Patents by Inventor Michel Revel

Michel Revel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR DIFFERENTIATING AND PURIFYING PANCREATIC ENDOCRINE CELLS
    Publication number: 20230248779
    Abstract: The present invention relates to compositions and methods comprising cell surface markers for pluripotent-derived cells, in particular, pancreatic endoderm-type cells, derived from pluripotent stem cells.
    Type: Application
    Filed: April 21, 2023
    Publication date: August 10, 2023
    Applicants: Kadimastem Ltd., Yeda Research and Development Co. Ltd.
    Inventors: Kfir MOLAKANDOV, Neta LAVON, Avital BECK, Michel REVEL, Ofer ELHANANI, Yoav SOEN, Michael WALKER, Arye HASSON
  • Methods for differentiating and purifying pancreatic endocrine cells
    Patent number: 11679133
    Abstract: The present invention relates to compositions and methods comprising cell surface markers for pluripotent-derived cells, in particular, pancreatic endoderm-type cells, derived from pluripotent stem cells.
    Type: Grant
    Filed: November 28, 2016
    Date of Patent: June 20, 2023
    Assignees: Kadimastem Ltd., Yeda Research and Development Co. Ltd.
    Inventors: Kfir Molakandov, Neta Lavon, Avital Beck, Michel Revel, Ofer Elhanani, Yoav Soen, Michael Walker, Arik Hasson
  • METHODS OF TREATING ACUTE RESPIRATORY DISTRESS SYNDROME
    Publication number: 20220387514
    Abstract: A method of treating acute respiratory distress syndrome (ARDS) in a subject in need thereof is provided. The method comprising administering to the subject a composition comprising a therapeutically effective amount of astrocytes, thereby treating the ARDS.
    Type: Application
    Filed: June 2, 2022
    Publication date: December 8, 2022
    Applicant: Kadimastem Ltd.
    Inventors: Michel REVEL, Michal IZRAEL, Julia Miriam WEISS, Kfir MOLAKANDOV
  • Methods of generating glial and neuronal cells and use of same for the treatment of medical conditions of the CNS
    Patent number: 11406670
    Abstract: A method of generating neural and glial cells is provided. The method comprising growing human stem cells under conditions which induce differentiation of said human stem cells into the neural and glial cells, said conditions comprising the presence of retinoic acid and an agent capable of down-regulating Bone Morphogenic Protein activity.
    Type: Grant
    Filed: February 21, 2019
    Date of Patent: August 9, 2022
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Michel Revel, Judith Chebath, Michal Izrael, Rosalia Kaufman
  • DIRECTED DIFFERENTIATION OF ASTROCYTES FROM HUMAN PLURIPOTENT STEM CELLS FOR USE IN DRUG SCREENING AND THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS (ALS)
    Publication number: 20210054334
    Abstract: The present invention discloses a method of identifying agents that affect human astrocytes functionality using ex-vivo differentiated pluripotent stem cells (PSC). In addition, the use of human progenitor astrocytes or human astrocytes for the treatment of Amyotrophic Lateral Sclerosis (ALS) in a human subject is also disclosed.
    Type: Application
    Filed: September 9, 2019
    Publication date: February 25, 2021
    Applicant: Kadimastem Ltd.
    Inventors: Michal Izrael, Michel Revel, Arik Hasson, Kfir Molakandov, Judith Chebath
  • METHOD OF IDENTIFYING AGENTS THAT AFFECT MATURATION, SURVIVAL AND MYELINATION
    Publication number: 20200003757
    Abstract: The present invention discloses a method of identifying agents that affect maturation and survival of oligodendrocytes or myelination of neuronal cells using ex-vivo differentiated embryonic stem cells.
    Type: Application
    Filed: July 15, 2019
    Publication date: January 2, 2020
    Applicant: KADIMASTEM, LTD.
    Inventors: Michel Revel, Judith Chebath, Arye Hasson, Michal Izrael, Rosalia Kaufman
  • METHODS OF GENERATING GLIAL AND NEURONAL CELLS AND USE OF SAME FOR THE TREATMENT OF MEDICAL CONDITIONS OF THE CNS
    Publication number: 20190175658
    Abstract: A method of generating neural and glial cells is provided. The method comprising growing human stem cells under conditions which induce differentiation of said human stem cells into the neural and glial cells, said conditions comprising the presence of retinoic acid and an agent capable of down-regulating Bone Morphogenic Protein activity.
    Type: Application
    Filed: February 21, 2019
    Publication date: June 13, 2019
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Michel Revel, Judith Chebath, Michal Izrael, Rosalia Kaufman
  • Methods of generating glial and neuronal cells and use of same for the treatment of medical conditions of the CNS
    Patent number: 10258651
    Abstract: A method of generating neural and glial cells is provided. The method comprising growing human stem cells under conditions which induce differentiation of said human stem cells into the neural and glial cells, said conditions comprising the presence of retinoic acid and an agent capable of down-regulating Bone Morphogenic Protein activity.
    Type: Grant
    Filed: March 23, 2017
    Date of Patent: April 16, 2019
    Assignee: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
    Inventors: Michel Revel, Judith Chebath, Michal Izrael, Rosalia Kaufman
  • Methods for Differentiating and Purifying Pancreatic Endocrine Cells
    Publication number: 20180369290
    Abstract: The present invention relates to compositions and methods comprising cell surface markers for pluripotent-derived cells, in particular, pancreatic endoderm-type cells, derived from pluripotent stem cells.
    Type: Application
    Filed: November 28, 2016
    Publication date: December 27, 2018
    Inventors: Kfir MOLAKANDOV, Neta LAVON, Avital BECK, Michel REVEL, Ofer ELHANANI, Yoav SOEN, Michael WALKER, Arik HASSON
  • DIRECTED DIFFERENTIATION OF ASTROCYTES FROM HUMAN PLURIPOTENT STEM CELLS FOR USE IN DRUG SCREENING AND THE TREATMENT OF AMYOTROPHIC LATERIAL SCLEROSIS (ALS)
    Publication number: 20180230427
    Abstract: The present invention discloses a method of identifying agents that affect human astrocytes functionality using ex-vivo differentiated pluripotent stem cells (PSC). In addition, the use of human progenitor astrocytes or human astrocytes for the treatment of Amyotrophic Lateral Sclerosis (ALS) in a human subject is also disclosed.
    Type: Application
    Filed: January 5, 2018
    Publication date: August 16, 2018
    Applicant: Kadimastem Ltd.
    Inventors: Michal Izrael, Michel Revel, Arik Hasson, Kfir Molakandov, Judith Chebath
  • METHODS OF GENERATING GLIAL AND NEURONAL CELLS AND USE OF SAME FOR THE TREATMENT OF MEDICAL CONDITIONS OF THE CNS
    Publication number: 20170362570
    Abstract: A method of generating neural and glial cells is provided. The method comprising growing human stem cells under conditions which induce differentiation of said human stem cells into the neural and glial cells, said conditions comprising the presence of retinoic acid and an agent capable of down-regulating Bone Morphogenic Protein activity.
    Type: Application
    Filed: March 23, 2017
    Publication date: December 21, 2017
    Inventors: Michel Revel, Judith Chebath, Michal Izrael, Rosalia Kaufman
  • Methods of generating glial and neuronal cells and use of same for the treatment of medical conditions of the CNS
    Patent number: 9631175
    Abstract: A method of generating neural and glial cells is provided. The method comprising growing human stem cells under conditions which induce differentiation of said human stem cells into the neural and glial cells, said conditions comprising the presence of retinoic acid and an agent capable of down-regulating Bone Morphogenic Protein activity.
    Type: Grant
    Filed: July 11, 2014
    Date of Patent: April 25, 2017
    Assignee: Yeda Research and Development Co. Ltd. at the Weizmann Institute of Science
    Inventors: Michel Revel, Judith Chebath, Michal Izrael, Rosalia Kaufman
  • METHODS OF INDUCING MYELINATION AND MATURATION OF OLIGODENDROCYTES
    Publication number: 20170095512
    Abstract: The present invention disclosed methods of inducing maturation of oligodendrocyte cells.
    Type: Application
    Filed: June 2, 2015
    Publication date: April 6, 2017
    Inventors: Michal Izrael, Michel Revel, Arik Hasson, Judith Chebath
  • DIRECTED DIFFERENTIATION OF ASTROCYTES FROM HUMAN PLURIPOTENT STEM CELLS FOR USE IN DRUG SCREENING AND THE TREATMENT OF AMYOTROPHIC LATERIAL SCLEROSIS (ALS)
    Publication number: 20160237404
    Abstract: The present invention discloses a method of identifying agents that affect human astrocytes functionality using ex-vivo differentiated pluripotent stem cells (PSC). In addition, the use of human progenitor astrocytes or human astrocytes for the treatment of Amyotrophic Lateral Sclerosis (ALS) in a human subject is also disclosed.
    Type: Application
    Filed: September 23, 2014
    Publication date: August 18, 2016
    Inventors: Michal IZRAEL, Michel REVEL, Arik HASSON, Kfir MOLAKANDOV, Judith CHEBATH
  • Insulin producing cells derived from pluripotent stem cells
    Patent number: 9404087
    Abstract: A method of generating islet cells from pluripotent stem cells is disclosed. The method comprises: (a) culturing the pluripotent stem cells in a differentiation medium so as to differentiate the pluripotent stem cells into endoderm cells; and (b) culturing the endoderm cells in a medium comprising at least one growth factor, a cAMP inducer and retinoic acid (RA), said at least one growth factor being selected from the group consisting of FGF10, bFGF and FGF7 so as to generate further differentiated cells; and (c) culturing the further differentiated cells in a medium comprising a maturation factor selected from the group consisting of nicotinamide, GLP-1 and exendin 4, thereby generating islet cells from pluripotent stem cells. Further methods of generating islet cells are also disclosed, isolated cell populations comprising same and uses thereof.
    Type: Grant
    Filed: December 15, 2011
    Date of Patent: August 2, 2016
    Assignee: Kadimastem Ltd.
    Inventors: Michel Revel, Judith Chebath, Guy Slutsky, Alon Levy, Michal Izrael, Arik Hasson, Kfir Molakandov, Rosalia Kaufman
  • METHODS OF GENERATING GLIAL AND NEURONAL CELLS AND USE OF SAME FOR THE TREATMENT OF MEDICAL CONDITIONS OF THE CNS
    Publication number: 20140322179
    Abstract: A method of generating neural and glial cells is provided. The method comprising growing human stem cells under conditions which induce differentiation of said human stem cells into the neural and glial cells, said conditions comprising the presence of retinoic acid and an agent capable of down-regulating Bone Morphogenic Protein activity.
    Type: Application
    Filed: July 11, 2014
    Publication date: October 30, 2014
    Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
    Inventors: Michel Revel, Judith Chebath, Michal Izrael, Rosalia Kaufman
  • METHOD OF IDENTIFYING AGENTS THAT AFFECT MATURATION, SURVIVAL AND MYELINATION
    Publication number: 20140296107
    Abstract: The present invention discloses a method of identifying agents that affect maturation and survival of oligodendrocytes or myelination of neuronal cells using ex-vivo differentiated embryonic stem cells.
    Type: Application
    Filed: August 5, 2012
    Publication date: October 2, 2014
    Applicant: KADIMASTEM, LTD.
    Inventors: Michel Revel, Judith Chebath, Arye Hasson, Michal Izrael, Rosalia Kaufman
  • Methods of generating mature oligodendrocytes
    Patent number: 8809052
    Abstract: A method of generating neural and glial cells is provided. The method comprising growing human stem cells under conditions which induce differentiation of said human stem cells into the neural and glial cells, said conditions comprising the presence of retinoic acid and an agent capable of down-regulating Bone Morphogenic Protein activity.
    Type: Grant
    Filed: August 15, 2007
    Date of Patent: August 19, 2014
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Michel Revel, Judith Chebath, Michal Izrael, Rosalia Kaufman
  • Method of generating oligodendrocytes from neurosphere cells
    Patent number: 8617887
    Abstract: The present invention is generally in the field of neurological diseases and disorders, particular in the field of neurodegenerative diseases in which the myelin cover of nerves is lost. IL6R/IL6 chimera is used to promote the formation of oligodendrocytes from embryonic stem cells for treatment of neurodegenerative diseases or posttraumatic nerve damage.
    Type: Grant
    Filed: June 13, 2004
    Date of Patent: December 31, 2013
    Assignee: Yeda Research and Development Co. Ltd
    Inventors: Michel Revel, Peter Lonai, Rozemari Stirbu Lonai
  • INSULIN PRODUCING CELLS DERIVED FROM PLURIPOTENT STEM CELLS
    Publication number: 20130273013
    Abstract: A method of generating islet cells from pluripotent stem cells is disclosed. The method comprises: (a) culturing the pluripotent stem cells in a differentiation medium so as to differentiate the pluripotent stem cells into endoderm cells; and (b) culturing the endoderm cells in a medium comprising at least one growth factor, a cAMP inducer and retinoic acid (RA), said at least one growth factor being selected from the group consisting of FGF10, bFGF and FGF7 so as to generate further differentiated cells; and (c) culturing the further differentiated cells in a medium comprising a maturation factor selected from the group consisting of nicotinamide, GLP-1 and exendin 4, thereby generating islet cells from pluripotent stem cells. Further methods of generating islet cells are also disclosed, isolated cell populations comprising same and uses thereof.
    Type: Application
    Filed: December 15, 2011
    Publication date: October 17, 2013
    Inventors: Michel Revel, Judith Chebath, Guy Slutsky, Alon Levy, Michal Izrael, Arik Hasson, Molakandov Kfir, Rosalia Kaufman