Abstract: Disclosed is a new vector for pharmacologically active water-insoluble molecules. These nanovectors, which are in the form of carbon nanoplatforms, are capable of solubilising the active molecules while reducing the side effects of the treatments. Also disclosed are the processes for synthesizing these nanoplatforms, as well as to the use thereof as a drug, particularly in the treatment of brain tumors.

Abstract: An ionic liquid is used as liquid matrix for organic synthesis in homogeneous phase on soluble support, the ionic liquid being presented in liquid or solid form at ambient temperature, of formula A1+X1?, A1+ representing a cation, functional or non-functional, or a mixture of cations in which either none of the cations is functional or at least one of the cations is functional, and X1? an anion, functional or non-functional, or a mixture of anions in which either none of the anions is functional or at least one of the anions is functional.

Abstract: A new process for the preparation of an arylborane compound, by arylation of a B—H bond, which includes a step (1) of contacting an arenediazonium salt or a heteroarenediazonium salt with an organoboron compound containing at least one B—H bond, in a reaction medium containing a solvent, in the absence of base, in the absence or in the presence of an activating agent, for the preparation of an arylborane compound, and a possible step (2) of recovery and purification of the arylborane compound obtained at the step (1), the arylborane being in particular an aminoarylborane, and a possible step (3) of refunctionalization of the arylborane obtained at step (1) or (2) for the preparation of aryl boronic derivatives or arylborates.

Abstract: The present invention relates to a droplet microreactor, i.e. a microreactor consisting of a droplet of a specific liquid, the microreactor being wall-less, wherein the interface of the specific liquid with the ambient environment and with the support on which the droplet is deposited defines the limits of the microreactor. The microreactor is characterized in that it consists of a droplet comprising at least one ionic liquid. The present invention also relates to methods for carrying out chemical or biochemical reactions and/or mixes using said droplet microreactor, and also to a lab-on-chip comprising a microreactor according to the invention.

Abstract: Process for the synthesis of the compound of formula (I): Application in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof.

Abstract: The use of a combination of—at least one ionic liquid which is lipophilic, and non miscible with water, and—at least one enzyme, for the implementation of an esterification and/or transesterification process of a substrate with at least one alcohol, the substrate consisting of oils, fats, fatty acids, or a mixture thereof, wherein the ionic liquid, the substrate, and the alcohol form a single homogeneous liquid phase at the temperature at which the esterification and/or transesterification process is performed.

Abstract: The use of a combination of—at least one ionic liquid which is lipophilic, and non miscible with water, and—at least one enzyme, for the implementation of an esterification and/or transesterification process of a substrate with at least one alcohol, the substrate consisting of oils, fats, fatty acids, or a mixture thereof, wherein the ionic liquid, the substrate, and the alcohol form a single homogeneous liquid phase at the temperature at which the esterification and/or transesterification process is performed.

Abstract: A subject of the invention is the use of a salt with a dedicated task of formula (I): A+-L-R—OY, X? as soluble support for peptide synthesis, in which: X? represents a functional or non-functional anion, Y represents either a hydrogen atom, or a —COOR1 group, R1 representing in particular an alkyl group comprising 1 to 20 carbon atoms, A+ represents a cationic entity, L represents an arm, in particular an alkyl group of 3 to 20 carbon atoms, R represents in particular a group of formula —C(Ra)(Rb)—, Ra and Rb representing independently of one another in particular a hydrogen or an alkyl group, comprising 1 to 20 carbon atoms.

Abstract: Task-specific onium salts, process for preparing them and use thereof for detecting and assaying metals, in particular heavy metals, in an aqueous medium.

Abstract: An ionic liquid is used as liquid matrix for organic synthesis in homogeneous phase on soluble support, the ionic liquid being presented in liquid or solid form at ambient temperature, of formula A1+X1?, A1+ representing a cation, functional or non-functional, or a mixture of cations in which either none of the cations is functional or at least one of the cations is functional, and X1? an anion, functional or non-functional, or a mixture of anions in which either none of the anions is functional or at least one of the anions is functional.

Abstract: The present invention relates to a droplet microreactor, i.e. a microreactor consisting of a droplet of a specific liquid, the microreactor being wall-less, wherein the interface of the specific liquid with the ambient environment and with the support on which the droplet is deposited defines the limits of the microreactor. The microreactor is characterized in that it consists of a droplet comprising at least one ionic liquid. The present invention also relates to methods for carrying out chemical or biochemical reactions and/or mixes using said droplet microreactor, and also to a lab-on-chip comprising a microreactor according to the invention.

Abstract: The invention relates to the use of a onium salt functionalized by at least one organic function, as a soluble support, in the presence of at least one organic solvent, for organic synthesis of a molecule, in a homogenous phase, by at least one transformation of said organic function. The onium salt enables the synthesized molecule to be released. The onium salt is present in liquid or solid form at room temperature and corresponds to formula A1+, X1?, wherein A1+ represents a cation and X1? represents an anion.

Abstract: The invention concerns (aryl)(amino)borane compounds and a method for preparing same. Said compounds are of formula A-BH—NR1R2, wherein: R1 and R2 are selected among linear, branched or cyclic alkyl radicals, and arylalkyl radicals, or R1 and R2 form together an alkylene; and A represents an aromatic or heteroaromatic group optionally polycondensed, or a group selected among the vinyl, dienyl, polyenyl and alkynyl groups, all said groups optionally bearing at least one substituent. The compounds are obtained by a method which consists in preparing an amine-borane R1R2NH.BH3 complex, in transforming it into aminoborane R1R2NBH2 by heating, then in reacting it with an A-X compound wherein X is a leaving group.

Abstract: The invention relates to the use of an ionic liquid as a matrix liquid for organic synthesis in a homogeneous phase on a soluble medium, said ionic liquid being present in the form of a liquid or solid at room temperature, having formula A1+X1?, 1+ representing a functional or non-functional cation or a mixture of cations wherein none of said cations are functional or at least one of the cations is functional, and X1? a functional or non-functional anion or a mixture of anions wherein none of the anions are functional or at least one of the anions is functional.

Abstract: The invention concerns (aryl)(amino)borane compounds and a method for preparing same. Said compounds are of formula A-BH-NR1R2, wherein: R1 and R2 are selected among linear, branched or cyclic alkyl radicals, and arylalkyl radicals, or R1 and R2 form together an alkylene; and A represents an aromatic or heteroaromatic group optionally polycondensed, or a group selected among the vinyl, dienyl, polyenyl and alkynyl groups, all said groups optionally bearing at least one substituent. The compounds are obtained by a method which consists in preparing an amine-borane R1R2NH.BH3 complex, in transforming it into aminoborane R1R2NBH2 by heating, then in reacting it with an A-X compound wherein X is a leaving group.

Abstract: The present invention provides: fiber preforms sheathed in a boron nitride coating, said coating (generated on said previously-prepared fiber preforms) having a structure that is original: microporous and granular; thermostructural composite materials in which the reinforcing fabric is constituted by said fiber preforms; and methods of preparing said fiber preforms and said thermostructural composite materials, respectively. The composites of the invention have their fiber preforms, based on fibers (F), sheathed in an original interphase (IBN) and embedded in the densification matrix (M).

Abstract: Novel boron/nitrogen compounds having the formula (1): ##STR1## and the products of the at least partial reduction thereof, are converted into BN ceramic materials by thermally polymerizing same, whether or not in the presence of suitable polymerization catalyst, and then pyrolyzing the boron/nitrogen polymers thus obtained.