Patents by Inventor Michel Vivat
Michel Vivat has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5401840Abstract: Novel compounds of the formula ##STR1## wherein either K' is oxygen or a K, a protective group of the oxo of the formula ##STR2## wherein n is 2 or 3, the 17-position dotted line is a bond, R.sub.a and R.sub.b are individually selected from the group consisting of hydrogen, hydroxy, alkyl and alkoxy of 1 to 4 carbon atoms or K' is an oxygen, the 17-position dotted line is an epoxy and R.sub.a and R.sub.b have the meaning indicated above which are useful intermediates for the preparation of hydrocortisone.Type: GrantFiled: August 12, 1993Date of Patent: March 28, 1995Assignee: Roussel-UclafInventors: Francis Brion, Jean Buendia, Christian Diolez, Michel Vivat
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Patent number: 5399727Abstract: A process for the preparation of a compound of the formula ##STR1## comprising reacting a compound of the formula ##STR2## with chlorosulfonic in an organic solvent wherein the reaction is effected at -20.degree. C. to -10.degree. C. and the temperature is then allowed to rise to 0.degree. C. to 5.degree. C.Type: GrantFiled: June 2, 1993Date of Patent: March 21, 1995Assignee: Roussel-UclafInventors: Jean Buendia, Patrick Roussel, Michel Vivat
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Patent number: 5399685Abstract: A process for the preparation of a compound of the formula ##STR1## wherein R.sub.1 is alkyl of 1 to 3 carbon atoms, R.sub.2 is alkyl of 1 to 12 carbon atoms, R.sub.3 is alkyl of 1 to 4 carbon atoms comprising reacting a compound of the formula ##STR2## wherein R.sub.4 is a remainder of an easily cleavable ether, K is a protected ketone function in the form of ketal, thioketal or mixed ketal and R.sub.1 has the above definition with a magnesium organic compound reagent of the formulaHalMg--CH.sub.2 --R.sub.2 Awherein Hal is a halogen and R.sub.2 is defined as above to obtain a compound of the formula ##STR3## wherein R.sub.1, R.sub.2 and K are defined as above, reacting the latter with an acylation agent to obtain a compound of the formula ##STR4## wherein R.sub.5 is alkyl of 1 to 6 carbon atoms or aryl of 6 to 10 carbon atoms and R.sub.1, R.sub.2 and K are defined as above, reacting the latter with an appropriate alkylation agent to obtain a compound of the formula ##STR5## wherein R.sub.1, R.sub.2, R.sub.Type: GrantFiled: June 11, 1993Date of Patent: March 21, 1995Assignee: Roussel-UclafInventors: Jean Buendia, Veronique Crocq, Christian Masson, Denis Prat, Michel Vivat
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Patent number: 5352808Abstract: A process for the preparation of a compound of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms optionally substituted by halogen or a nitrogen or oxygen function and alkenyl and alkynyl of 2 to 4 carbon atoms, R.sub.2 is alkyl of 1 to 4 carbon atoms and the A, B, C and D rings are optionally substituted by at least one member of the group consisting of optionally protected --OH or .dbd.0, halogen, alkyl and alkoxy of 1 to 4 carbon atoms and alkenyl and alkynyl of 2 to 4 carbon atoms comprising reacting a compound of the formula ##STR2## wherein R.sub.1 and R.sub.2 and the A, B, C and D rings are defined as above with an oxidizing agent in the presence of water and an at least partially water-miscible solvent to obtain a compound of the formula ##STR3## wherein R.sub.1 and R.sub.Type: GrantFiled: November 5, 1992Date of Patent: October 4, 1994Assignee: Roussel UclafInventors: Jean Buendia, Michel Vivat
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Patent number: 5294704Abstract: A process for the production of a compound of the formula ##STR1## wherein R is an acyl group of 1 to 8 carbon atoms. The compound is formed through an intermediate compound of the formula ##STR2## wherein R.sub.1 is selected from the group consisting of methyl, phenyl, tolyl, and xylyl and wherein K is a protective group selected from the group consisting of ##STR3## in which n is 2 or 3 and the wavy line means that the group SO.sub.2 --R.sub.1 may have either isomeric form or are mixtures thereof.Type: GrantFiled: November 4, 1992Date of Patent: March 15, 1994Assignee: Roussel-UclafInventors: Francis Brion, Jean Buendia, Christian Diolez, Michel Vivat
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Patent number: 5260463Abstract: An improved process for the preparation of hydrocortisone and novel intermediates which avoids an 11-hydroxylation step and results in improved yields.Type: GrantFiled: August 25, 1992Date of Patent: November 9, 1993Assignee: ROUSSEL-UCLAFInventors: Francis Brion, Jean Buendia, Christian Diolez, Michel Vivat
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Patent number: 5187273Abstract: A compound of the formula ##STR1## wherein Hal is chlorine or bromine, R is selected from the group consisting of alkyl of 1 to 6 carbon atoms, aralkyl of 7 to 15 carbon atoms and a silylated group, K is a protective group selected from the group consisting of ##STR2## n is 2 or 3 and the wavy lines mean the groups may have either isomer form or are mixtures thereof which are intermediates for .DELTA..sup.4,9(11),16 -pregnatriene-3-ones.Type: GrantFiled: May 18, 1992Date of Patent: February 16, 1993Assignee: Roussel UclafInventors: Francis Brion, Jean Buendia, Christian Diolez, Michel Vivat
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Patent number: 5095130Abstract: A compound of the formula ##STR1## wherein R.sub.1 is hydrogen or methyl, R.sub.2 is methyl or ethyl, the A,B,C and D rings optionally containing at least one double bond and optionally substituted with at least one member of the group consisting of optionally protected --OH, .dbd.O, alkyl and alkoxy of 1 to 4 carbon atoms, halogen and alkenyl and alkynyl of 2 to 4 carbon atoms, R is selected from the group consisting of halogen, --OH, alkylthio and alkoxy of 1 to 6 carbon atoms, aralkoxy, arylthio and aralkylthio of 7 to 15 carbon atoms and ##STR2## R.sub.3 and R.sub.4 are individually hydrogen, or alkyl of 1 to 6 carbon atoms or aralkyl of 7 to 15 carbon atoms or taken together with the nitrogen form a heterocycle optionally containing another nitrogen or oxygen atom, excepting the product in which R is methoxy, R.sub.1 and R.sub.2 each represent methyl, A ring carries a 3.beta.-acetoxy function and B ring contains a double bond in 5(6) useful as intermediates for the preparation of 20-keto-pregnanes.Type: GrantFiled: March 5, 1990Date of Patent: March 10, 1992Assignee: Roussel UclafInventors: Michel Vivat, Jean Buendia
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Patent number: 4950428Abstract: A novel process for the preparation of 20-keto-pregnanes.Type: GrantFiled: May 25, 1989Date of Patent: August 21, 1990Assignee: Roussel UclafInventors: Michel Vivat, Jean Buendia
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Patent number: 4927921Abstract: A compound of the formula ##STR1## wherein R.sub.1 is hydrogen or methyl, R.sub.2 is methyl or ethyl, and A,B,C and D rings optionally containing at least one double bond and optionally substituted with at least one member of the group consisting of optionally protected --OH, .dbd.O, alkyl and alkoxy of 1 to 4 carbon atoms, halogen and alkenyl and alkynyl of 2 to 4 carbon atoms, R is selected from the group consisting of halogen, --OH, alkylthio and alkoxy of 1 to 6 carbon atoms, aralkoxy, arylthio and aralkylthio of 7 to 15 carbon atoms and ##STR2## R.sub.3 and R.sub.4 are individually hydrogen, or alkyl of 1 to 6 carbon atoms or aralkyl of 7 to 15 carbon atoms or taken together with the nitrogen form a heterocycle optionally containing another nitrogen or oxygen atom, excepting the product in which R is methoxy, R.sub.1 and R.sub.2 each represent methyl, A ring carries a 3.beta.-acetoxy function and B ring contains a double bond in 5(6) useful as intermediates for the preparation of 20-keto-pregnanes.Type: GrantFiled: December 4, 1987Date of Patent: May 22, 1990Assignee: Roussel UclafInventors: Michel Vivat, Jean Buendia
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Patent number: 4847014Abstract: A compound of the formula ##STR1## wherein R.sub.1 is hydrogen or methyl, R.sub.2 is methyl or ethyl, the A,B,C and D rings optionally have one or more double bonds and are optionally substituted with one or more members of the group consisting of halogen protected hydroxy, 1/8O, alkyl and alkoxy of 1 to 4 carbon atoms and alkenyl and alkynyl of 2 to 4 carbon atoms, R is selected from the group consisting of halogen, --OH, alkoxy of 1 to 6 carbon atoms, aralkoxy of 7 to 15 carbon atoms, alkylthio of 1 to 6 carbon atoms, arylthio of 6 to 14 carbon atoms, aralkylthio of 7 to 15 carbon atoms and ##STR2## wherein R.sub.3 and R.sub.4 are individually selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms and aralkyl of 7 to 15 carbon atoms or R.sub.3 and R.sub.4 together with the nitrogen atom form another heterocycle optionally containing a nitrogen atom or oxygen atom and their preparation and their use to form 20-keto-pregnanes.Type: GrantFiled: December 7, 1987Date of Patent: July 11, 1989Assignee: Roussel UclafInventors: Michel Vivat, Jean Buendia
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Patent number: 4601854Abstract: A novel process for the preparation of prednisone derivatives of the formula ##STR1## wherein R.sub.1 is alkyl of 1 to 4 carbon atoms and R.sub.Type: GrantFiled: January 28, 1985Date of Patent: July 22, 1986Assignee: Roussel UclafInventors: Jean Buendia, Michel Vivat
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Patent number: 4308209Abstract: Novel .beta.-lactones of 2-hydroxy-cyclopentane-carboxylic acids of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of hydrogen and methyl and R.sub.2 is selected from the group consisting of --CH.sub.2 --O--CH.sub.2 --CH.sub.3 and --X--Ar, X is selected from the group consisting of --O-- and --CH.sub.2 --, Ar is an optionally substituted member selected from the group consisting of thienyl, thiazolyl, phenyl and thiadiazolyl, the optional substituents being at least one member selected from the group consisting of halogen and --CF.sub.3 and the wavy lines indicate that the groups may be in the .alpha.,.beta. or .beta.,.alpha.-positions or mixtures thereof having hypotensive activity and their preparation.Type: GrantFiled: December 15, 1980Date of Patent: December 29, 1981Assignee: Roussel UclafInventors: Jean Buendia, Michel Vivat, Laurent Taliani
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Patent number: 4279919Abstract: Novel lactones of the formula ##STR1## wherein the dotted line indicates the optional presence of a second bond, A is a single bond or --CH.sub.2 --CH.sub.2 --, R is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms and alkenyl and alkynyl of 2 to 4 carbon atoms, R.sub.6 is --OR.sub.A ', R.sub.A ' is selected from the group consisting of hydrogen, tetrahydropyranyl, alkyl of 1 to 3 carbon atoms and ##STR2## R.sub.A " is selected from the group consisting of alkyl of 1 to 3 carbon atoms optionally substituted with carboxyl and phenyl optionally substituted with a member of the group consisting of carboxyl, free hydroxyl, hydroxyl protected with an acyl of 2 to 4 carbon atoms and hydroxyl protected with an easily hydrolyzable group and R and R.sub.6 together form a keto group, R.sub.7 is --CH.sub.2).sub.m.sbsb.A --CH.sub.3, m.sub.A is 3,4,5 or 6 and R.sub.6 and R.sub.7 taken together form .dbd.CH--(CH.sub.2).sub.n.sbsb.A --CH.sub.3, n.sub.Type: GrantFiled: March 17, 1980Date of Patent: July 21, 1981Assignee: Roussel UclafInventors: Jean Buendia, Michel Vivat
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Patent number: 4264623Abstract: Novel .beta.-lactones of 2-hydroxy-cyclopentane-carboxylic acids of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of hydrogen and methyl and R.sub.2 is selected from the group consisting of --CH.sub.2 --O--CH.sub.2 --CH.sub.3 and --X--Ar, X is selected from the group consisting of --O-- and --CH.sub.2 --, Ar is an optionally substituted member selected from the group consisting of thienyl, thiazolyl, phenyl and thiadiazolyl, the optional substituents being at least one member selected from the group consisting of halogen and --CF.sub.3 and thw wavy lines indicate that the groups may be in the .alpha., .beta. or .beta., .alpha.-positions or mixtures thereof having hypotensive activity and their preparation.Type: GrantFiled: November 16, 1979Date of Patent: April 28, 1981Assignee: Roussel UclafInventors: Jean Buendia, Michel Vivat, Laurent Taliani
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Patent number: 4221809Abstract: Novel lactones of the formula ##STR1## wherein the dotted line indicates the optional presence of a second bond, A is a single bond or --CH.sub.2 --CH.sub.2 --, R is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms and alkenyl and alkynyl of 2 to 4 carbon atoms, R.sub.6 is --OR'.sub.A, R'.sub.A is selected from the group consisting of hydrogen, tetrahydropyranyl, alkyl of 1 to 3 carbon atoms and ##STR2## R".sub.A is selected from the group consisting of alkyl of 1 to 3 carbon atoms optionally substituted with carboxyl and phenyl optionally substituted with a member of the group consisting of carboxyl, free hydroxyl, hydroxyl protected with an acyl of 2 to 4 carbon atoms and hydroxyl protected with an easily hydrolyzable group and R and R.sub.6 together form a keto group, R.sub.7 is --(CH.sub.2)m.sub.A --CH.sub.3, m.sub.A is 3,4,5 or 6 and R.sub.6 and R.sub.7 taken together form .dbd. CH--(CH.sub.2)n.sub. A --CH.sub.3 n.sub.Type: GrantFiled: May 8, 1979Date of Patent: September 9, 1980Assignee: Roussel UclafInventors: Jean Buendia, Michel Vivat
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Patent number: 4091226Abstract: Novel cyclopentenecarboxylates of the formula ##STR1## wherein AlK is alkyl of 1 to 4 carbon atoms and R is selected from the group consisting of --CHO and --CH.sub.Type: GrantFiled: December 2, 1976Date of Patent: May 23, 1978Assignee: Roussel UclafInventors: Jean Buendia, Michel Vivat
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Patent number: 4072755Abstract: Novel cyclopentanoic acid derivatives of the formula ##STR1## wherein R is selected from the group consisting of ##STR2## and --CH.sub.2 OH, R' is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms and a non toxic, pharmaceutically acceptable cation and R.sub.1 is selected from the group consisting of hydrogen, 2-tetrahydropyranyl, branched or straight chain, saturated or unsaturated alkyl of 1 to 4 carbon atoms and ##STR3## and R.sub.2 is selected from the group consisting of straight or branched chain alkyl of 1 to 12 carbon atoms and phenyl with the alkyl and phenyl being optionally substituted with --COOA wherein A is selected from the group consisting of hydrogen, alkali metal, ammonium ion, ion of an organic amine, alkyl and haloalkyl of 1 to 7 alkyl carbon atoms with the proviso that R.sub.1 is not hydrogen or 2-tetrahydropyranyl when R is a carboxylic group, and the OH and R groups on the ring and OR.sub.Type: GrantFiled: August 24, 1976Date of Patent: February 7, 1978Assignee: Roussel UCLAFInventors: Jean Buendia, Michel Vivat, Jeanine Schalbar
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Patent number: 4061729Abstract: Novel prostanoic acid derivatives of the formula ##STR1## wherein R is hydrogen or alkyl having 1 to 4 carbon atoms, m is a whole number from 3, 4 or 5, n is a whole number from 2, 3 or 4, R' is either a linear or branched, saturated or unsaturated aliphatic hydrocarbon having 1 to 4 carbon atoms, or a saturated or mono unsaturated cyclohydrocarbon having 3 to 6 carbon atoms and A is either alkoxy having 1 to 4 carbon atoms or oxygen of a ketonic group, the dotted lines in the pentagonal ring are possible positions of a single double bond where, when A is a ketonic oxygen, the double bond is on the exterior of the ring and when A is alkoxy, the double bond is in one of the two interior positions of the ring, as well as the pharmaceutically compatible salts of mineral or organic bases when R is hydrogen in their .alpha.,.beta. or .beta.,.alpha. forms and mixtures thereof; as well as the process for their preparation, and the therapeutic compositions containing them.Type: GrantFiled: June 17, 1975Date of Patent: December 6, 1977Assignee: Roussel UclafInventors: Jacques Martel, Jean Buendia, Michel Vivat
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Patent number: 3984442Abstract: A novel process for the preparation of substituted trans-epoxy cis-alkenes of the formula ##EQU1## wherein Alk is straight or branched alkyl of 1 to 6 carbon atoms and m is 3,4 or 5 which are intermediates for prostaglandin compounds.Type: GrantFiled: August 15, 1975Date of Patent: October 5, 1976Assignee: Roussel-UCLAFInventors: Jean Buendia, Michel Vivat