Patents by Inventor Michel Miesch

Michel Miesch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DERIVATIVES OF ALLOPREGNANOLONE AND OF EPIALLOPREGNANOLONE AND USES THEREOF FOR TREATING A NEUROPATHOLOGICAL CONDITION
    Publication number: 20190002492
    Abstract: The present invention relates to novel neurosteroids, especially derivatives of allopregnanolone and of epiallopregnanolone of formula (I) and the uses thereof as medicament for the treatment of neuropathologies, in particular neuropathies induced by the chemotherapy of a cancer. These molecules according to the invention have both preventative and curative effects. The neurosteroids according to the invention may also be of use in the treatment of neurodegenerative disorders, in particular for preventing neuronal cell death. They may thus be used as neuroprotectants and/or as an agent that stimulates neuronal proliferation.
    Type: Application
    Filed: May 8, 2018
    Publication date: January 3, 2019
    Applicants: UNIVERSITE DE STRASBOURG, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS
    Inventors: Ayikoe Guy Mensah-Nyagan, Laurence Meyer, Christine Patte-Mensah, Omar Taleb, Michel Miesch, Philippe Geoffroy, Blandine Ressault
  • DERIVATIVES OF ALLOPREGNANOLONE AND OF EPIALLOPREGNANOLONE AND USES THEREOF FOR TREATING A NEUROPATHOLOGICAL CONDITION
    Publication number: 20140058079
    Abstract: The présent invention relates to novel neurosteroids, especially derivatives of allopregnanolone and of epiallopregnanolone of formula (I) and the uses thereof as médicament for the treatment of neuropathologies, in particular neuropathies induced by the chemotherapy of a cancer. Thèse molécules according to the invention have both preventative and curative effects. The neurosteroids according to the invention may also be of use in the treatment of neurodegenerative disorders, in particular for preventing neuronal cell death. They may thus be used as neuroprotectants and/or as an agent that stimulâtes neuronal prolifération.
    Type: Application
    Filed: March 23, 2012
    Publication date: February 27, 2014
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS, UNIVERSITE DE STRASBOURG
    Inventors: Ayikoe Guy Mensah-Nyagan, Laurence Meyer, Christine Patte-Mensah, Omar Taleb, Michel Miesch, Philippe Geoffroy, Blandine Ressault
  • Process for the preparation of cyclopropene intermediates
    Patent number: 4410721
    Abstract: A novel cyclopropene-carboxylate of the formula ##STR1## wherein R is alkyl of 1 to 6 carbon atoms and their preparation and a process using the compounds of formula I to obtain cis compounds of the formula ##STR2##
    Type: Grant
    Filed: July 16, 1981
    Date of Patent: October 18, 1983
    Assignee: Roussel Uclaf
    Inventors: Michel Franck-Neumann, Michel Miesch
  • Alkyl 3,3-dimethyl-2-(2-hydroxy-2-methyl-propyl)-1-cyclopropene-1-carboxylates
    Patent number: 4299973
    Abstract: A novel cyclopropene-carboxylate of the formula ##STR1## wherein R is alkyl of 1 to 6 carbon atoms and their preparation and a process using the compounds of formula I to obtain cis compounds of the formula ##STR2##
    Type: Grant
    Filed: August 28, 1980
    Date of Patent: November 10, 1981
    Assignee: Roussel Uclaf
    Inventors: Michel Franck-Neumann, Michel Miesch
  • Process of preparation of alkyl esters of dl cis chrysanthemic acid
    Patent number: 4233129
    Abstract: A process for the production of an alkyl ester of dl cis chrysanthemic acid having the formula ##STR1## wherein R is an alkyl having from 1 to 6 carbon atoms, involving preparing a lithiated derivative of 2-methyl-pent-2-en-4-yne, reacting the same with an alkyl chloroformate, optionally reducing the acetylenic bond to an ethylenic bond, reacting the alkyl ester with diazo-2-propane, irradiating or heating the resultant pyrazole carboxylate and, if not previously reduced, subjecting the resultant cyclopropane carboxylate to the action of a reducing agent.
    Type: Grant
    Filed: July 20, 1979
    Date of Patent: November 11, 1980
    Assignee: Roussel Uclaf
    Inventors: Michel Franck-Neumann, Christiane Dietrich-Buchecker, Michel Miesch