Abstract: The present disclosure relates to methods and intermediates useful for preparing a compound of formula I: or a co-crystal, solvate, salt or combination thereof.

Abstract: The present disclosure relates to methods and intermediates useful for preparing a compound of formula I: or a co-crystal, solvate, salt or combination thereof.

Abstract: The present disclosure relates to methods and intermediates useful for preparing a compound of formula I: or a co-crystal, solvate, salt or combination thereof.

Abstract: A measurement system includes: a tube; a bluff body, situated in the lumen of the tube, for generating vortices in a flowing fluid such that a Karman vortex street is formed downstream of the bluff body; a vortex sensor, having a mechanical resonant frequency, for providing a vortex sensor signal which changes over time and contains a first component representing the vortex shedding frequency and which contains a second component representing the mechanical resonant frequency of the vortex sensor; and transducer electronics for evaluating the at least one vortex sensor signal and configured to do the following: to determine vortex frequency measurement values representing the shedding frequency using the first component and, if the first component is not present, not to provide flow parameter measurement values and to generate a message indicating the current flow speed is not lower than the current acoustic velocity of the flowing fluid.

Abstract: A measurement system includes: a tube; a bluff body, situated in the lumen of the tube, for generating vortices in a flowing fluid such that a Kármán vortex street is formed downstream of the bluff body; a vortex sensor, having a mechanical resonant frequency, for providing a vortex sensor signal which changes over time and contains a first component representing the vortex shedding frequency and which contains a second component representing the mechanical resonant frequency of the vortex sensor; and transducer electronics for evaluating the at least one vortex sensor signal and configured to do the following: to determine vortex frequency measurement values representing the shedding frequency using the first component and, if the first component is not present, not to provide such flow parameter measurement values and to generate a message indicating the current flow speed is not lower than the current acoustic velocity of the flowing fluid.

Abstract: The present disclosure relates to methods and intermediates useful for preparing a compound of formula I. or a co-crystal, solvate, salt or combination thereof.

Abstract: The present disclosure relates to methods and intermediates useful for preparing a compound of formula I: or a co-crystal, solvate, salt or combination thereof.

Abstract: The present disclosure relates to methods and intermediates useful for preparing a compound of formula I: or a co-crystal, solvate, salt or combination thereof.

Abstract: Provided are influenza hemagglutinin stem domain polypeptides comprising (a) an influenza hemagglutinin HA1 domain that comprises an HA1 N-terminal stem segment comprising the amino acids from position 1 to position x, preferably from position p to position x, of the HA1 domain, covalently linked by a linking sequence of 0-50 amino acid residues to an HA1 C-terminal stem segment, comprising the amino acids from position y to and including the C-terminal amino acid of the HA1 domain; and (b) an influenza hemagglutinin HA2 domain, wherein the hemagglutinin stem domain polypeptide is resistant to protease cleavage at the junction between HA1 and HA2, and wherein one or more amino acid of the amino acids at positions 337, 340, 352, 353, 402, 406, 409, 413 and/or 416 have been mutated, as compared to the corresponding positions in wild-type influenza HA.

Abstract: The present disclosure relates to methods and intermediates useful for preparing a compound of formula I: or a co-crystal, solvate, salt or combination thereof.

Abstract: Provided herein are influenza hemagglutinin stem domain polypeptides, methods for providing hemagglutinin stem domain polypeptides, compositions comprising the same, vaccines comprising the same and methods of their use, in particular in the detection, prevention and/or treatment of influenza.

Abstract: Provided herein are influenza hemagglutinin stem domain polypeptides, methods for providing hemagglutinin stem domain polypeptides, compositions comprising the same, vaccines comprising the same and methods of their use, in particular in the detection, prevention and/or treatment of influenza

Abstract: Provided herein are multimeric influenza hemagglutinin stem domain polypeptides, methods for providing hemagglutinin stem domain polypeptides, compositions comprising the same, vaccines comprising the same and methods of their use, in particular in the detection, prevention and/or treatment of influenza.

Abstract: Provided herein are influenza hemagglutinin stem domain polypeptides, methods for providing hemagglutinin stem domain polypeptides, compositions comprising the same, vaccines comprising the same and methods of their use, in particular in the detection, prevention and/or treatment of influenza.

Abstract: A thermal, flow measuring device for ascertaining a mass flow or a flow velocity of a medium in a pipe. The thermal, flow measuring device has at least one measuring transducer with at least a first and a second sensor element. The first sensor element has a pin-shaped metal sleeve, which has a lowest point on a wall of the metal sleeve in the gravitational direction, wherein there is arranged in the metal sleeve at least one heating means, especially a heatable temperature sensor. The heating means is arranged in the metal sleeve and above the aforementioned point in the gravitational direction, in such a manner that the maximum heat input per unit area from the heating means into the medium occurs in the gravitational direction above the point.

Abstract: Provided herein are influenza hemagglutinin stem domain polypeptides, methods for providing hemagglutinin stem domain polypeptides, compositions comprising the same, vaccines comprising the same and methods of their use, in particular in the detection, prevention and/or treatment of influenza

Abstract: Provided herein are multimeric influenza hemagglutinin stem domain polypeptides, methods for providing hemagglutinin stem domain polypeptides, compositions comprising the same, vaccines comprising the same and methods of their use, in particular in the detection, prevention and/or treatment of influenza

Abstract: In a method for optimizing the pressure setting accuracy, a hydraulic pressure is built up according to a pressure requirement of a hydraulic pump, and overflow control is performed using an analog-controlling hydraulic valve and a known control characteristic curve of the analog-controlling hydraulic valve, which overflow control counteracts a pressure build-up produced by the hydraulic pump that exceeds the pressure requirement. In addition to the known control characteristic curve of the analog-controlling hydraulic valve, at least one additional valve characteristic is taken into account for the overflow control.

Abstract: Provided are influenza hemagglutinin stem domain polypeptides comprising (a) an influenza hemagglutinin HA1 domain that comprises an HA1 N-terminal stem segment comprising the amino acids from position 1 to position x, preferably from position p to position x, of the HA1 domain, covalently linked by a linking sequence of 0-50 amino acid residues to an HA1 C-terminal stem segment, comprising the amino acids from position y to and including the C-terminal amino acid of the HA1 domain; and (b) an influenza hemagglutinin HA2 domain, wherein the hemagglutinin stem domain polypeptide is resistant to protease cleavage at the junction between HA1 and HA2, and wherein one or more amino acid of the amino acids at positions 337, 340, 352, 353, 402, 406, 409, 413 and/or 416 have been mutated, as compared to the corresponding positions in wild-type influenza HA.

Abstract: A thermal, flow measuring device and method for measuring the flow of a measured medium. During a heating phase of predetermined length a constant heating current of a first electrical current source flows through a first resistor. During a first measuring phase of predetermined length a constant measurement current of a second electrical current source flows through the first resistor. During the first measuring phase a first voltage falls across the first resistor, wherein during a second measuring phase of predetermined length during the first measuring cycle the constant measurement current of the second electrical current source flows through a second resistor.