Abstract: There is described a drum coater including a substantially cylindrical drum having a peripheral drum wall and a predefined diameter, said drum having a substantially horizontal axis of rotation, a top section and a bottom section being defined above and below, respectively, the axis of rotation, said drum being adapted to contain tablets, a coating zone, one or more spray nozzles directed towards the coating zone, and driving means.

Abstract: The drum coater comprises a substantially cylindrical drum (11) with a peripheral wall and a substantially horizontal axis of rotation. The method comprises providing a coating zone within the drum, feeding tablets into the drum, spinning the drum containing the tablets at a rotational speed such that a substantially annular bed of tablets is created, providing means for creating a cascade (19) of tablets at least in a part of the coating zone and spraying the tablets in the coating zone.

Abstract: A method for continuous production of tablets, including providing a contained module comprising at least two inlets, at least one mixing unit, at least one analytical sensor, a tablet press, and at least one outlet for tablets, feeding an active pharmaceutical ingredient (API) to one of the at least two inlets, feeding an excipient to the other of the at least two inlets, mixing the material stream comprising the API and the excipient in the at least one mixing unit, measuring parameters of the contents of the material stream with the at least one analytical sensor upstream of the tablet press, controlling the two inlets and/or the mixing unit in response to the parameters measured, continuously supplying the tablet press with the material stream, controlling the speed of the tablet press in response to the parameters measured upstream of the tablet press, and discharging tablets at the at least one outlet.

Abstract: The contained module (1) comprises inlets for an active pharmaceutical ingredient (API) and for an excipient. The inlets are in fluid communication with at least one mixing unit (41,46), and the outlet of the tablet press (6) is in fluid communication with the releasable outlet port for tablets. The material stream comprising the API and the excipient is mixed in the mixing units. During operation parameters of the contents of the material stream are measured with one or more analytical sensors upstream of the tablet press. The speed of the tablet press is controlled in response to the parameters measured upstream of the tablet press. The finished tablets are discharged at an outlet of the tablet press (6).

Abstract: The tabletting system (1) comprises a rotary tablet press (6) with a tablet press feeder (67). A first material feeder (21) and a second material feeder (22) are connected to a blender (4) with an inlet end (40) and a discharge end (45). The discharge end (45) of the blender is in close connection with the tablet press. The inlet end (40) of the blender (4) is positioned at a level (u) higher than the level (v) of the discharge end (45) in the vertical direction.

Abstract: A method for continuous production of tablets, including providing a contained module comprising at least two inlets, at least one mixing unit, at least one analytical sensor, a tablet press, and at least one outlet for tablets, feeding an active pharmaceutical ingredient (API) to one of the at least two inlets, feeding an excipient to the other of the at least two inlets, mixing the material stream comprising the API and the excipient in the at least one mixing unit, measuring parameters of the contents of the material stream with the at least one analytical sensor upstream of the tablet press, controlling the two inlets and/or the mixing unit in response to the parameters measured, continuously supplying the tablet press with the material stream, controlling the speed of the tablet press in response to the parameters measured upstream of the tablet press, and discharging tablets at the at least one outlet.

Abstract: The tabletting system (1) comprises a rotary tablet press (6) with a tablet press feeder (67). A first material feeder (21) and a second material feeder (22) are connected to a blender (4) with an inlet end (40) and a discharge end (45). The discharge end (45) of the blender is in close connection with the tablet press. The inlet end (40) of the blender (4) is positioned at a level (u) higher than the level (v) of the discharge end (45) in the vertical direction.

Abstract: A continuous granulator comprises a longitudinal granulation chamber having a first end with an inlet for powder material and a binder feed port and a second end with an outlet for granulated product. The granulation chamber comprises at least two parallel rotary shafts provided with granulating elements and forming an angle of from 0 to 70 degrees with the vertical. Each granulating element on a shaft comprises at least one lobe having limited extent in the circumferential direction of the shaft and interleaving with a lobe of a granulating element on another shaft. A plurality of such separate granulating elements are distributed from the inlet to the outlet, and successive granulating elements on a shaft are mutually angled.

Abstract: The drum coater comprises a substantially cylindrical drum (11) with a peripheral wall and a substantially horizontal axis of rotation. The method comprises providing a coating zone within the drum, feeding tablets into the drum, spinning the drum containing the tablets at a rotational speed such that a substantially annular bed of tablets is created, providing means for creating a cascade (19) of tablets at least in a part of the coating zone and spraying the tablets in the coating zone.

Abstract: A rotary tablet press comprises a housing and a rotary die table having dies arranged circumferentially. Each die is associated with a punch having an end receivable in the die and being arranged for compression of a powder or granular material in the die by reciprocation of the punch by rotation of the die table. The rotary tablet press comprises a feeding device and a tablet discharge device. Each die opening and its corresponding punch end are enclosed in a compression chamber comprising a dust extraction nozzle. The compression chamber communicates with the surroundings of the tablet press through a non-return valve arranged to prevent outflow from the compression chamber to the surroundings of the tablet press.

Abstract: The contained module (1) comprises inlets for an active pharmaceutical ingredient (API) and for an excipient. The inlets are in fluid communication with at least one mixing unit (41,46), and the outlet of the tablet press (6) is in fluid communication with the releasable outlet port for tablets. The material stream comprising the API and the excipient is mixed in the mixing units. During operation parameters of the contents of the material stream are measured with one or more analytical sensors upstream of the tablet press. The speed of the tablet press is controlled in response to the parameters measured upstream of the tablet press. The finished tablets are discharged at an outlet of the tablet press (6).

Abstract: A continuous granulating and drying apparatus comprises a granulator and a fluid bed dryer. The fluid bed dryer comprises at least two separate processing compartments forming part of a common vessel being provided with radially extending partition walls separating the processing compartments from each other. Each processing compartment has a product inlet and a product outlet. The fluid bed dryer comprises a granulated product supply conduit arranged rotatably to selectively communicate with the product inlet of each separate processing compartment, respectively, and a product discharge conduit arranged rotatably to selectively communicate with the product outlet of each separate processing compartment, respectively. The granulator and the fluid bed dryer are closely coupled.

Abstract: A continuous granulating and drying apparatus includes a granulator and a dryer. Measurement of product and process parameters is carried out by means of measurement units positioned at critical locations in the apparatus.

Abstract: A rotary tablet press comprises a housing and a rotary die table having dies arranged circumferentially. Each die is associated with a punch having an end receivable in the die and being arranged for compression of a powder or granular material in the die by reciprocation of the punch by rotation of the die table. The rotary tablet press comprises a feeding device and a tablet discharge device. Each die opening and its corresponding punch end are enclosed in a compression chamber comprising a dust extraction nozzle. The compression chamber communicates with the surroundings of the tablet press through a non-return valve arranged to prevent outflow from the compression chamber to the surroundings of the tablet press.

Abstract: A fluid bed apparatus module (1) comprises an outer wall enclosing a processing chamber (9) and has a lower flange connection (4) and an upper flange connection (5), the lower flange connection being adapted to connection with a flange connection (14) of a supply of fluidising gas, and the upper flange connection being adapted to connection with a flange connection (17) of a filter chamber (18) for gas discharge. At least one partition element (6) is arranged in the processing chamber, so that at least one elongated channel is formed in the processing chamber, thereby defining a plug-flow area, and at least one substantially continuous product inlet (10) and at least one substantially continuous product outlet (11) are arranged in the module. Furthermore, a method comprises changing a first module for a second module in a fluid bed apparatus.

Abstract: A continuous granulating and drying apparatus comprises a granulator and a dryer. Measurement of product and process parameters is carried out by means of measurement units positioned at critical locations in the apparatus.

Abstract: A continuous granulator comprises a longitudinal granulation chamber having a first end with an inlet for powder material and a binder feed port and a second end with an outlet for granulated product. The granulation chamber comprises at least two parallel rotary shafts provided with granulating elements and forming an angle of from 0 to 70 degrees with the vertical. Each granulating element on a shaft comprises at least one lobe having limited extent in the circumferential direction of the shaft and interleaving with a lobe of a granulating element on another shaft. A plurality of such separate granulating elements are distributed from the inlet to the outlet, and successive granulating elements on a shaft are mutually angled.

Abstract: A continuous granulating and drying apparatus comprises a granulator and a fluid bed dryer. The fluid bed dryer comprises at least two separate processing compartments forming part of a common vessel being provided with radially extending partition walls separating the processing compartments from each other. Each processing compartment has a product inlet and a product outlet. The fluid bed dryer comprises a granulated product supply conduit arranged rotatably to selectively communicate with the product inlet of each separate processing compartment, respectively, and a product discharge conduit arranged rotatably to selectively communicate with the product outlet of each separate processing compartment, respectively. The granulator and the fluid bed dryer are closely coupled.

Abstract: A fluid bed apparatus module (1) comprises an outer wall enclosing a processing chamber (9) and has a lower flange connection (4) and an upper flange connection (5), the lower flange connection being adapted to connection with a flange connection (14) of a supply of fluidising gas, and the upper flange connection being adapted to connection with a flange connection (17) of a filter chamber (18) for gas discharge. At least one partition element (6) is arranged in the processing chamber, so that at least one elongated channel is formed in the processing chamber, thereby defining a plug-flow area, and at least one substantially continuous product inlet (10) and at least one substantially continuous product outlet (11) are arranged in the module. Furthermore, a method comprises changing a first module for a second module in a fluid bed apparatus.

Abstract: A rotary tablet press comprises a housing and a rotary die table having dies arranged circumferentially. Each die is associated with a punch having an end receivable in the die and being arranged for compression of a powder or granular material in the die by reciprocation of the punch by rotation of the die table. The rotary tablet press comprises a feeding device and a tablet discharge device. Each die opening and its corresponding punch end are enclosed in a compression chamber comprising a dust extraction nozzle. The compression chamber communicates with the surroundings of the tablet press through a non-return valve arranged to prevent outflow from the compression chamber to the surroundings of the tablet press.