Patents by Inventor Michel Paques
Michel Paques has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10617658Abstract: The present invention relates to the use of hydroxycarbamide (HC) for reducing and/or delaying the extension of capillary nonperfusion, a cause of irreparable visual impairment in patients suffering from central retinal vein occlusion (CRVO). This is the first systemic treatment which makes it possible to reduce retinal ischemic complications in patients in whom (CRVO) has been recently diagnosed and is consequently in a rapidly progressive phase. Given the low toxicity of HC evaluated on a large scale in children and adults in the context of other diseases for decades, the results of the present study open up a new therapeutic approach in the treatment of CRVO.Type: GrantFiled: August 8, 2016Date of Patent: April 14, 2020Assignees: CENTRE HOSPITALIER NATIONAL D'OPHTALMOLOGIE QUINZE-VINGTS, INSTITUT NATIONAL DE LA SANTE DE LA RECHERCHE MEDICAL (INSERM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), IMAGINE INSTITUT DES MALADIES GENETIQUES NECKER ENFANTS MALADES, ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS, UNIVERSITE PARIS DESCARTESInventors: Yves Colin, Jean-Francois Girmens, Olivier Hermine, Emmanuel Heron, Michel Paques
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Publication number: 20180221313Abstract: The present invention relates to the use of hydroxycarbamide (HC) for reducing and/or delaying the extension of capillary nonperfusion, a cause of irreparable visual impairment in patients suffering from central retinal vein occlusion (CRVO). This is the first systemic treatment which makes it possible to reduce retinal ischemic complications in patients in whom (CRVO) has been recently diagnosed and is consequently in a rapidly progressive phase. Given the low toxicity of HC evaluated on a large scale in children and adults in the context of other diseases for decades, the results of the present study open up a new therapeutic approach in the treatment of CRVO.Type: ApplicationFiled: August 8, 2016Publication date: August 9, 2018Applicant: Centre National De La Recherche Scientifique (CNRS)Inventors: Yves COLIN, Jean-Francois GIRMENS, Olivier HERMINE, Emmanuel HERON, Michel PAQUES
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Patent number: 9308125Abstract: The present technology relates to an apparatus for intraocular injection comprising a plate adapted for being brought into contact with an eye and a guide operable to guide a needle into the interior of an eye, characterized in that it comprises means for displacing a superficial layer (1) of the eye over an underlying layer (2) of the eye as the plate is brought into contact with the eye before the needle is guided into the interior of the eye.Type: GrantFiled: January 9, 2008Date of Patent: April 12, 2016Assignees: FOVEA PHARMACEUTICALS, FONDATION OPHTALMOLOGIQUEADOLPHE DE ROTHSCHILDInventors: Michel Paques, Pierre Roy
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Patent number: 8808242Abstract: The invention relates to an apparatus for injection into an eye comprising of a means for displacing a conjunctival layer of the eye over an underlying scleral layer of the eye so as to form a fold in the conjunctival layer, and means for guiding a needle through the conjunctival layer once the fold has been formed.Type: GrantFiled: November 2, 2011Date of Patent: August 19, 2014Assignee: Fovea PharmaceuticalsInventors: Michel Paques, Pierre Roy
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Publication number: 20140073916Abstract: The invention relates to a device for assisting in detecting anatomical features of at least a portion of a tissue, in particular a retinal tissue, the device comprising means for acquiring images of said portion using optical coherence tomography (OCT), which are taken at separate angles of incidence, and detection means for detecting, in a single area of the portion studied, at least one pattern having at least one feature that varies from one image to another, the pattern being attributable to the presence of anatomical features. The invention likewise relates to a method for assisting in detecting anatomical features of at least a portion of a tissue.Type: ApplicationFiled: April 10, 2012Publication date: March 13, 2014Applicant: UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)Inventors: Michel Paques, Sarah Mrejen
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Publication number: 20130211335Abstract: The invention relates to an apparatus for injection into an eye comprising of a means for displacing a conjunctival layer of the eye over an underlying scleral layer of the eye so as to form a fold in the conjunctival layer, and means for guiding a needle through the conjunctival layer once the fold has been formed.Type: ApplicationFiled: November 2, 2011Publication date: August 15, 2013Applicant: FOVEA PharmaceuticalsInventors: Michel Paques, Pierre Roy
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Patent number: 8460242Abstract: The application relates to an apparatus for intraocular injection comprising a plate adapted for being brought into contact with an eye and guiding means for guiding a needle into the interior of an eye, characterized in that the plate comprises a cut-out having an edge adapted to be positioned along the limbus delimiting the cornea and the sclera of the eye, so as to adjust the position of the guiding means with respect to the limbus.Type: GrantFiled: January 9, 2008Date of Patent: June 11, 2013Assignees: Fovea Pharmaceuticals, Foundation Ophtalmologiqueadolphe de RothschildInventors: Michel Paques, Pierre Roy
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Publication number: 20100030150Abstract: The application relates to an apparatus for intraocular injection comprising a plate adapted for being brought into contact with an eye and guiding means for guiding a needle into the interior of an eye, characterized in that the plate comprises a cut-out having an edge adapted to be positioned along the limbus delimiting the cornea and the sclera of the eye, so as to adjust the position of the guiding means with respect to the limbus.Type: ApplicationFiled: January 9, 2008Publication date: February 4, 2010Applicants: FOVEA PHARMACEUTICALS, FONDATION OPHTALMOLOGIQUE ADOLPHE DE ROTHSCHILDInventors: Michel Paques, Pierre Roy
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Publication number: 20100010452Abstract: The present technology relates to an apparatus for intraocular injection comprising a plate adapted for being brought into contact with an eye and a guide operable to guide a needle into the interior of an eye, characterized in that it comprises means for displacing a superficial layer (1) of the eye over an underlying layer (2) of the eye as the plate is brought into contact with the eye before the needle is guided into the interior of the eye.Type: ApplicationFiled: January 9, 2008Publication date: January 14, 2010Applicants: FOVEA PHARMACEUTICALS, FOUDATION OPHTALMOLOGIQUE ADOLPHE DE ROTHSCHILDInventors: Michel Paques, Pierre Roy
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Publication number: 20090292021Abstract: Pharmaceutical compositions including, as the active ingredients, a combination of vigabatrin and of at least one substance having anti-ischemic effect, are disclosed.Type: ApplicationFiled: July 31, 2007Publication date: November 26, 2009Applicant: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECInventors: Serge Picaud, Agnes Duboc, Michel Paques, Jose Sahel, Manuel Simonutti
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Publication number: 20050118945Abstract: Device for transmitting energy in a system for cabled telecommunication. The system comprises first and second pairs of telecommunication wires (TP). The device comprises a central module or base station arranged to be connected to an electrical energy source and for the first and second pairs of wires to be connected thereto. A satellite comprises a first satellite converter. The first satellite converter comprises a first input arranged for the first pair of wires to be connected thereto and a second input arranged for the second pair of wires to be connected thereto.Type: ApplicationFiled: November 18, 2004Publication date: June 2, 2005Inventors: Fabrice Frebel, Michel Paque, Paul Bleus
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Publication number: 20030171722Abstract: A microsurgical injection instrument particularly useful by a physician for injecting a liquid substance or a suspension into a blood vessel in the retina of a subject's eye, includes a handpiece carrying a hollow needle at its distal end, for penetrating the blood vessel. The longitudinal axis of the distal end of the handpiece and of the needle is at an angle of from 90°-180°, preferably about 145°, to the longitudinal axis of the proximal end of the handpiece to facilitate orienting the needle substantially tangentially to the plane of the subject's retina coaxially to a blood vessel for penetrating the blood vessel. The instrument may also be used to treat an occluded blood vessel by moving a flexible tube through the hollow needle, after the needle has penetrated the blood vessel, to enter and catheterize the blood vessel.Type: ApplicationFiled: February 27, 2003Publication date: September 11, 2003Inventors: Michel Paques, Nathanael Benhamou
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Publication number: 20020087128Abstract: A microsurgical injection instrument particularly useful by a physician for injecting a liquid substance or a suspension into a blood vessel in the retina of a subject's eye, includes a handpiece carrying a hollow needle at its distal end, for penetrating the blood vessel. The longitudinal axis of the distal end of the handpiece and of the needle is at an angle of from 120° to 80°, preferably about 145°, to the longitudinal axis of the proximal end of the handpiece to facilitate orienting the needle substantially tangentially to the plane of the subject's retina for penetrating the blood vessel. The instrument may also be used to treat an occluded blood vessel by moving a flexible tube through the hollow needle, after the needle has penetrated the blood vessel, to enter and catheterize the blood vessel.Type: ApplicationFiled: January 4, 2001Publication date: July 4, 2002Applicant: MPNB Ltd.Inventors: Michel Paques, Nathanael Benhamou