Patents by Inventor Michel Roberge
Michel Roberge has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10300055Abstract: Methods are provided for the treatment of Parkinson's disease (PD) in patients bearing mutations in the LRRK2 gene. A therapeutically effective amount of piperazine derivative compounds are employed to inhibit the biological activity of ArfGAP1, inhibition that counteracts the deleterious effects of mutations in, or increased expression of, the LRRK2 protein.Type: GrantFiled: April 10, 2015Date of Patent: May 28, 2019Assignee: DALHOUSIE UNIVERSITYInventors: Michel Roberge, Chris McMaster, Carla Zimmerman, Pak Poon
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Publication number: 20180258123Abstract: This invention discloses the use of aminoglycoside antibiotics such as gentamicin B1 to suppress premature termination codons during translation and promote the full length read-through of transcripts such as p53 that incorporate nonsense mutations and to treat disease conditions such as cancer caused by such genetic mutations.Type: ApplicationFiled: September 23, 2016Publication date: September 13, 2018Inventors: Michel Roberge, Alireza Baradaran-Heravi, Carla D. Zimmerman, Aruna Dinesh Balgi, Stephen G. Withers, Kunho Choi
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TREATMENT OF PARKINSON'S DISEASE THROUGH ARFGAP1 INHIBITION USING SUBSTITUTED PIPERAZINE DERIVATIVES
Publication number: 20170020866Abstract: Methods are provided for the treatment of Parkinson's disease (PD) in patients bearing mutations in the LRRK2 gene. A therapeutically effective amount of piperazine derivative compounds are employed to inhibit the biological activity of ArfGAP1, inhibition that counteracts the deleterious effects of mutations in, or increased expression of, the LRRK2 protein.Type: ApplicationFiled: April 10, 2015Publication date: January 26, 2017Inventors: Michel Roberge, Chris McMaster, Carla Zimmerman, Pak Poon -
COMPOSITIONS AND METHODS FOR ENHANCING CELLULAR UPTAKE AND INTRACELLULAR DELIVERY OF LIPID PARTICLES
Publication number: 20120264810Abstract: Compositions, methods and compounds useful for enhancing the uptake of a lipid particle b\ a cell are described In particular embodiments, the methods of the invention include contacting a cell with a lipid particle and a compound that binds a Na+/K+ ATPase to enhance uptake of the lipid particle b\ the cell Related compositions useful in practicing methods include lipid particles comprising a conjugated compound that enhances uptake of the lipid particles b\ the cell The methods and compositions are useful in delivering a therapeutic agent to a cell, e g for the treatment of a disease or disorder in a subjectType: ApplicationFiled: September 22, 2010Publication date: October 18, 2012Applicant: The University of British ColumbiaInventors: Paulo J.C. Lin, Yuen Yi c. Tam, Srinivasulu Masuna, Marco A. Ciufolini, Michel Roberge, Pieter R. Cullis -
Patent number: 7799776Abstract: Inhibitors of indoleamine 2,3-dioxygenase (IDO) are provided as are pharmaceutical compositions containing such inhibitors as well as the use of such inhibitors and compositions for the treatment of a condition in a mammalian subject characterized by pathology of the IDO-mediated tryptophan metabolic pathway. Such conditions may involve suppression of T-cell mediated immune response or may directly result from depletion of tryptophan or accumulation of a product of tryptophan degradation. Specific disease conditions include cataracts, age-related yellowing in the eye, neurodegenerative disorders, mood disorders, cancer and various bacterial/viral infections. IDO inhibitors of this invention are substituted naphthalene and anthracene diones. Novel compounds of this invention include the following taurine-substituted naphthaquinone structure.Type: GrantFiled: July 13, 2005Date of Patent: September 21, 2010Assignee: The University of British ColumbiaInventors: Raymond J. Andersen, Alban Pereira, Xin-Hui Huang, Grant Mauk, Eduardo Vottero, Michel Roberge, Aruna Balgi
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Patent number: 7772397Abstract: This invention relates to derivatives of hemiasterlin or Geodiamolide G having anti-mitotic activities and useful in treating cancer. These derivatives are represented by general formula I, wherein Y, n, R1, R2, R3, R6, R7, R70, R71, R72, R74, and R75 are as defined in the specification.Type: GrantFiled: July 21, 2008Date of Patent: August 10, 2010Assignee: University of British ColumbiaInventors: Raymond Andersen, John Coleman, Dilip De Silva, Fangming Kong, Edward Piers, Debra Wallace, Michel Roberge, Theresa Allen
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Publication number: 20090264487Abstract: This invention provides analogs of hemiasterlin, methods of synthesis of the analogs and use of the analogs as a cytotoxic anti-mitotic agents.Type: ApplicationFiled: June 25, 2009Publication date: October 22, 2009Applicant: THE UNIVERSITY OF BRITISH COLUMBIAInventors: Raymond ANDERSEN, Edward Piers, James Nieman, John Coleman, Michel Roberge
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Patent number: 7579323Abstract: This invention provides analogs of hemiasterlin, methods of synthesis of the analogs and use of the analogs as cytotoxic and anti-mitotic agents.Type: GrantFiled: December 13, 1998Date of Patent: August 25, 2009Assignee: The University of British ColumbiaInventors: Raymond Andersen, Edward Piers, James Nieman, John Coleman, Michel Roberge
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Publication number: 20090088573Abstract: This invention relates to derivatives of hemiasterlin or Geodiamolide G having anti-mitotic activities and useful in treating cancer. These derivatives are represented by general formula I, wherein Y, n, R1, R2, R3, R6, R7, R70, R71, R72, R74, and R75 are as defined in the specification.Type: ApplicationFiled: July 21, 2008Publication date: April 2, 2009Applicant: The University of British ColumbiaInventors: Raymond ANDERSEN, John Coleman, Dilip De Silva, Fangming Kong, Edward Piers, Debra Wallace, Michel Roberge, Theresa Allen
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Publication number: 20090042868Abstract: Inhibitors of indoleamine 2,3-dioxygenase (IDO) are provided as are pharmaceutical compositions containing such inhibitors as well as the use of such inhibitors and compositions for the treatment of a condition in a mammalian subject characterized by pathology of the IDO-mediated tryptophan metabolic pathway. Such conditions may involve suppression of T-cell mediated immune response or may directly result from depletion of tryptophan or accumulation of a product of tryptophan degradation. Specific disease conditions include cataracts, age-related yellowing in the eye, neurodegenerative disorders, mood disorders, cancer and various bacterial/viral infections. IDO inhibitors of this invention are substituted naphthalene and anthracene diones. Novel compounds of this invention include the following taurine-substituted naphthaquinone structure.Type: ApplicationFiled: July 13, 2005Publication date: February 12, 2009Applicant: THE UNIVERSITY OF BRITISH COLUMBIAInventors: Raymond J. ANDERSEN, Alban PEREIRA, Xin-Hui HUANG, Grant MAUK, Eduardo VOTTERO, Michel ROBERGE, Aruna BALGI
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Publication number: 20080255090Abstract: Antimitotic compounds and salts are provided in which the compound has the structure (formula (I)): wherein X and Y are substituted or unsubstituted and are selected from carbon atoms and atoms of groups 15 and 16 of the periodic table; Z is selected from N—R, O and S; U is selected from CR1, N, NH, NR, S and O, R1, R2, and R3 are independently selected from H, NH2, NHR, NR2, SH, SR, SiR3, OH, OR, F, CI, Br, I, ?O, ?S and R; W is selected from O, S, and H2; R4 is selected from H, R, OH, OR, SH, SR, NH2, NHR, NR2 and halide; R is selected from H, substituted or unsubstituted aryl, and substituted or unsubstituted 1 to 20 carbon linear, branched, or cyclic, saturated or unsaturated alkyl, in which alkyl carbon atoms are replaced by 0 to 10 oxygen, 0 to 10 sulphur, and 0 to 10 N atoms; and wherein bonds to carbon atoms or to any of X, Y, Z and U are saturated or unsaturated; and providing that when W is H2, R4 is not H, OH, or unsubstituted phenyl.Type: ApplicationFiled: September 15, 2004Publication date: October 16, 2008Applicant: THE UNIVERSITY OF BRITISH COLUMBIAInventors: Raymond J. Andersen, Michel Roberge, Emiliano Manzo
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Patent number: 7410951Abstract: Derivatives of hemiasterlin or Geodiamolide G having anti-mitotic activities and useful in treating cancer. These derivatives are represented by formula I wherein Y, n, R1, R2, R3, R7, R70, R71, R72, R74, and R75 are as defined in the specification.Type: GrantFiled: January 14, 2005Date of Patent: August 12, 2008Assignee: The University of British ColumbiaInventors: Raymond Andersen, John Coleman, Dilip De Silva, Fangming Kong, Edward Piers, Debra Wallace, Michel Roberge, Theresa Allen
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Patent number: 7067494Abstract: This invention provides analogs of eleutherobin and the eleuthesides modified at the C-11 position or comprising an epoxide functionality from C-11 to C-12. C-11 to C-12 is an ideal location for conjugating functional moieties to the eleutherobin pharmacophore without significant loss of antimitotic activity. Moieties that may be conjugated at C-11 include those intended to increase the solubility of the pharmacophore, to facilitate drug formulation, or to facilitate in vivo delivery or targeting.Type: GrantFiled: June 25, 2002Date of Patent: June 27, 2006Assignee: The University of British ColumbiaInventors: Raymond J. Andersen, Michel Roberge, Robert A. Britton, E. Dilip De Silva
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Publication number: 20060014727Abstract: The invention provides sterol sulphate compounds and compositions that are capable of promoting angiogenesis. The invention also provides methods and uses for these compounds.Type: ApplicationFiled: June 20, 2005Publication date: January 19, 2006Inventors: Aly Karsan, Michel Roberge, Raymond Andersen, Ingrid Pollet
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Publication number: 20050222126Abstract: This invention provides the use of macrocyclic amines for inhibition of cellular invasion or angiogenesis. Compounds and pharmaceutical compositions of this invention are useful in the treatment of conditions characterized by cellular invasion or angiogenesis, including cancer. Compounds that may be used in this invention include the motuporamines.Type: ApplicationFiled: February 28, 2005Publication date: October 6, 2005Inventors: Calvin Roskelley, Raymond Andersen, David Williams, Michel Roberge, Shoukat Dedhar, Aly Karsan, Andrew Minchinton
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Publication number: 20040266700Abstract: This invention provides analogs of eleutherobin and the eleuthesides modified at the C-11 position or comprising an epoxide functionality from C-11 to C-12. C-11 to C-12 is an ideal location for conjugating functional moieties to the eleutherobin pharmacophore without significant loss of antimitotic activity. Moieties that may be conjugated at C-11 include those intended to increase the solubility of the pharmacophore, to facilitate drug formulation, or to facilitate in vivo delivery or targeting.Type: ApplicationFiled: April 7, 2004Publication date: December 30, 2004Inventors: Raymond J Andersen, Michel Roberge, Robert A. Britton, E. Dilip De Silva
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Patent number: 6812037Abstract: Antimitotic terpenoid compounds including sarcodictyin A and as eleutherobin may be obtained from organisms of the order Gorgonacea. Methods of preparing such compounds provided, as are novel antimitotic diterpene compounds having formula (I).Type: GrantFiled: November 7, 2002Date of Patent: November 2, 2004Assignee: The University of British ColumbiaInventors: Raymond J. Andersen, Michel Roberge, Bruno Cinel
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Publication number: 20030004149Abstract: This invention provides the use of macrocyclic amines for inhibition of cellular invasion or angiogenesis. Compounds and pharmaceutical compositions of this invention are useful in the treatment of conditions characterized by cellular invasion or angiogenesis, including cancer. Compounds that may be used in this invention include the motuporamines.Type: ApplicationFiled: January 25, 2002Publication date: January 2, 2003Inventors: Calvin Roskelley, Raymond Andersen, David Williams, Michel Roberge, Shoukat Dedhar, Aly Karsan, Andrew Minchinton
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Patent number: 6291447Abstract: Novel granulatimide compounds and pharmaceutical formulations thereof are provided.Type: GrantFiled: February 26, 1999Date of Patent: September 18, 2001Assignees: The University of British Columbia, Kinetek Pharmaceuticals, Inc.Inventors: Raymond Andersen, Michel Roberge, Jasbinder Sanghera, Daniel Leung, Edward Piers, Roberto GS Berlinck, Robert Britton
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Patent number: 6153590Abstract: Compounds of general formula I ##STR1## wherein: R.sub.1 and R.sub.70 independently represent a hydrogen atom or an optionally substituted alkyl or acyl group; R.sub.2 represents a hydrogen atom or an optionally substituted alkyl or acyl group or is absent when R.sub.6 represents a group --CH.dbd. as hereinafter described; R.sub.73 represents a hydrogen atom or an optional substituent or is absent when R.sub.6 represents a methylene group or a group --CH.dbd. as hereinafter described; Y represents an optional substituent; n represents 0, 1, 2, 3, or 4; R.sub.3 represents a hydrogen atom, or an optionally substituted alkyl group; R.sub.74 represents a hydrogen atom, a hydroxy group or an optionally substituted alkyl or acyl group; R.sub.7 represents a hydrogen atom or an alkyl group; R.sub.75 represents an optionally substituted alkyl group; and i) R.sub.6 and R.sub.71 independently represent a hydrogen atom or an optionally substituted alkyl or acyl group; and R.sub.72 represents a hydrogen atom; or ii) R.Type: GrantFiled: February 2, 1998Date of Patent: November 28, 2000Assignees: University of Alberta, University of British ColumbiaInventors: Raymond Andersen, John Coleman, Dilip De Silva, Fangming Kong, Edward Piers, Debra Wallace, Michel Roberge, Teresa Allen