Patents by Inventor Michel Wassef
Michel Wassef has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10064948Abstract: The present invention relates to a macromolecule-loaded bioresorbable crosslinked polymer wherein the polymer is obtainable from the polymerization of: (i) at least one monomer of formula (I) (CH2?CR1)CO—K wherein: —K represents O—Z or NH—Z, Z representing (CR2R3)m—CH3, (CH2—CH2—O)m—H, (CH2—CH2—O)m—CH3, (CH2)m—NR4R5 with m representing an integer from 1 to 30; —R1, R2, R3, R4 and R5 independently represent H or a C1-C6 alkyl; and (ii) at least one bio-resorbable block copolymer cross-linker, and wherein the macromolecule is chosen in the group consisting of proteins and nucleic acids.Type: GrantFiled: March 9, 2012Date of Patent: September 4, 2018Assignees: Occlugel, Centre National de la Recherche Scientifique (CNRS), Assistance Publique Hopitaux de Paris, Universite Paris Diderot—Paris 7Inventors: Laurence Moine, Alexandre Laurent, Michel Wassef, Laurent Bedouet, Stephanie Louguet, Valentin Verret, Emeline Servais
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Patent number: 9320804Abstract: The present invention relates to a polymer obtained from the polymerization of: (i) at least one monomer of formula (I) (CH2?CR1)CO—K (I) wherein: K represents 0-Z or NH—Z, Z representing (CR2R3)m—CH3, (CH2—CH2—O)m—H, (CH2—CH2—O)m—CH3, (CH2)m—NR4R5 with m representing an integer from 1 to 30; R1, R2, R3, R4 and R5 independently represent H or a C1-C6 alkyl; and (ii) at least one bio-resorbable block copolymer cross-linker.Type: GrantFiled: September 9, 2010Date of Patent: April 26, 2016Assignees: OCCLUGEL, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE PARIS-SUD 11, ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS, UNIVERSITE PARIS DIDEROT PARIS 7Inventors: Laurence Moine, Laurent Bedouet, Alexandre Laurent, Denis Labarre, Michel Wassef, Van Nga Nguyen
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Patent number: 9320806Abstract: The present invention relates to a polymer obtained from the polymerization of: (i) at least one monomer of formula (I) (CH2?CR1)CO—K (1) wherein: —K represents O—Z or N H—Z, Z representing (CR2R3)m-CH3, (CH2—CH2—O)m-H, (CH2—CH2—O)m-CH3, (CH2)m-NR4R5 with m representing an integer from 1 to 30; —R1, R2, R3, R4 and R5 independently represent H or a C1-C6 alkyl; (ii) at least between 0.1 and 50% mol, advantageously between 1 and 30% mol, more advantageously between 1 and 20 mol % of a cyclic monomer having a exomethylene group of formula (II) wherein: — R6, R7, R8 and R9 represent independently H or a C5-C7 aryl group or R6 and R9 are absent and R7 and R8 form together with the carbon atom on which they are bonded a C5-C7 aryl group; —i and j represent independently an integer chosen between 0 and 2; —X represents either O or X is not present and in this latter case, CR6R7 and CR8R9 are linked via a single bond C—C and (iii) at least one bio-resorbable block copolymer cross-linker.Type: GrantFiled: March 9, 2012Date of Patent: April 26, 2016Assignees: Occlugel, Centre National De La Recherche Scientifique, Assistance Publique-Hopitaux De Paris, Universite Paris Diderot-ParisInventors: Laurence Moine, Alexandre Laurent, Michel Wassef, Laurent Bedouet, Stephanie Louguet, Valentin Verret, Emeline Servais
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Patent number: 8673264Abstract: An injectable biomaterial containing a non-aqueous solvent suitable for injection to a human being and nanoparticles made of a polymer that is insoluble in water and insoluble in the non-aqueous solvent, in which the nanoparticles are loaded with a drug or a biological agent. The injectable biomaterial is suitable for occluding normal or malformative blood vessels or non-circulating cavities, or for necrosing tumors.Type: GrantFiled: March 2, 2010Date of Patent: March 18, 2014Assignee: Assistance Publique-Hopitaux de ParisInventors: Minh Tam Baylatry, Anouk Bisdorf-Bresson, Denis Labarre, Alexandre Laurent, Laurence Moine, Jean-Pierre Saint-Maurice, Khelil Slimani, Michel Wassef
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Publication number: 20130344160Abstract: The present invention relates to a macromolecule-loaded bioresorbable crosslinked polymer wherein the polymer is obtainable from the polymerization of: (i) at least one monomer of formula (I) (CH2?CR1)CO—K wherein: —K represents O-Z or NH-Z, Z representing (CR2R3)m—CH3, (CH2—CH2—O)m—H, (CH2—CH2—O)m—CH3, (CH2)m—NR4R5 with m representing an integer from 1 to 30; —R1, R2, R3, R4 and R5 independently represent H or a C1-C6 alkyl; and (ii) at least one bio-resorbable block copolymer cross-linker, and wherein the macromolecule is chosen in the group consisting of proteins and nucleic acids.Type: ApplicationFiled: March 9, 2012Publication date: December 26, 2013Applicants: OCCLUGEL, UNIVERSITE PARIS DIDEROT - PARIS 7, ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Laurence Moine, Alexandre Laurent, Michel Wassef, Laurent Bedouet, Stephanie Louguet, Valentin Verret, Emeline Servais
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Publication number: 20130344159Abstract: The present invention relates to a polymer obtained from the polymerization of: (i) at least one monomer of formula (I) (CH2?CR1)CO—K (1) wherein: K represents O—Z or NH—Z, Z representing (CR2R3)m-CH3, (CH2—CH2—O)m-H, (CH2—CH2—O)m-CH3, (CH2)m-NR4R5 with m representing an integer from 1 to 30; R1, R2, R3, R4 and R5 independently represent H or a C1-C6 alkyl; (ii) at least between 0.1 and 50% mol, advantageously between 1 and 30% mol, more advantageously between 1 and 20 mol % of a cyclic monomer having a exomethylene group of formula (II) wherein: R6, R7, R8 and R9 represent independently H or a C5-C7 aryl group or R6 and R9 are absent and R7 and R8 form together with the carbon atom on which they are bonded a C5-C7 aryl group; i and j represent independently an integer chosen between 0 and 2; X represents either O or X is not present and in this latter case, CR6R7 and CR8R9 are linked via a single bond C—C and (iii) at least one bio-resorbable block copolymer cross-linker.Type: ApplicationFiled: March 9, 2012Publication date: December 26, 2013Applicants: OCCLUGEL, UNIVERSITE PARIS DIDEROT - PARIS 7, ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Laurence Moine, Alexandre Laurent, Michel Wassef, Laurent Bedouet, Stephanie Louguet, Valentin Verret, Emeline Servais
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Publication number: 20120230937Abstract: The present invention relates to a polymer obtained from the polymerization of: (i) at least one monomer of formula (I) (CH2?CR1)CO—K (I) wherein: K represents 0-Z or NH—Z, Z representing (CR2R3)m—CH3, (CH2—CH2—O)m—H, (CH2—CH2—O)m—CH3, (CH2)m—NR4R5 with m representing an integer from 1 to 30; R1, R2, R3, R4 and R5 independently represent H or a C1-C6 alkyl; and (ii) at least one bio-resorbable block copolymer cross-linker.Type: ApplicationFiled: September 9, 2010Publication date: September 13, 2012Applicants: OCCLUGEL, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE PARIS DIDEROT PARIS 7, ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS, UNIVERSITE PARIS-SUD 11Inventors: Laurence Moine, Laurent Bedouet, Alexandre Laurent, Denis Labarre, Michel Wassef, Van Nga Nguyen
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Publication number: 20120195826Abstract: The invention relates to an injectable biomaterial. The injectable biomaterial of the invention comprises a non aqueous solvent which is compatible for injection to human being and nanoparticles made of a polymer which is insoluble in water and insoluble in said non aqueous solvent, said nanoparticles being loaded with a drug or a biological agent. The injectable biomaterial of the invention is particularly appropriate for occluding normal or malformative blood vessels or non circulating cavities or for necrosing tumors.Type: ApplicationFiled: March 2, 2010Publication date: August 2, 2012Applicant: ASSISTANCE PUBLIQUE - HOPITAUX DE PARISInventors: Minh Tam Baylatry, Anouk Bisdorf-Bresson, Denis Labarre, Alexandre Laurent, Laurence Moine, Jean-Pierre Saint-Maurice, Khelil Slimani, Michel Wassef
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Publication number: 20060210635Abstract: The invention relates to injectable gel-forming compositions which contain an association of linear and cross-linked polymers and are embodied in the form of a suspension. The use of said compositions, in particular for filling pipes and cavities is also disclosed.Type: ApplicationFiled: January 5, 2004Publication date: September 21, 2006Applicants: ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS, UNIVERSITE PARIS SUD XIInventors: Alexandre Laurent, Denis Labarre, Jiri Labsky, Jiri Honiger, Rene Chapot, Michel Wassef, Aymeric Seron
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Microspheres useful for therapeutic vascular occlusions and injectable solutions containing the same
Patent number: 5648100Abstract: The present invention concerns the use of microspheres for therapeutic embolization consisting of a hydrophilic acrylic copolymer coated with a cell adhesion promoter.Type: GrantFiled: June 6, 1995Date of Patent: July 15, 1997Assignees: Assistance Publique Hopitaux de Paris, BioSepra S.A.Inventors: Egisto Boschetti, Michel Brouard, Ludovic Drouet, Pierre Girot, Alexandre Laurent, Michel Wassef -
Microspheres useful for therapeutic vascular occlusions and injectable solutions containing the same
Patent number: 5635215Abstract: The present invention concerns the use of microspheres for therapeutic embolization consisting of a hydrophilic acrylic copolymer coated with a cell adhesion promoter.Type: GrantFiled: March 29, 1994Date of Patent: June 3, 1997Assignees: BioSepra S.A., Assistance Publique Hopitaux de ParisInventors: Egisto Boschetti, Michel Brouard, Ludovic Drouet, Pierre Girot, Alexandre Laurent, Michel Wassef