Patents by Inventor Michel Lonchampt
Michel Lonchampt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5919801Abstract: New N-substituted cyclic amines of formula: ##STR1## wherein: X, R.sub.1, R.sub.2 and R are as defined in the description, their optical and geometric isomers and physiologically tolerable salts thereof. The compounds of the invention are powerful PDE4 inhibitors and can be used therapeutically.Type: GrantFiled: September 19, 1997Date of Patent: July 6, 1999Assignee: Adir et CompagnieInventors: Alain Dhainaut, Andre Tizot, Emmanuel Canet, Michel Lonchampt
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Patent number: 5889003Abstract: A compound of general formula (I): ##STR1## in which: R.sub.1 represents alkyl,X represents oxygen, --CHR'-- or --CR'.dbd.,R' is chosen from hydrogen and alkyl,R.sub.2 represents optionally substituted alkyl as is defined in the description, cycloalkyl or polycycloalkyl as are defined in the description,R.sub.3 represents hydrogen or hydroxyl,Alk represents alkylene, andY is as defined in the description,and medicinal products containing the same are useful as PDE IV inhibitors.Type: GrantFiled: September 26, 1997Date of Patent: March 30, 1999Assignee: Adir Et CompagnieInventors: Alain Dhainaut, Guy Lewin, Emmanuel Canet, Michel Lonchampt, Yves Rolland
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Patent number: 5877190Abstract: A compound of formula (I): ##STR1## wherein: R.sub.1 represents unsubstituted or substituted cycloalkyl, phenyl, naphthyl, heterocyclic, alkyl or alkenyl,A represents a bond, oxygen, sulphur, a group ##STR2## a group ##STR3## or a group ##STR4## wherein Rc represents hydrogen, alkyl or cycloalkyl, R.sub.2 represents halogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, cycloalkyl, formyl, carboxy, alkylcarbonyl, cycloalkylcarbonyl, alkoxycarbonyl, cycloalkyloxycarbonyl, optionally substituted carbamoyl, optionally substituted amino, formylamino, cyano, optionally substituted amidino, hydroxyaminomethyl, amide oxime, hydrazono, or a group selected from: ##STR5## wherein R.sub.21, R.sub.22 and R.sub.23 are as defined in the description, R.sub.Type: GrantFiled: October 3, 1997Date of Patent: March 2, 1999Assignee: Adir et CompagnieInventors: Alain Dhainaut, Guillaume Poissonnet, Emmanuel Canft, Michel Lonchampt
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Patent number: 5708016Abstract: A compound of formula (I): ##STR1## in which: R.sub.1 represents an indolyl, naphthyl, tetrahydronaphthyl, thienyl, phenyl, optionally substituted, or (C.sub.3 -C.sub.7)cycloalkyl group,n represents an integer such that 1.ltoreq.n.ltoreq.8,m represents an integer such that 1.ltoreq.m.ltoreq.4,R.sub.2 represents an unsubstituted or substituted benzyl group, an unsubstituted or substituted phenyl group or a linear or branched (C.sub.1 -C.sub.6)alkyl group, its enantiomers, diastereoisomers and epimers as well as its addition salts with a pharmaceutically acceptable acid or base, and medicinal products containing the same are useful as substance P antagonists.Type: GrantFiled: February 14, 1997Date of Patent: January 13, 1998Assignee: Adir et CompagnieInventors: Jean-Luc Fauchere, Nathalie Kucharczyk-Gentric, Emmanuel Canet, Michel Lonchampt
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Patent number: 5698567Abstract: The invention provides new compounds pertaining to the class of:aryl methoxy phenyl alkyl heterocyclic spiro compounds, enantiomers, diastereoisomers and physiologically-tolerable salts thereof.For example:8-{2-?3-quinol-2-yl methoxy)phenyl!ethyl}-3,8-diaza-1-oxa-2-oxo spiro?4,5!decane is described.Medicinal products containing the same are useful in the treatment of any pathology involving modifications of leukotriene metabolism.Type: GrantFiled: May 16, 1996Date of Patent: December 16, 1997Assignee: Adir Et CompagnieInventors: Claude Guillonneau, Yves Charton, Gilbert Regnier, Emmanuel Canet, Michel Lonchampt
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Patent number: 5565429Abstract: Compounds of formula (I): ##STR1## wherein: R.sub.1 represents an unsubstituted or substituted alkyl,R.sub.2 represents an unsubstituted or substituted alkyl,A represents, with the nitrogen and carbon atoms to which it is attached, a nitrogenous mono- or polycyclic structure, andB represent any one of the radicals a through j as defined in the description, and medicaments containing the same, are useful as human leucocyte elastase inhibitors.Type: GrantFiled: May 11, 1995Date of Patent: October 15, 1996Assignee: Adir et CompagnieInventors: Michel Vincent, Guillaume de Nanteuil, Georges Remond, Bernard Portevin, Yolande Herve, Emmanuel Canet, Michel Lonchampt
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Patent number: 4968705Abstract: New benzopyrrolidinone compounds, which can be used as medicaments and correspond to the formula ##STR1## in which: either: R.sub.1 and R.sub.2 together represent, with the bond of the etherocycle to which they are attached, an optionally substituted benzene nucleus and, simultaneously, R.sub.3 and R.sub.4 are hydrogen, (C.sub.1 -C.sub.4)alkyl or (C.sub.5 -C.sub.6)cycloalkyl;or:R.sub.1 is hydrogen, R.sub.4 is a single bond and R.sub.2 and R.sub.3 together represent, with the bond of the heterocycle to which they are bonded, an optionally substituted benzene nucleus; andA is a straight or branched hydrocarbon chain having from 2 to 6 carbon atoms that is optionally substituted by hydroxy;X is a single bond, oxygen or sulphur; andY is hydrogen, halogen or (C.sub.1 -C.sub.5)alkyl or alkoxy.These new compounds and the physiologically tolerable salts thereof can be used therapeutically, especially in the treatment of bronchospastic disorders and inflammations in the ENT area.Type: GrantFiled: August 10, 1989Date of Patent: November 6, 1990Assignee: Adir et CieInventors: Gilbert Regnier, Alain Dhainaut, Jacques Duhault, Michel Lonchampt
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Patent number: 4824836Abstract: Spiro (4,5) decane compounds of the formula: ##STR1## in which: X is methyl andY is hydrogen or R'--CO-- in which R' is C.sub.1 -C.sub.4 -alkyl or C.sub.1 -C.sub.4 -alkoxy, ##STR2## X and Y together represent ##STR3## in each of which A is hydrogen, methyl, carboxy, methoxycarbonyl or ethoxycarbonyl;R is C.sub.1 -C.sub.7 -alkyl optionally containing a double bond;Z is a C.sub.2 -C.sub.7 -polymethylene chain optionally carrying an OH group;R.sub.1 is hydrogen or methyl; andR.sub.2 is hydrogen, R'--CO-- or benzyloxycarbonyl;and physiologically tolerable acid addition salts thereof.These compounds may be used therapeutically especially in the treatment of asthma, allergic phenomena and bronchopathies.Type: GrantFiled: May 20, 1988Date of Patent: April 25, 1989Assignee: Adir et CompagnieInventors: Gilbert Regnier, Claude Guillonneau, Jacques Duhault, Michel Lonchampt