Patents by Inventor Michele Benotti

Michele Benotti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis of cephalosporin compounds
    Patent number: 10214543
    Abstract: Described herein are methods for the manufacture of ceftolozane and related compounds, as well as compositions comprising the same.
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: February 26, 2019
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Kristos Adrian Moshos, Valdas Jurkauskas, Giovanni Fogliato, Manuel Scanu, Michele Benotti
  • SYNTHESIS OF CEPHALOSPORIN COMPOUNDS
    Publication number: 20180170949
    Abstract: Described herein are methods for the manufacture of ceftolozane and related compounds, as well as compositions comprising the same.
    Type: Application
    Filed: December 18, 2015
    Publication date: June 21, 2018
    Applicant: MERCK SHARP & DOHME CORP.
    Inventors: Kristos Adrian MOSHOS, Valdas JURKAUSKAS, Giovanni FOGLIATO, Manuel SCANU, Michele BENOTTI
  • Reactions of thiadiazolyl-oximinoacetic acid derivative compounds
    Patent number: 9695196
    Abstract: This disclosure relates to an improved synthesis of cephalosporin antibiotic compounds such as ceftolozane, and compositions and methods of use thereof. Thiadiazolyl-oximinoacetic acid compounds such as TATD can be reacted to yield the activated thiadiazolyl-oximinoacetic acid methanesulfonate ester compounds useful in the manufacture of cephalosporin antibiotic compounds.
    Type: Grant
    Filed: June 19, 2015
    Date of Patent: July 4, 2017
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Kristos Adrian Moshos, Valdas Jurkauskas, Manuel Scanu, Michele Benotti
  • REACTIONS OF THIADIAZOLYL-OXIMINOACETIC ACID DERIVATIVE COMPOUNDS
    Publication number: 20170129906
    Abstract: This disclosure relates to an improved synthesis of cephalosporin antibiotic compounds such as ceftolozane, and compositions and methods of use thereof. Thiadiazolyl-oximinoacetic acid compounds such as TATD can be reacted to yield the activated thiadiazolyl-oximinoacetic acid methanesulfonate ester compounds useful in the manufacture of cephalosporin antibiotic compounds.
    Type: Application
    Filed: June 19, 2015
    Publication date: May 11, 2017
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Kristos Adrian Moshos, Valdas Jukauskas, Manuel Scanu, Michele Benotti