Abstract: A method of angiographic evaluation of a flow diverter in a region of interest having abnormal flow in a vessel of interest, the method using digital division angiogram images at a first segment at or near a proximal end of the region of interest and at a second segment at or near a distal end of the region of interest, and observing differences in flow seen at said first and second segments.

Abstract: Multi-modal tumor imaging of neuroblastoma is essential for tumor staging, response evaluation and detection of relapsed diseased. The present invention provides a norepinephine analogue with a near-infrared (near-IR) dye, W765-BG, that efficiently and stably detects neuroblastoma in vivo using near-IR optical imaging. Confocal microscopy and optical imaging of neuroblastoma xenografts shows cell specific uptake and reveals exceptional tumor retention with a high tumor-to-tissue ratio up to 7 days after injection of W765-BG.

Abstract: The present invention provides nonradioactive NIR optical imaging agents based up on the structure of retinoid acid derivatives. The nonradioactive NIR optical imaging agent has been evaluated at the cellular level by confocal microscopy, and in vivo in a whole animal using a various xenograft models. The specific uptake of this agent in human cancer cells and multiple xenograft models demonstrate that nonradioactive near infrared dye labeled retinoid metabolites and/or analogs are useful for early stage cancer studies and diagnoses. Also, the present invention provides that nonradioactive near infrared dye labeled retinoid metabolites and/or analogs are useful for visualization of drug redistribution within the body which is useful in determining the optimal biological dose. Ultimately, the visualization data can be used as an analytical tool to reduce any systemic toxicity.

Abstract: A catheter for providing an embolic material at a desired location comprises a flexible tubular member having a proximal end and a distal end, the tubular member including at least one ring of expansible material affixed to its outer surface less than 25 mm from the distal end. The ring preferably comprises a material that expands in volume when in contact with a liquid, such as a hydrogel or hydrogel foam, or in response to an application of heat. The ring is fully expanded after between 10 and 30 minutes of contact with a liquid. The catheter may also include further including a plurality of radioopaque markers spaced along the tubular member at predetermined intervals.

Abstract: A method of creating a surface model of an intracranial aneurysm in an artery having a lumen, the aneurysm having a neck and a dome and the virtual reconstruction of the parent artery across the lateral extension of the aneurysm neck. The method includes the steps of: determining a center and radius of the artery over the lateral extension of the aneurysm; determining the boundary points that mark the boundary between the aneurysm neck and the artery; determining the angle of the aneurysm neck with respect to the artery, for various cross sections of the neck; determining the length of the neck; determining the height of the dome; estimating the area of the neck; and creating the surface model of the intracranial aneurysm in the artery, using the results from the previous steps.

Abstract: A catheter for providing an embolic material at a desired location comprises a flexible tubular member having a proximal end and a distal end, the tubular member including at least one ring of expansible material affixed to its outer surface less than 25 mm from the distal end. The ring preferably comprises a material that expands in volume when in contact with a liquid, such as a hydrogel or hydrogel foam, or in response to an application of heat. The ring is fully expanded after between 10 and 30 minutes of contact with a liquid. The catheter may also include further including a plurality of radioopaque markers spaced along the tubular member at predetermined intervals.