Patents by Inventor Michel Wierzbicki

Michel Wierzbicki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5492913
    Abstract: The compounds are N-(unsubstituted or substituted) N'-benzylpiperazine compounds and pharmaceutically tolerable salts thereof, useful for treating neuronal disorders resulting from the dysfunctioning of oxidative metabolism.A compound disclosed is: N-ethyl N'-(2-hydroxy-3,4- dimethoxybenzyl)-piperazine and its dihydrochloride.
    Type: Grant
    Filed: March 23, 1994
    Date of Patent: February 20, 1996
    Assignee: Adir et Compagnie
    Inventors: Michel Wierzbicki, Jean Lepagnol, Jean-Paul Tillement, Bernard Testa, Yves Rolland
  • Patent number: 5266718
    Abstract: New ethanolamine benzoate compounds which can be used as medicaments and correspond to the formula: ##STR1## wherein R is as defined in the description, in the form of racemic compounds and enantiomers. These new compounds and their physiologically tolerable salts can be used therapeutically for treatment of insulin-resistance states.
    Type: Grant
    Filed: June 12, 1992
    Date of Patent: November 30, 1993
    Assignee: Adir et Compagnie
    Inventors: Michel Wierzbicki, Pierre Hugon, Jacques Duhault, Francoise Lacour, Michelle Boulanger
  • Patent number: 5266591
    Abstract: The compounds are ethanolamine benzoate compounds useful for the treatment of syndrome X, and of hypertension in patients who are insulin resistant or have one or more metabolic anomalies.A compound disclosed is S-1-(m-trifluoromethylphenyl)-2-{.beta.-{4-[2-(N-(3,3-diphenylpropionyl)am ino)ethyl] benzoyloxy}ethylamino} propane.
    Type: Grant
    Filed: November 20, 1992
    Date of Patent: November 30, 1993
    Assignee: Adir et Compagnie
    Inventors: Michel Wierzbicki, Pierre Hugon, Jacques Duhault, Michelle Boulanger, Francoise Lacour
  • Patent number: 5175294
    Abstract: New thiophene compounds of the formula: ##STR1## in which: X represents hydrogen, halogen, C.sub.1 -C.sub.5 alkyl or alkoxy or dialkylamino;n represents 1 or 2;a represents an integer of from 2 to 6;b represents 2 or 3;c represents 1 or 2, and is such that b+c=4;R.sub.1 and R.sub.2 represent hydrogen or (C.sub.1 -C.sub.5)alkyl, or together with the carbon atom to which they are bonded form a hydrocarbon ring containing from 3 to 6 carbon atoms; andR and R' represent hydrogen or (C.sub.1 -C.sub.5)alkyl, or together with the nitrogen atom to which they are bonded form a pentagonal or hexagonal heterocycle optionally containing an oxygen atom or a second nitrogen atom which may itself be substituted; and their physiologically tolerable salts.The products of the invention can be used therapeutically especially in the treatment of pathologies that are characterized by a loss of bone tissue.
    Type: Grant
    Filed: August 5, 1991
    Date of Patent: December 29, 1992
    Assignee: Adir et Compagnie
    Inventors: Michel Wierzbicki, Frederic Sauveur, Jacqueline Bonnet, Martine Brisset, Charles Tordjman
  • Patent number: 5128367
    Abstract: New divalent metal salts of 2-[N,N-di(carboxymethyl)amino]-3-cyano-4-carboxymethylthiophene-5-carboxyl ic acid, which can be used therapeutically especially in the treatment of bone diseases, cutaneous and vascular ageing, hepatic diseases and dental diseases.
    Type: Grant
    Filed: August 31, 1990
    Date of Patent: July 7, 1992
    Assignee: Adir et Compagnie
    Inventors: Michel Wierzbicki, Jacqueline Bonnet, Martine Brisset, Yannis Tsouderos
  • Patent number: 5079245
    Abstract: The compounds 2-trifluoromethyl-7-substituted-6,7,8,9-tetrahydro-[5H]-benzocycloheptenes are disclosed and disclosed to be useful in the treatment of metabolic illnesses such as diabetes, obesity, and their complications. A perferred compound is 2-trifluoromethyl-7-amino-6,7,8,9-tetrahydro-[5H-benzocycloheptane.
    Type: Grant
    Filed: July 5, 1989
    Date of Patent: January 7, 1992
    Assignee: Adir et Compagnie
    Inventors: Michel Wierzbicki, Pierre Hugon, Jacques Duhault, Francoise Lacour
  • Patent number: 5061704
    Abstract: 1. New thiophene compounds of the formula: ##STR1## in which: X represents hydrogen, halogen, C.sub.1 -C.sub.5 alkyl or alkoxy or dialkylamino;n represents 1 or 2;a represents an integer of from 2 to 6;b represents 2 or 3;c represents 1 or 2, and is such that b+c=4;R.sub.1 and R.sub.2 represent hydrogen or (C.sub.1 -C.sub.5)alkyl, or together with the carbon atom to which they are bonded form a hydrocarbon ring containing from 3 to 6 carbon atoms; andR and R' represent hydrogen or (C.sub.1 -C.sub.5)alkyl, or together with the nitrogen atom to which they are bonded form a pentagonal or hexagonal heterocycle optionally containing an oxygen atom or a second nitrogen atom which may itself be substituted; and their physiologically tolerable salts.The products of the invention can be used therapeutically especially in the treatment of pathologies that are characterized by a loss of bone tissue.2.
    Type: Grant
    Filed: November 23, 1990
    Date of Patent: October 29, 1991
    Assignee: Adir et Compagnie
    Inventors: Michel Wierzbicki, Frederic Sauveur, Jacqueline Bonnet, Martine Brisset, Charles Tordjman
  • Patent number: 4939164
    Abstract: New distrontium salt of 3-(1-carboxymethyl-2-carboxy-pyrrol-4-yl)-pentanedioic acid which can be used therapeutically especially in the treatment of osseous diseases.
    Type: Grant
    Filed: June 20, 1989
    Date of Patent: July 3, 1990
    Assignee: Adir et Compagnie
    Inventors: Michel Wierzbicki, Jacqueline Bonnet, Yannis Tsouderos
  • Patent number: 4711885
    Abstract: Triazole compounds of the formula: ##STR1## in which: X and X', which are the same or different, each represents hydrogen, halogen, trifluoromethyl, C.sub.1 -.sub.5 alkyl, or C.sub.1 -.sub.5 alkoxy, orX and X' together represent methylenedioxy,n is an integer of from 1 to 6,a is 0, 1 or 2;b is 0, 1, 2 or 3;c is 0, 1 or 2 andd is 2, 3, 4 or 5 such that a+b+c+d is equal to 4, 5, 6 or 7.These compounds and physiologically tolerable acid addition salts thereof may be used as medicines especially in the treatment of pain and anxiety.
    Type: Grant
    Filed: April 1, 1986
    Date of Patent: December 8, 1987
    Assignee: Adir et Compagnie
    Inventors: Michel Wierzbicki, Pierre Hugon, Jean-Claude Poignant
  • Patent number: 4608384
    Abstract: New thieno[2,3-b] pyrrole compounds of the formula: ##STR1## in which: R.sub.1 is hydrogen or lower alkyl,R.sub.2 is cyano, carboxy, COOM in which M is alkali alkaline-earth metal, ammonium mono-, di-, or tri-, (C.sub.1 -C.sub.5) alkylammonium optionally substituted by hydroxy, COOR in which R is lower alkyl, or ##STR2## in which R' and R" are hydrogen or lower alkyl; R.sub.3 is lower alkyl; andR.sub.4 is lower alkyl, phenyl, halophenyl, lower alkylphenyl, lower alkoxy-phenyl nitrophenyl and di-lower-alkylamino,and enatiomers thereof.These new compounds may be used as medicines especially in the treatment of acute and chronic pains.
    Type: Grant
    Filed: December 12, 1983
    Date of Patent: August 26, 1986
    Assignee: Adir, S.A.R.L.
    Inventors: Michel Wierzbicki, Jacques Bure
  • Patent number: 4567196
    Abstract: New thieno [2,3-b] pyrrole compounds of the formula: ##STR1## in which: R is hydrogen, (C.sub.1 -C.sub.5) alkyl, alkali or alkaline earth metals ammnonium or mono- di- or tri-(C.sub.1 -C.sub.5) alkylammnonium;R.sub.1 is hydrogen, or (C.sub.1 -C.sub.5) alkyl;R.sub.2 is hydrogen, (C.sub.1 -C.sub.5) alkyl, phenyl or phenyl-(C.sub.1 -C.sub.5) alkyl;R.sub.3 and R.sub.4, the same or different are each hydrogen, halogen, (C.sub.1 -C.sub.5) alkyl, (C.sub.1 -C.sub.5) alkoxy, orR.sub.3 and R.sub.4 together represent: --CH.dbd.CH--CH.dbd.CH--.These new compounds may be used as medicines especially in the treatment of acute or chronic pain.
    Type: Grant
    Filed: November 2, 1984
    Date of Patent: January 28, 1986
    Assignee: ADIR, s.a.r.l.
    Inventor: Michel Wierzbicki