr, Michel Kliot, Robert C.A. Frederickson, R. Lee Thompson, Jason L. Seawall
  • Publication number: 20070016031
    Abstract: Systems and methods for noninvasive assessment of cardiac tissue properties and cardiac parameters using ultrasound techniques are disclosed. Determinations of myocardial tissue stiffness, tension, strain, strain rate, and the like, may be used to assess myocardial contractility, myocardial ischemia and infarction, ventricular filling and atrial pressures, and diastolic functions. Non-invasive systems in which acoustic techniques, such as ultrasound, are employed to acquire data relating to intrinsic tissue displacements are disclosed. Non-invasive systems in which ultrasound techniques are used to acoustically stimulate or palpate target cardiac tissue, or induce a response at a cardiac tissue site that relates to cardiac tissue properties and/or cardiac parameters are also disclosed.
    Type: Application
    Filed: March 31, 2006
    Publication date: January 18, 2007
    Applicants: ALLEZ PHYSIONIX LIMITED, UNIVERSITY OF WASHINGTON
    Inventors: Pierre Mourad, Michel Kliot, Rex Patterson, Alec Rooke
  • Publication number: 20060100530
    Abstract: Methods and systems for long term monitoring of one or more physiological parameters such as respiration, heart rate, body temperature, electrical heart activity, blood oxygenation, blood flow velocity, blood pressure, intracranial pressure, the presence of emboli in the blood stream and electrical brain activity are provided. Data is acquired non-invasively using ambulatory data acquisition techniques.
    Type: Application
    Filed: September 26, 2005
    Publication date: May 11, 2006
    Applicants: Allez PhysiOnix Limited, University of Washington
    Inventors: Michel Kliot, Robert Frederickson, Kamran Forghani, Pierre Mourad
  • Publication number: 20060079773
    Abstract: Systems and methods for assessing a physiological parameter of a target tissue wherein a pulse of focused ultrasound is applied to a target tissue site thereby inducing oscillation of the target tissue. By these systems and methods, a property of an acoustic signal emitted from the oscillating target tissue is measured and related to a physiological property of the tissue. Specific applications for systems and methods of the present invention include the assessment and monitoring of intracranial pressure (ICP), arterial blood pressure (ABP), CNS autoregulation status, vasospasm, stroke, local edema, infection and vasculitus, as well as diagnosis and monitoring of diseases and conditions that are characterized by physical changes in tissue properties.
    Type: Application
    Filed: February 4, 2005
    Publication date: April 13, 2006
    Applicants: ALLEZ PHYSIONIX LIMITED, UNIVERSITY OF WASHINGTON
    Inventors: Pierre Mourad, Michel Kliot, Robert Frederickson
  • Patent number: 7022077
    Abstract: Systems and methods for noninvasive assessment of cardiac tissue properties and cardiac parameters using ultrasound techniques are disclosed. Determinations of myocardial tissue stiffness, tension, strain, strain rate, and the like, may be used to assess myocardial contractility, myocardial ischemia and infarction, ventricular filling and atrial pressures, and diastolic functions. Non-invasive systems in which acoustic techniques, such as ultrasound, are employed to acquire data relating to intrinsic tissue displacements are disclosed. Non-invasive systems in which ultrasound techniques are used to acoustically stimulate or palpate target cardiac tissue, or induce a response at a cardiac tissue site that relates to cardiac tissue properties and/or cardiac parameters are also disclosed.
    Type: Grant
    Filed: July 1, 2003
    Date of Patent: April 4, 2006
    Assignees: Allez Physionix Ltd., University of Washington
    Inventors: Pierre D. Mourad, Michel Kliot, Rex Patterson, Alec Rooke
  • Patent number: 6875176
    Abstract: Systems and methods for assessment of tissue properties, noninvasively, by acquiring data relating to at least one aspect of intrinsic and/or induced tissue displacement, or associated biological responses, are provided. Data relating to tissue displacement and associated biological changes may be acquired by detecting acoustic properties of tissue using ultrasound interrogation pulses, preferably in a scatter or Doppler detection mode. Based on this data, tissue properties are assessed, characterized and monitored. Specific applications for systems and methods of the present invention include non-invasive assessment and monitoring of intracranial pressure (ICP), arterial blood pressure (ABP), CNS autoregulation status, vasospasm, stroke, local edema, infection and vasculitus, as well as diagnosis and monitoring of diseases and conditions that are characterized by physical changes in tissue properties.
    Type: Grant
    Filed: November 28, 2001
    Date of Patent: April 5, 2005
    Assignees: Aller Physionix Limited, University of Washington
    Inventors: Pierre D. Mourad, Michel Kliot, Ali Mesiwala, Rex Patterson, Jeffrey G. Jarvik
  • Publication number: 20050015009
    Abstract: Systems and methods for determining ICP based on parameters that can be measured using non-invasive or minimally invasive techniques are provided, wherein a non-linear relationship is used to determine ICP based on one or more variable inputs. The first variable input relates to one or more properties of a cranial blood vessel and/or blood flow, such as acoustic backscatter from an acoustic transducer having a focus trained on a cranial blood vessel, flow velocity in a cranial blood vessel, and the like. Additional variables, such as arterial blood pressure (ABP), may be used in combination with a first variable input relating to one or more properties of a cranial blood vessel, such as flow velocity of the middle cerebral artery (MCA) to derive ICP using a non-linear relationship.
    Type: Application
    Filed: June 3, 2004
    Publication date: January 20, 2005
    Applicants: ALLEZ PHYSIONIX , INC., UNIVERSITY OF WASHINGTON
    Inventors: Pierre Mourad, Brandt Mohr, Michel Kliot, Robert Frederickson, R. Thompson, Jason Seawall
  • Publication number: 20040059220
    Abstract: Systems and methods for noninvasive assessment of cardiac tissue properties and cardiac parameters using ultrasound techniques are disclosed. Determinations of myocardial tissue stiffness, tension, strain, strain rate, and the like, may be used to assess myocardial contractility, myocardial ischemia and infarction, ventricular filling and atrial pressures, and diastolic functions. Non-invasive systems in which acoustic techniques, such as ultrasound, are employed to acquire data relating to intrinsic tissue displacements are disclosed. Non-invasive systems in which ultrasound techniques are used to acoustically stimulate or palpate target cardiac tissue, or induce a response at a cardiac tissue site that relates to cardiac tissue properties and/or cardiac parameters are also disclosed.
    Type: Application
    Filed: July 1, 2003
    Publication date: March 25, 2004
    Applicants: ALLEZ PHYSIONIX LIMITED, UNIVERSITY OF WASHINGTON
    Inventors: Pierre D. Mourad, Michel Kliot, Rex Patterson, George Alec Rooke
  • Publication number: 20020095087
    Abstract: Systems and methods for assessment of tissue properties, noninvasively, by acquiring data relating to at least one aspect of intrinsic and/or induced tissue displacement, or associated biological responses, are provided. Data relating to tissue displacement and associated biological changes may be acquired by detecting acoustic properties of tissue using ultrasound interrogation pulses, preferably in a scatter or Doppler detection mode. Based on this data, tissue properties are assessed, characterized and monitored. Specific applications for systems and methods of the present invention include non-invasive assessment and monitoring of intracranial pressure (ICP), arterial blood pressure (ABP), CNS autoregulation status, vasospasm, stroke, local edema, infection and vasculitus, as well as diagnosis and monitoring of diseases and conditions that are characterized by physical changes in tissue properties.
    Type: Application
    Filed: November 28, 2001
    Publication date: July 18, 2002
    Inventors: Pierre D. Mourad, Michel Kliot, Ali Mesiwala, Rex Patterson, Jeffrey G. Jarvik
  • Publication number: 20020007190
    Abstract: Intralumenal material removal systems are provided. The intralumenal material removal system includes a cutter assembly positionable in the lumen of a mammalian subject and operably connected to system controls. One composite cutter assembly comprises a distal, fixed diameter cutter and a proximal, adjustable diameter cutter, the cutter assembly being axially advanceable by translating the drive shaft and rotatable by rotating the drive shaft. The adjustable cutting assembly is adjustable between a smaller diameter condition and a larger diameter condition by rotation of the drive shaft in opposite directions. The cutter may thus be introduced to and withdrawn from the material removal site in a retracted, smaller diameter condition that facilitates translation and navigation of the device through various lumens. The adjustable cutting assembly may be selectively expanded at the material removal site to facilitate cutting, removal and aspiration of the occlusive material.
    Type: Application
    Filed: April 4, 2001
    Publication date: January 17, 2002
    Inventors: Edward I. Wulfman, Thomas J. Clement, Craig E. Lawson, Michel Kliot, David C. Auth