Patents by Inventor Michel Paques

Michel Paques has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10617658
    Abstract: The present invention relates to the use of hydroxycarbamide (HC) for reducing and/or delaying the extension of capillary nonperfusion, a cause of irreparable visual impairment in patients suffering from central retinal vein occlusion (CRVO). This is the first systemic treatment which makes it possible to reduce retinal ischemic complications in patients in whom (CRVO) has been recently diagnosed and is consequently in a rapidly progressive phase. Given the low toxicity of HC evaluated on a large scale in children and adults in the context of other diseases for decades, the results of the present study open up a new therapeutic approach in the treatment of CRVO.
    Type: Grant
    Filed: August 8, 2016
    Date of Patent: April 14, 2020
    Assignees: CENTRE HOSPITALIER NATIONAL D'OPHTALMOLOGIE QUINZE-VINGTS, INSTITUT NATIONAL DE LA SANTE DE LA RECHERCHE MEDICAL (INSERM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), IMAGINE INSTITUT DES MALADIES GENETIQUES NECKER ENFANTS MALADES, ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS, UNIVERSITE PARIS DESCARTES
    Inventors: Yves Colin, Jean-Francois Girmens, Olivier Hermine, Emmanuel Heron, Michel Paques
  • Publication number: 20180221313
    Abstract: The present invention relates to the use of hydroxycarbamide (HC) for reducing and/or delaying the extension of capillary nonperfusion, a cause of irreparable visual impairment in patients suffering from central retinal vein occlusion (CRVO). This is the first systemic treatment which makes it possible to reduce retinal ischemic complications in patients in whom (CRVO) has been recently diagnosed and is consequently in a rapidly progressive phase. Given the low toxicity of HC evaluated on a large scale in children and adults in the context of other diseases for decades, the results of the present study open up a new therapeutic approach in the treatment of CRVO.
    Type: Application
    Filed: August 8, 2016
    Publication date: August 9, 2018
    Applicant: Centre National De La Recherche Scientifique (CNRS)
    Inventors: Yves COLIN, Jean-Francois GIRMENS, Olivier HERMINE, Emmanuel HERON, Michel PAQUES
  • Patent number: 9308125
    Abstract: The present technology relates to an apparatus for intraocular injection comprising a plate adapted for being brought into contact with an eye and a guide operable to guide a needle into the interior of an eye, characterized in that it comprises means for displacing a superficial layer (1) of the eye over an underlying layer (2) of the eye as the plate is brought into contact with the eye before the needle is guided into the interior of the eye.
    Type: Grant
    Filed: January 9, 2008
    Date of Patent: April 12, 2016
    Assignees: FOVEA PHARMACEUTICALS, FONDATION OPHTALMOLOGIQUEADOLPHE DE ROTHSCHILD
    Inventors: Michel Paques, Pierre Roy
  • Patent number: 8808242
    Abstract: The invention relates to an apparatus for injection into an eye comprising of a means for displacing a conjunctival layer of the eye over an underlying scleral layer of the eye so as to form a fold in the conjunctival layer, and means for guiding a needle through the conjunctival layer once the fold has been formed.
    Type: Grant
    Filed: November 2, 2011
    Date of Patent: August 19, 2014
    Assignee: Fovea Pharmaceuticals
    Inventors: Michel Paques, Pierre Roy
  • Publication number: 20140073916
    Abstract: The invention relates to a device for assisting in detecting anatomical features of at least a portion of a tissue, in particular a retinal tissue, the device comprising means for acquiring images of said portion using optical coherence tomography (OCT), which are taken at separate angles of incidence, and detection means for detecting, in a single area of the portion studied, at least one pattern having at least one feature that varies from one image to another, the pattern being attributable to the presence of anatomical features. The invention likewise relates to a method for assisting in detecting anatomical features of at least a portion of a tissue.
    Type: Application
    Filed: April 10, 2012
    Publication date: March 13, 2014
    Applicant: UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)
    Inventors: Michel Paques, Sarah Mrejen
  • Publication number: 20130211335
    Abstract: The invention relates to an apparatus for injection into an eye comprising of a means for displacing a conjunctival layer of the eye over an underlying scleral layer of the eye so as to form a fold in the conjunctival layer, and means for guiding a needle through the conjunctival layer once the fold has been formed.
    Type: Application
    Filed: November 2, 2011
    Publication date: August 15, 2013
    Applicant: FOVEA Pharmaceuticals
    Inventors: Michel Paques, Pierre Roy
  • Patent number: 8460242
    Abstract: The application relates to an apparatus for intraocular injection comprising a plate adapted for being brought into contact with an eye and guiding means for guiding a needle into the interior of an eye, characterized in that the plate comprises a cut-out having an edge adapted to be positioned along the limbus delimiting the cornea and the sclera of the eye, so as to adjust the position of the guiding means with respect to the limbus.
    Type: Grant
    Filed: January 9, 2008
    Date of Patent: June 11, 2013
    Assignees: Fovea Pharmaceuticals, Foundation Ophtalmologiqueadolphe de Rothschild
    Inventors: Michel Paques, Pierre Roy
  • Publication number: 20100030150
    Abstract: The application relates to an apparatus for intraocular injection comprising a plate adapted for being brought into contact with an eye and guiding means for guiding a needle into the interior of an eye, characterized in that the plate comprises a cut-out having an edge adapted to be positioned along the limbus delimiting the cornea and the sclera of the eye, so as to adjust the position of the guiding means with respect to the limbus.
    Type: Application
    Filed: January 9, 2008
    Publication date: February 4, 2010
    Applicants: FOVEA PHARMACEUTICALS, FONDATION OPHTALMOLOGIQUE ADOLPHE DE ROTHSCHILD
    Inventors: Michel Paques, Pierre Roy
  • Publication number: 20100010452
    Abstract: The present technology relates to an apparatus for intraocular injection comprising a plate adapted for being brought into contact with an eye and a guide operable to guide a needle into the interior of an eye, characterized in that it comprises means for displacing a superficial layer (1) of the eye over an underlying layer (2) of the eye as the plate is brought into contact with the eye before the needle is guided into the interior of the eye.
    Type: Application
    Filed: January 9, 2008
    Publication date: January 14, 2010
    Applicants: FOVEA PHARMACEUTICALS, FOUDATION OPHTALMOLOGIQUE ADOLPHE DE ROTHSCHILD
    Inventors: Michel Paques, Pierre Roy
  • Publication number: 20090292021
    Abstract: Pharmaceutical compositions including, as the active ingredients, a combination of vigabatrin and of at least one substance having anti-ischemic effect, are disclosed.
    Type: Application
    Filed: July 31, 2007
    Publication date: November 26, 2009
    Applicant: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA REC
    Inventors: Serge Picaud, Agnes Duboc, Michel Paques, Jose Sahel, Manuel Simonutti
  • Publication number: 20050118945
    Abstract: Device for transmitting energy in a system for cabled telecommunication. The system comprises first and second pairs of telecommunication wires (TP). The device comprises a central module or base station arranged to be connected to an electrical energy source and for the first and second pairs of wires to be connected thereto. A satellite comprises a first satellite converter. The first satellite converter comprises a first input arranged for the first pair of wires to be connected thereto and a second input arranged for the second pair of wires to be connected thereto.
    Type: Application
    Filed: November 18, 2004
    Publication date: June 2, 2005
    Inventors: Fabrice Frebel, Michel Paque, Paul Bleus
  • Publication number: 20030171722
    Abstract: A microsurgical injection instrument particularly useful by a physician for injecting a liquid substance or a suspension into a blood vessel in the retina of a subject's eye, includes a handpiece carrying a hollow needle at its distal end, for penetrating the blood vessel. The longitudinal axis of the distal end of the handpiece and of the needle is at an angle of from 90°-180°, preferably about 145°, to the longitudinal axis of the proximal end of the handpiece to facilitate orienting the needle substantially tangentially to the plane of the subject's retina coaxially to a blood vessel for penetrating the blood vessel. The instrument may also be used to treat an occluded blood vessel by moving a flexible tube through the hollow needle, after the needle has penetrated the blood vessel, to enter and catheterize the blood vessel.
    Type: Application
    Filed: February 27, 2003
    Publication date: September 11, 2003
    Inventors: Michel Paques, Nathanael Benhamou
  • Publication number: 20020087128
    Abstract: A microsurgical injection instrument particularly useful by a physician for injecting a liquid substance or a suspension into a blood vessel in the retina of a subject's eye, includes a handpiece carrying a hollow needle at its distal end, for penetrating the blood vessel. The longitudinal axis of the distal end of the handpiece and of the needle is at an angle of from 120° to 80°, preferably about 145°, to the longitudinal axis of the proximal end of the handpiece to facilitate orienting the needle substantially tangentially to the plane of the subject's retina for penetrating the blood vessel. The instrument may also be used to treat an occluded blood vessel by moving a flexible tube through the hollow needle, after the needle has penetrated the blood vessel, to enter and catheterize the blood vessel.
    Type: Application
    Filed: January 4, 2001
    Publication date: July 4, 2002
    Applicant: MPNB Ltd.
    Inventors: Michel Paques, Nathanael Benhamou