Patents by Inventor Michelangelo Scalone

Michelangelo Scalone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NITROGEN CONTAINING BIOPOLYMER-BASED CATALYSTS, A PROCESS FOR THEIR PREPARATION AND USES THEREOF
    Publication number: 20220297096
    Abstract: The present invention relates to a novel process for the preparation of a nitrogen containing biopolymer-based catalyst and to the novel nitrogen containing biopolymer-based catalysts obtainable by this process. In particular, the invention relates to a novel nitrogen containing biopolymer-based catalyst comprising metal particles and at least one nitrogen containing carbon layer. The invention also relates to the use of a nitrogen containing biopolymer-based catalyst in a hydrogenation process, preferably in a process for hydrogenation of nitroarenes, nitriles or imines; in a reductive dehalogenation process of C—X bonds, wherein X is Cl, Br or I, preferably in a process for dehalogenation of organohalides or in a process for deuterium labelling of arenes via dehalogenation of organohalides; or in an oxidation process.
    Type: Application
    Filed: March 23, 2022
    Publication date: September 22, 2022
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Stephan BACHMANN, Matthias BELLER, Dario FORMENTI, Kathrin JUNGE, Basudev SAHOO, Michelangelo SCALONE, Christoph TOFP
  • Chiral metal complex compounds
    Patent number: 11124532
    Abstract: The invention comprises novel chiral metal complex compounds of the formula wherein M, PR2, R3 and R4 are outlined in the description, its stereoisomers, in the form as a neutral complex or a complex cation with a suitable counter ion. The chiral metal complex compounds can be used in asymmetric reactions, particularly in asymmetric reductions of ketones, imines or oximes.
    Type: Grant
    Filed: October 10, 2019
    Date of Patent: September 21, 2021
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Stephan Bachmann, Matthias Beller, Marcel Garbe, Kathrin Junge, Michelangelo Scalone
  • Processes for the preparation of pyrimidinylcyclopentane compounds
    Patent number: 10858324
    Abstract: The present invention relates to a process for the preparation of a compound of formula (I) wherein R1 is as defined herein, which is useful as an intermediate in the preparation of active pharmaceutical compounds.
    Type: Grant
    Filed: August 29, 2019
    Date of Patent: December 8, 2020
    Assignee: GENENTECH, INC.
    Inventors: Hans Iding, Reinhard Reents, Michelangelo Scalone, Francis Gosselin
  • PROCESSES FOR THE PREPARATION OF PYRIMIDINYLCYCLOPENTANE COMPOUNDS
    Publication number: 20200062717
    Abstract: The present invention relates to a process for the preparation of a compound of formula (I) wherein R1 is as defined herein, which is useful as an intermediate in the preparation of active pharmaceutical compounds.
    Type: Application
    Filed: August 29, 2019
    Publication date: February 27, 2020
    Applicant: GENENTECH, INC.
    Inventors: Hans Iding, Reinhard Reents, Michelangelo Scalone, Francis Gosselin
  • CHIRAL METAL COMPLEX COMPOUNDS
    Publication number: 20200040021
    Abstract: The invention comprises novel chiral metal complex compounds of the formula wherein M, PR2, R3 and R4 are outlined in the description, its stereoisomers, in the form as a neutral complex or a complex cation with a suitable counter ion. The chiral metal complex compounds can be used in asymmetric reactions, particularly in asymmetric reductions of ketones, imines or oximes.
    Type: Application
    Filed: October 10, 2019
    Publication date: February 6, 2020
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Stephan Bachmann, Matthias Beller, Marcel Garbe, Kathrin Junge, Michelangelo Scalone
  • NITROGEN CONTAINING BIOPOLYMER-BASED CATALYSTS, A PROCESS FOR THEIR PREPARATION AND USES THEREOF
    Publication number: 20190381485
    Abstract: The present invention relates to a novel process for the preparation of a nitrogen containing biopolymer-based catalyst and to the novel nitrogen containing biopolymer-based catalysts obtainable by this process. In particular, the invention relates to a novel nitrogen containing biopolymer-based catalyst comprising metal particles and at least one nitrogen containing carbon layer. The invention also relates to the use of a nitrogen containing biopolymer-based catalyst in a hydrogenation process, preferably in a process for hydrogenation of nitroarenes, nitriles or imines; in a reductive dehalogenation process of C—X bonds, wherein X is Cl, Br or I, preferably in a process for dehalogenation of organohalides or in a process for deuterium labelling of arenes via dehalogenation of organohalides; or in an oxidation process.
    Type: Application
    Filed: June 19, 2019
    Publication date: December 19, 2019
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Stephen Bachmann, Matthias Beller, Dario Formenti, Kathrin Junge, Basudev Sahoo, Michelangelo Scalone, Christoph Topf
  • Processes for the preparation of pyrimidinylcyclopentane compounds
    Patent number: 10435378
    Abstract: The present invention relates to a process for the preparation of a compound of formula (I) wherein R1 is as defined herein, which is useful as an intermediate in the preparation of active pharmaceutical compounds.
    Type: Grant
    Filed: November 30, 2017
    Date of Patent: October 8, 2019
    Assignee: GENENTECH, INC.
    Inventors: Hans Iding, Reinhard Reents, Michelangelo Scalone, Francis Gosselin
  • Process for preparing a compound
    Patent number: 10329288
    Abstract: The invention provides processes of preparation thereof useful in the preparation of compounds that can be used as CHK1 inhibitors.
    Type: Grant
    Filed: August 21, 2014
    Date of Patent: June 25, 2019
    Assignees: Genentech, Inc., Array BioPharma Inc.
    Inventors: Chong Han, Keena Green, Francis Gosselin, Michelangelo Scalone, Paul J. Nichols, Weidong Liu, Keith L. Spencer, Zackary D. Crane, Peter J. Stengel, Sagar Shakya
  • PROCESS FOR THE PREPARATION OF PROPIONIC ACID DERIVATIVES
    Publication number: 20190106416
    Abstract: The invention relates to a process for the preparation of a compound of formula (I) or a salt thereof.
    Type: Application
    Filed: December 11, 2018
    Publication date: April 11, 2019
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Kurt Puentener, Michelangelo Scalone
  • PROCESSES FOR THE PREPARATION OF PYRIMIDINYLCYCLOPENTANE COMPOUNDS
    Publication number: 20180086722
    Abstract: The present invention relates to a process for the preparation of a compound of formula (I) wherein R1 is as defined herein, which is useful as an intermediate in the preparation of active pharmaceutical compounds.
    Type: Application
    Filed: November 30, 2017
    Publication date: March 29, 2018
    Applicant: GENENTECH, INC.
    Inventors: Hans Iding, Reinhard Reents, Michelangelo Scalone, Francis Gosselin
  • Processes for the preparation of pyrimidinylcyclopentane compounds
    Patent number: 9862689
    Abstract: The present invention relates to a process for the preparation of a compound of formula (I), wherein R1 is as defined herein, which is useful as an intermediate in the preparation of active pharmaceutical compounds.
    Type: Grant
    Filed: November 13, 2014
    Date of Patent: January 9, 2018
    Assignee: GENENTECH, INC.
    Inventors: Hans Iding, Reinhard Reents, Michelangelo Scalone, Francis Gosselin
  • Process
    Patent number: 9603816
    Abstract: The present invention relates to a process for the preparation of S-[2-[1-(2 -ethylbutyl)cyclohexylcarbonylamino]-phenyl] 2-methylthiopropionate which is useful as a pharmaceutically active compound.
    Type: Grant
    Filed: December 18, 2013
    Date of Patent: March 28, 2017
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Hans-Juergen Mair, Reinhard Reents, Michelangelo Scalone, Shaoning Wang, Andreas Zogg
  • Process to manufacture N-[(3S)-1-[4-[(3-fluorophenyl)methoxy]phenyl]-5-oxo-pyrrolidin-3-yl]acetamide
    Patent number: 9562009
    Abstract: The present invention provides processes to manufacture crystalline N-[(3S)-1-[4-[(3-fluorophenyl)methoxy]phenyl]-5-oxo-pyrrolidin-3-yl]acetamide. Also disclosed are compounds useful as intermediates in the methods of the invention.
    Type: Grant
    Filed: April 27, 2016
    Date of Patent: February 7, 2017
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Olaf Grassmann, Stefan Hildbrand, Roland Meier, Michelangelo Scalone, Urs Schwitter, Beat Wirz, Ulrich Zutter
  • PROCESSES FOR THE PREPARATION OF PYRIMIDINYLCYCLOPENTANE COMPOUNDS
    Publication number: 20160297773
    Abstract: The present invention relates to a process for the preparation of a compound of formula (I), wherein R1 is as defined herein, which is useful as an intermediate in the preparation of active pharmaceutical compounds.
    Type: Application
    Filed: November 13, 2014
    Publication date: October 13, 2016
    Applicant: GENENTECH, INC.
    Inventors: Hans IDING, Reinhard REENTS, Michelangelo SCALONE, Francis GOSSELIN
  • PROCESS TO MANUFACTURE N-[(3S)-1-[4-[(3-FLUOROPHENYL)METHOXY]PHENYL]-5-OXO-PYRROLIDIN-3-YL]ACETAMIDE
    Publication number: 20160237032
    Abstract: The present invention provides processes to manufacture crystalline N-[(3S)-1-[4-[(3-fluorophenyl)methoxy]phenyl]-5-oxo-pyrrolidin-3-yl]acetamide. Also disclosed are compounds useful as intermediates in the methods of the invention.
    Type: Application
    Filed: April 27, 2016
    Publication date: August 18, 2016
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Olaf Grassmann, Stefan Hildbrand, Roland Meier, Michelangelo Scalone, Urs Schwitter, Beat Wirz, Ulrich Zutter
  • PROCESS FOR PREPARING A COMPOUND
    Publication number: 20160200723
    Abstract: The invention provides processes of preparation thereof useful in the preparation of compounds that can be used as CHK1 inhibitors.
    Type: Application
    Filed: August 21, 2014
    Publication date: July 14, 2016
    Applicants: Genentech, Inc., Array BioPharma Inc.
    Inventors: Chong HAN, Keena GREEN, Francis GOSSELIN, Michelangelo SCALONE, Paul J. NICHOLS, Weidong LIU, Keith L. SPENCER, Zackary D. CRANE, Peter J. STENGEL, Sagar SHAKYA
  • Bicyclic dihydroquinoline-2-one derivatives
    Patent number: 9353081
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, A1, A2 A3 and n are as described herein, compositions including the compounds and methods of using the compounds. The compounds of the present invention are useful as inhibitors of aldosterone synthase. The compounds may be used, for example, in the treatment or prophylaxis of chronic kidney disease, congestive heart failure, hypertension, primary aldosteronism and Cushing syndrome.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: May 31, 2016
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Johannes Aebi, Kurt Amrein, Serena Maria Fantasia, Benoit Hornsperger, Bernd Kuhn, Yongfu Liu, Hans P. Maerki, Alexander V. Mayweg, Peter Mohr, Michelangelo Scalone, Xuefei Tan, Mingwei Zhou
  • SYNTHESIS OF BACE INHIBITORS
    Publication number: 20160090360
    Abstract: The present invention provides a one step carbonylation of a compound of formula II in the presence of water to afford a compound of formula (I), useful in processes to manufacture BACE inhibitors.
    Type: Application
    Filed: April 23, 2014
    Publication date: March 31, 2016
    Inventors: Alec Fettes, Hans-Peter Marty, Michelangelo Scalone
  • Process for the preparation of cyclohexanecarboxylic acid derivatives
    Patent number: 8975438
    Abstract: A process for the preparation of a compound of formula (I): which is useful as an intermediate in the preparation of pharmaceutically active compounds.
    Type: Grant
    Filed: July 5, 2012
    Date of Patent: March 10, 2015
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Beat Birrer, Leo Clarke, Walter Deichtmann, John Hayes, Julius Jeisy, Christian Lautz, Rainer E. Martin, Michael Meade, Joaquim Pintao, Michelangelo Scalone, Juergen Schaefer, Dennis Smith, Andreas Staempfli, Joachim Veits, Christian Walch, Andrew Walsh, Andreas Zogg
  • PROCESS FOR THE PREPARATION OF PYRIDO[2,1-a] ISOQUINOLINE DERIVATIVES BY CATALYTIC ASYMMETRIC HYDROGENATION OF AN ENAMINE
    Publication number: 20150031888
    Abstract: The invention relates to a process for the preparation of pyrido[2,1-a] isoquinoline derivatives of the formula wherein R2, R3 and R4 are as defined in the specification, comprising the steps of a) catalytic asymmetric hydrogenation of an enamine of the formula wherein R1 is lower alkyl, in the presence of a transition metal catalyst containing a chiral diphosphane ligand, b) introduction of an amino protecting group Prot and c) amidation of the ester to form an amide of formula wherein R2, R3, R4 and Prot are as defined in the specification.
    Type: Application
    Filed: October 3, 2014
    Publication date: January 29, 2015
    Inventors: Stefan Abrecht, Michelangelo Scalone, Rudolf Schmid