Abstract: A device for loading and unloading a machine tool for machining gears, in particular a hard fine machining machine, with a workpiece includes: a base, a carrier arranged on the base and which is rotatable with respect to the base about a first axis of rotation, a gripping device arranged on the carrier for gripping and releasing the workpiece, wherein the gripping device has at least two gripper arms which are each pivotable independently of one another about a second axis of rotation, and the gripper arms are pivotable relative to one another about the second axis of rotation in such a way that the gripper arms can assume relative to one another a gripping position for gripping the workpiece and a release position for releasing the workpiece, and the gripper arms are pivotable about the second axis of rotation synchronously with one another at least in the gripping position.

Abstract: The present invention relates to macrocyclic compounds and compositions containing said compounds acting as kinase inhibitors, in particular as inhibitors of BTK (Bruton's Tyrosine Kinase). Moreover, the present invention provides processes for the preparation of the disclosed compounds, as well as methods of using them, for instance as a medicament, in particular for the treatment of Bruton's Tyrosine Kinase (BTK) mediated disorders, such as cancer.

Abstract: A device for machining a gear using a rotating machining tool. The device has a motor spindle having a drive motor and motor spindle shaft drivable by the drive motor for driving the machining tool. The device has an attachment structure for releasably attaching the device to a work spindle of a tool head. The attachment structure is configured so the tool axis is parallel to the work spindle axis when the device is attached to the work spindle. A device is further disclosed to connect a machining tool to a counter bearing in a simple manner. For this purpose, the counter bearing has a hollow shaft. A mandrel having first and second clamping regions are arranged at positions along the longitudinal axis of the mandrel. The mandrel is inserted through the hollow shaft along the tool axis into a longitudinal bore of the machining tool.

Abstract: A microstructure for use in a micro electro-mechanical device comprises a substrate having a top surface and a rear surface and a thin-film structure arranged at the top surface of the substrate. The thin-film structure comprises a raised portion spaced from the substrate, a lower portion of the thin-film structure, which is in mechanical contact with the substrate, at least one protruding portion, the protruding portion being hollow and having at least one sidewall and a bottom part and the protruding portion mechanically connecting the raised portion to the substrate via the bottom part, and at least one further sidewall of the thin-film structure at a distance to the at least one protruding portion, wherein the further sidewall mechanically connects the lower portion with the raised portion of the thin-film structure.

Abstract: A tool head for a machine tool, in particular for a gear cutting machine, has a first and a second spindle unit each having at least one spindle bearing and a spindle shaft which is rotatably mounted in the respective spindle bearing about a tool spindle axis. The respective spindle bearing can support both radial and axial forces. The spindle units are arranged coaxially to each other, and a tool is received axially between the spindle shafts. A controlled clamping device connects the spindle bearings together. A control device activates the clamping device during a machining operation and deactivates it during machining pauses. Alternatively or additionally, the tool head has an axial force element that generates an axial preload force between the spindle bearings.

Abstract: A tool changer is used for changing tools in a machine tool. The tool changer has a support structure on which a lifting carriage is guided along a vertical lifting direction. A pivot arm is pivotably mounted to the lifting carriage about a vertical pivot axis. A plurality of tool holders arranged vertically one above the other form a tool magazine. A tool gripper is attached to the pivot arm. The tool gripper grips a tool. The tool is subsequently moved between one of the tool holders and the tool spindle of the machine tool by a combined lifting and pivoting movement of the pivot arm. Optionally, an auxiliary arm pivotably attached to the pivot arm can be used to change a workpiece clamping means of the machine tool.

Abstract: A tool head for a gear cutting machine includes a first spindle unit having a first spindle shaft and a second spindle unit having a second spindle shaft. A tool is axially receivable between the first spindle shaft and the second spindle shaft. A balancing device is associated with each spindle unit. The balancing device radially surrounds the respective spindle shaft and is axially arranged between a tool-side spindle bearing of the corresponding spindle unit and the tool-side end of the corresponding spindle shaft. The tool is axially clamped between the two spindle shafts by a pull rod and a clamping element.

Abstract: A hub flange has a fixed flange configured to receive a tool body. A flange socket is formed on the fixed flange for connection to a spindle shaft. A counterflange is detachably connected to the fixed flange. The fixed flange and the counterflange are connected to each other via a conical connection, wherein the conical connection is arranged coaxially to the tool axis and is formed by an inner cone and an outer cone received therein.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for generating control policies for controlling agents in an environment. One of the methods includes, at each of a plurality of iterations: obtaining a current joint control policy for a plurality of agents, the current joint control policy specifying a respective current control policy for each agent; and updating the current joint control policy, comprising, for each agent: generating a respective reward estimate for each of a plurality of alternate control policies that is an estimate of a reward received by the agent if the agent is controlled using the alternate control policy while the other agents are controlled using the respective current control policies; computing a best response for the agent from the respective reward estimates; and updating the respective current control policy for the agent using the best response for the agent.

Abstract: The invention relates to a method for measuring a tool (1) for roll machining toothed workpieces, wherein a virtual contact points is calculator on a rounded virtual blade of a virtual tool. The relative orientation between the tool axis (B) and the measuring device (11) as well as a translational relative position between the tool and the measuring device are then calculated and adjusted on the basis of the calculated virtual contact point. The measurement is taken on the real blade in the adjusted relative orientation and relative position, and the measurement can be taken in particular using a cylindrical scanning means in the form of a laser beam, wherein the cylindrical scanning means tangentially contacts the virtual blade in the virtual contact point.

Abstract: A machine tool (1) for processing gears comprises a workpiece spindle (16) for driving a workpiece (18) to rotate about a workpiece axis (C1), and a tool spindle (11) for driving a tool (12) to rotate about a tool axis (B). An axial slide (7) is used to change a relative axial feed position between the tool spindle and the workpiece spindle with respect to the workpiece axis. The axial slide is guided along an axial guide direction (Z?) which is inclined with respect to the workpiece axis by an inclination angle (?), the inclination angle (?) being between 0.1° and 30°.

Abstract: A membrane structure comprises a substrate having a main surface and a rear surface. A plurality of pillars are arranged on the main surface of the substrate and have a support area facing away from the main surface of the substrate. A thin-film structure is arranged above the main surface of the substrate and the pillars, wherein the thin-film structure comprises a plurality of raised portions that are spaced further from the substrate than at least one lower portion of the thin film structure. The raised portions each comprise at least one protruding portion, the protruding portions being hollow and having a bottom part and a sidewall and the protruding portions extending towards the substrate. The bottom part of each protruding portion is mechanically connected to the support area of one of the pillars, respectively. A back-volume is formed by the volume between the main surface of the substrate and the thin-film structure.

Abstract: A microstructure for use in a micro electro-mechanical device comprises a substrate having a top surface and a rear surface and a thin-film structure arranged at the top surface of the substrate. The thin-film structure comprises a raised portion spaced from the substrate, a lower portion of the thin-film structure, which is in mechanical contact with the substrate, at least one protruding portion, the protruding portion being hollow and having at least one sidewall and a bottom part and the protruding portion mechanically connecting the raised portion to the substrate via the bottom part, and at least one further sidewall of the thin-film structure at a distance to the at least one protruding portion, wherein the further sidewall mechanically connects the lower portion with the raised portion of the thin-film structure.

Abstract: A machine tool is designed for the machining of rotary parts with groove-shaped profiles, in particular gears, by a generating method. On the one hand, a Y slide (200) is arranged on a machine bed (100), the Y slide being displaceable along a Y direction and carrying a workpiece spindle (210). The workpiece spindle drives a workpiece (220) to rotate about a workpiece axis (C). On the other hand, a Z slide (300) is arranged on the machine bed. The Z slide is arranged along a Z direction running parallel to a center plane (E1) spanned by the Y direction and the workpiece axis. An X slide (310) is arranged on the Z slide and can be displaced along an X direction relative to the Z slide (300). The X direction is perpendicular to the center plane. A tool spindle (320) is arranged on the X slide, which drives a tool to rotate about a tool axis. The tool spindle can be swiveled relative to the X slide in a swivel plane (E2), which runs parallel to the center plane, about a swivel axis (A).

Abstract: The invention relates to a method for measuring a tool (1) for roll machining toothed workpieces, wherein a virtual contact points is calculator on a rounded virtual blade of a virtual tool. The relative orientation between the tool axis (B) and the measuring device (11) as well as a translational relative position between the tool and the measuring device are then calculated and adjusted on the basis of the calculated virtual contact point. The measurement is taken on the real blade in the adjusted relative orientation and relative position, and the measurement can be taken in particular using a cylindrical scanning means in the form of a laser beam, wherein the cylindrical scanning means tangentially contacts the virtual blade in the virtual contact point.

Abstract: A mechanical transducer for the detection of acoustic and/or seismic signals is indicated, comprising a continuous or discrete coupled mass-spring network with varying masses and/or spring constants. The mass-spring network is adapted to transform a comparatively small-dimensioned motion parameter of a first mass element into a comparatively large-dimensioned motion parameter of a further mass element. Between the first mass element and the further mass element, the mass-spring network comprises one or more intermediate mass elements, which are coupled to the first mass element and the further mass element by means of spring elements.

Abstract: A fluid bed granulation process for manufacturing non-hygroscopic, stable granulates containing a water-soluble salt of S-adenosylmethionine is described. Said process comprises: a) the simultaneous, sequential or alternate dispersion of at least a solution of a water-soluble salt of SAMe (A) and of a solution of a coating agent (B), on a fluid bed granulation carrier (C) and b) the fluid bed granulation of the mixture. Granulates obtainable by said process and solid oral pharmaceutical forms obtainable by said granulates are disclosed.

Abstract: A fluid bed granulation process for manufacturing non-hygroscopic, stable granulates containing a water-soluble salt of S-adenosylmethionine is described. Said process comprises: a) the simultaneous, sequential or alternate dispersion of at least a solution of a water-soluble salt of SAMe (A) and of a solution of a coating agent (B), on a fluid bed granulation carrier (C) and b) the fluid bed granulation of the mixture. Granulates obtainable by said process and solid oral pharmaceutical forms obtainable by said granulates are disclosed.