Abstract: Techniques are described for contouring of a region of interest based on imaging parameters of spatial imaging data and guided by user input of locations in the spatial imaging data, which may be used for segmentation or radiation treatment planning. An approach is described of combining a new paint brush tool with an edge-detection algorithm to correct for both the jagged contours and the painting routine not being executed often enough. By using an edge-detection algorithm, the user does not need to focus as much attention on moving the mouse accurately because the system will find the true organ boundary (e.g., using the image gradient) automatically, which may also lead to more time savings.

Abstract: The invention relates to methods of generating hepatic cells by overexpressing combinations of transcription factors, in particular for use in cellular reprogramming methods.

Abstract: The present disclosure relates to a method for use in adaptive radiotherapy and a treatment planning device. The method may comprise accessing a first medical image and a second medical image that represent a region of interest of a patient at different times. Each medical image is segmented into a target region and at least one non-target region. The method may further comprise accessing a deformation vector field including a plurality of vectors, wherein each vector defines a geometric transformation to map a respective voxel in the first medical image to a corresponding voxel in the second medical image.

Abstract: The invention relates to methods of generating hepatic cells by overexpressing combinations of transcription factors, in particular for use in cellular reprogramming methods.

Abstract: Turbomachine modules, for example for an aircraft, include a turbine nozzle having several sectors (S), each sector having guide vanes extending between inner and outer platform elements, at least one of the platform elements of each sector carrying, on the one hand, at least one sealing blade configured to ensure fluid sealing between the platform element and the adjacent structural element, and, on the other hand, a device configured to hold the at least one sealing blade in a sealing position. The device includes a leaf spring having a middle portion fixed to the platform element, and opposite end portions which are supported on the sealing blade carried by the platform element.

Abstract: The invention relates to methods of generating hepatic cells by overexpressing combinations of transcription factors, in particular for use in cellular reprogramming methods.

Abstract: Turbomachine modules, for example for an aircraft, include a turbine nozzle having several sectors (S), each sector having guide vanes extending between inner and outer platform elements, at least one of the platform elements of each sector carrying, on the one hand, at least one sealing blade configured to ensure fluid sealing between the platform element and the adjacent structural element, and, on the other hand, a device configured to hold the at least one sealing blade in a sealing position. The device includes a leaf spring having a middle portion fixed to the platform element, and opposite end portions which are supported on the sealing blade carried by the platform element.

Abstract: Radiation treatment planning and administration can include a Monte Carlo computer simulation tool to simulate photo-generated electrons in tissue. In the simulation, electrons that have left tissue voxels and entered air voxels can be evaluated to identify electrons that are circling along a spiraling trajectory in the air voxels. After at least one full spiraling circumference or other specified distance has been traversed using a detailed electron transport model, a simpler linear ballistic motion model can be instituted. This speeds simulation while accurately accounting for spiraling electrons that re-enter tissue voxels.

Abstract: The present disclosure relates to a method for use in adaptive radiotherapy and a treatment planning device. The method may comprise accessing a first medical image and a second medical image that represent a region of interest of a patient at different times. Each medical image is segmented into a target region and at least one non-target region. The method may further comprise accessing a deformation vector field including a plurality of vectors, wherein each vector defines a geometric transformation to map a respective voxel in the first medical image to a corresponding voxel in the second medical image.

Abstract: The present disclosure relates to a method for use in adaptive radiotherapy and a treatment planning device. The method may comprise accessing a first medical image and a second medical image that represent a region of interest of a patient at different times. Each medical image is segmented into a target region and at least one non-target region. The method may further comprise accessing a deformation vector field including a plurality of vectors, wherein each vector defines a geometric transformation to map a respective voxel in the first medical image to a corresponding voxel in the second medical image.

Abstract: A magnetic resonance transmit and/or receive antenna system configured for being used in combination with a magnetic resonance radiotherapy system. The antenna system can include at least one antenna for transmitting and/or receiving radio frequency signals and a cover enclosing the antenna components. The antenna can include antenna components and the cover can include a spatially varying thickness and/or density towards an outer edge of the surface and/or next to an antenna component as to make the change in radiation attenuation between the enclosing cover compared to the antenna component and/or air more gradual.

Abstract: Radiation treatment planning and administration can include a Monte Carlo computer simulation tool to simulate photo-generated electrons in tissue. In the simulation, electrons that have left tissue voxels and entered air voxels can be evaluated to identify electrons that are circling along a spiraling trajectory in the air voxels. After at least one full spiraling circumference or other specified distance has been traversed using a detailed electron transport model, a simpler linear ballistic motion model can be instituted. This speeds simulation while accurately accounting for spiraling electrons that re-enter tissue voxels.

Abstract: An image-guided therapy delivery system includes a therapy generator configured to generate a therapy beam directed to a time-varying therapy locus within a therapy recipient, an imaging input configured to receive imaging information about a time-varying target locus within the therapy recipient, and a therapy controller. The therapy generator includes a therapy output configured to direct the therapy beam according to a therapy protocol. The therapy controller is configured to automatically generate a predicted target locus using information indicative of an earlier target locus extracted from the imaging information, a cyclic motion model, and a specified latency, and automatically generate an updated therapy protocol to align the time-varying therapy locus with the predicted target locus.

Abstract: An adaptive therapy delivery system can receive imaging information including a volumetric image comprising a target such as a tumor or one or more other structures, and can receive imaging information corresponding to one or more imaging slices comprising different portions of the target, such as imaging slices acquired at different times after acquisition of the volumetric image. The system can spatially register information from an earlier-acquired image with a portion of the target included in a later-acquired one of the imaging slices. The system can then determine an updated location of the target indicated by the spatially-registered information. Using the updated location, the system can generate an updated therapy protocol to control delivery of a therapy beam.

Abstract: The present disclosure relates to a method for use in adaptive radiotherapy and a treatment planning device. The method may comprise accessing a first medical image and a second medical image that represent a region of interest of a patient at different times. Each medical image is segmented into a target region and at least one non-target region. The method may further comprise accessing a deformation vector field including a plurality of vectors, wherein each vector defines a geometric transformation to map a respective voxel in the first medical image to a corresponding voxel in the second medical image.

Abstract: An adaptive therapy delivery system can receive imaging information including a volumetric image comprising a target such as a tumor or one or more other structures, and can receive imaging information corresponding to one or more imaging slices comprising different portions of the target, such as imaging slices acquired at different times after acquisition of the volumetric image. The system can spatially register information from an earlier-acquired image with a portion of the target included in a later-acquired one of the imaging slices. The system can then determine an updated location of the target indicated by the spatially-registered information. Using the updated location, the system can generate an updated therapy protocol to control delivery of a therapy beam.

Abstract: An adaptive therapy delivery system can receive imaging information including a volumetric image comprising a target such as a tumor or one or more other structures, and can receive imaging information corresponding to one or more imaging slices comprising different portions of the target, such as imaging slices acquired at different times after acquisition of the volumetric image. The system can spatially register information from an earlier-acquired image with a portion of the target included in a later-acquired one of the imaging slices. The system can then determine an updated location of the target indicated by the spatially-registered information. Using the updated location, the system can generate an updated therapy protocol to control delivery of a therapy beam.

Abstract: Systems and methods for pre-aligning print head(s) to alignment adapter(s) to increase print resolution of printed matter, and to reduce offline time of a printing system due to print head alignment, include the use of an alignment adapter to which a print head is pre-aligned and which includes precision alignment features which precisely engage cooperating precision alignment features on the print head carriage mounting plate of the print head carriage. Print head(s) can be pre-aligned and fine-tuned to alignment adapter(s) even while the printing system is still in print production. Pre-aligned print head/alignment adapter assemblies can then be quickly mounted on the print head carriage using the cooperating precision alignment features of the adapter and print head carriage mounting plate. Duplicate sets of print head mounting sockets can include print heads aligned at different relative offsets (e.g., half a pixel) to increase the print resolution.

Abstract: A magnetic resonance transmit and/or receive antenna system configured for being used in combination with a magnetic resonance radiotherapy system. The antenna system can include at least one antenna for transmitting and/or receiving radio frequency signals and a cover enclosing the antenna components. The antenna can include antenna components and the cover can include a spatially varying thickness and/or density towards an outer edge of the surface and/or next to an antenna component as to make the change in radiation attenuation between the enclosing cover compared to the antenna component and/or air more gradual.

Abstract: An image-guided therapy delivery system includes a therapy generator configured to generate a therapy beam directed to a time-varying therapy locus within a therapy recipient, an imaging input configured to receive imaging information about a time-varying target locus within the therapy recipient, and a therapy controller. The therapy generator includes a therapy output configured to direct the therapy beam according to a therapy protocol. The therapy controller is configured to automatically generate a predicted target locus using information indicative of an earlier target locus extracted from the imaging information, a cyclic motion model, and a specified latency, and automatically generate an updated therapy protocol to align the time-varying therapy locus with the predicted target locus.