Patents by Inventor Michele Barone

Michele Barone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9347953
    Abstract: The present invention relates to a method for diagnosing a carcinoma or a residual disease associated thereto, or for the prognosis of a carcinoma, or for monitoring the effectiveness of an anti-tumour therapy directed against a carcinoma, or for monitoring the follow-up of an individual affected by a carcinoma, in particular colorectal carcinoma, carcinoma of the stomach, mammary carcinoma, pulmonary carcinoma or carcinoma of the prostate, carcinoma of the liver, carcinoma of the ovary, carcinoma of the kidney, carcinoma of the thyroid, carcinoma of the bladder or carcinoma of the pancreas. The method of the invention consists in placing adult stem cells in contact with a sample of a haemo-derivative of the individual to be analyzed and in verifying the expression of at least an epithelial marker in the stem cells by means of immunofluorescence, immunohistochemistry, ELISA or RT-PCR.
    Type: Grant
    Filed: December 6, 2010
    Date of Patent: May 24, 2016
    Assignee: THD S.p.A.
    Inventors: Filippo Bastia, Donato Altomare, Alfredo Di Leo, Maria Teresa Rotelli, Michele Barone
  • Publication number: 20130316361
    Abstract: The present invention relates to a method for diagnosing a carcinoma or a residual disease associated thereto, or for the prognosis of a carcinoma, or for monitoring the effectiveness of an anti-tumour therapy directed against a carcinoma, or for monitoring the follow-up of an individual affected by a carcinoma, in particular colorectal carcinoma, carcinoma of the stomach, mammary carcinoma, pulmonary carcinoma or carcinoma of the prostate, carcinoma of the liver, carcinoma of the ovary, carcinoma of the kidney, carcinoma of the thyroid, carcinoma of the bladder or carcinoma of the pancreas. The method of the invention consists in placing adult stem cells in contact with a sample of a haemo-derivative of the individual to be analysed and in verifying the expression of at least an epithelial marker in the stem cells by means of immunofluorescence, immunohistochemistry, ELISA or RT-PCR.
    Type: Application
    Filed: December 6, 2010
    Publication date: November 28, 2013
    Applicant: THD S.P.A.
    Inventors: Filippo Bastia, Donato Altomare, Alfredo Di Leo, Maria Teresa Rotelli, Michele Barone
  • Publication number: 20110027230
    Abstract: Oral compositions comprising an association of one or of a mixture of phytoestrogens, selective for the estrogen receptor-?, with dietary fibres are described. The compositions thereof can be profitably used for the prophylactic and therapeutic treatment in mammals, including humans, of health conditions characterised by a high risk of onset and recurrence of intestinal adenomas (adenopolyposis coli), and of adenoma's progression to colorectal carcinoma. In presence of pre-cancerous lesions in the colon, characterised by mutations of the APC tumor suppressor and defined as polyps or adenomas, the oral compositions disclosed can be in fact profitably used to reduce the number and volume of polyps, and to prevent their progression to neoplastic transformation, reducing their degree of dysplasia.
    Type: Application
    Filed: February 20, 2009
    Publication date: February 3, 2011
    Inventors: Alfredo Di Leo, Michele Barone
  • Patent number: 6695134
    Abstract: A joint for toothed belt aimed at conveying articles, with the belt including an inner central layer, which defines the belt body, an upper layer, which defines a surface for receiving articles to be conveyed, and a lower layer featuring teeth, includes: first connecting mechanism, attached in an irremovable way to the central layer in the area of the terminal section of a belt first edge to be joined; second connecting mechanism, attached irremovably to the central layer in the area of the terminal section of a belt second edge to be joined. After the first edge had been moved close to the second edge to complete a closed loop formed by the belt, the first connecting mechanism and second connecting mechanism engage with each other and are reciprocally locked in a removable way by locking mechanism, acting crosswise to the belt in the area of the central layer, to join the first edge and second edge.
    Type: Grant
    Filed: February 3, 2003
    Date of Patent: February 24, 2004
    Assignee: Vision Tech S.r.l.
    Inventors: Carmen Rubino, Attilio Rubino, Michele Barone, Damiano Dondarini, Marco Verri
  • Publication number: 20030146072
    Abstract: A joint for toothed belt aimed at conveying articles, with the belt including an inner central layer, which defines the belt body, an upper layer, which defines a surface for receiving articles to be conveyed, and a lower layer featuring teeth, includes: first connecting means, attached in an irremovable way to the central layer in the area of the terminal section of a belt first edge to be joined; second connecting means, attached irremovably to the central layer in the area of the terminal section of a belt second edge to be joined. After the first edge had been moved close to the second edge to complete a closed loop formed by the belt, the first connecting means and second connecting means engage with each other and are reciprocally locked in a removable way by locking means, acting crosswise to the belt in the area of the central layer, to join the first edge and second edge.
    Type: Application
    Filed: February 3, 2003
    Publication date: August 7, 2003
    Inventors: Carmen Rubino, Attilio Rubino, Michele Barone, Damiano Dondarini, Marco Verri