Abstract: A circuit includes an amplifier and pre-distortion circuit. The amplifier amplifies a modulated signal. The signal pre-distortion circuit performs a feed-forward pre-distortion of the modulated signal in a signal path in which the amplifier resides. The signal pre-distortion circuit includes: i) an envelope detector configured operative to provide an envelope information describing an envelope of the modulated signal; and ii) a built-in test circuit that determines distortion information describing a distortion in the signal path caused by amplitude variations. The signal pre-distortion circuit performs the feed-forward pre-distortion of the modulated signal on the basis of the distortion information.

Abstract: Techniques (implemented in circuit arrangements, methods, computer instructions) are disclosed which permit digital pre-distortion for amplifiers. A common signal source provides a common analog signal from a digital input signal; a plurality of amplifiers amplifies a split signal which is a split version of the common analog signal; a built-in test circuit is configured to provide distortion information associated to distortion affecting the amplifier. The common signal source implements a signal conditioner to perform, in a signal path of the digital input signal, a feed-forward pre-distortion of the digital input signal according to a pre-distortion relationship mapping the digital input signal onto a pre-distorted version. The signal conditioner is configured to adjust the pre-distortion relationship in dependence on the distortion information.

Abstract: Techniques (implemented in circuit arrangements, methods, computer instructions) are disclosed which permit digital pre-distortion for amplifiers. A common signal source provides a common analog signal from a digital input signal; a plurality of amplifiers amplifies a split signal which is a split version of the common analog signal; a built-in test circuit is configured to provide distortion information associated to distortion affecting the amplifier. The common signal source implements a signal conditioner to perform, in a signal path of the digital input signal, a feed-forward pre-distortion of the digital input signal according to a pre-distortion relationship mapping the digital input signal onto a pre-distorted version. The signal conditioner is configured to adjust the pre-distortion relationship in dependence on the distortion information.

Abstract: A circuit includes an amplifier and pre-distortion circuit. The amplifier amplifies a modulated signal. The signal pre-distortion circuit performs a feed-forward pre-distortion of the modulated signal in a signal path in which the amplifier resides. The signal pre-distortion circuit includes: i) an envelope detector configured operative to provide an envelope information describing an envelope of the modulated signal; and ii) a built-in test circuit that determines distortion information describing a distortion in the signal path caused by amplitude variations. The signal pre-distortion circuit performs the feed-forward pre-distortion of the modulated signal on the basis of the distortion information.

Abstract: The present invention relates to a new process for the preparation of thieno-indole derivatives of formula (Ia) or (Ib), exploiting an asymmetric synthesis for the preparation of key (8S) or (8R) 8-(halomethyl)-1-alkyl-7,8-dihydro-6H-thieno[3,2-e]indol-4-ol intermediates, and to useful intermediate compounds of such process. Thieno-indole derivatives are described and claimed in GB2344818, WO2013/149948 and WO2013/149946, which also disclose processes for their preparation. Thieno-indole enantiopure derivatives can now be advantageously prepared through a new asymmetric synthesis of the key 8-(halomethyl)-7,8-dihydro-6H-thieno[3,2-e]indol intermediates, which, avoiding the chiral resolution step, provides benefits in terms of reducing time and costs of the whole process for their preparation.

Abstract: Devices and methods determining phase offsets are disclosed. A first test signal is transmitted from a first RF circuit part to a second RF circuit part, where a phase difference between the first test signal and a reference signal (ref) is measured. A second test signal is transmitted from the second RF circuit part to the first RF circuit part, where a second phase difference between the second test signal and the reference signal (ref) is measured. Phase offsets of a connection between the first and second circuit parts or of a line supplying the reference signal are determined based on the first and second phase differences.

Abstract: According to an embodiment, a radio frequency delay line is described comprising a first conductor comprising a plurality of first inductors, a second conductor comprising a plurality of second inductors, wherein each of the plurality first inductors corresponds to a respective one of the plurality of second inductors and a plurality of inductor pairs, each inductor pair comprising a first inductor and the corresponding second inductor. For each of the plurality of inductor pairs, the first inductor and the corresponding second inductor are arranged so that an inductor area of the first inductor overlaps with an inductor area of the corresponding second inductor.

Abstract: The present invention relates to a novel class of alkylating agents comprising a thieno[2,3-e]indole moiety tethered to a DNA-binding moiety, which have cytotoxic activity and are useful in treating diseases such as cancer, cellular proliferation disorders and viral infections. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising them and methods of treating diseases utilizing such compounds or the pharmaceutical composition containing them. The invention also relates to the use of this novel class of alkylating agents in the preparation of conjugates.

Abstract: The present invention relates to a new process for the preparation of thieno-indole derivatives of formula (la) or (Ib), exploiting an asymmetric synthesis for the preparation of key (8S) or (8R) 8-(halomethyl)-1-alkyl-7,8-dihydro-6H-thieno[3,2-e]indol-4-ol intermediates, and to useful intermediate compounds of such process. Thieno-indole derivatives are described and claimed in GB2344818, WO2013/149948 and WO2013/149946, which also disclose processes for their preparation. Thieno-indole enantiopure derivatives can now be advantageously prepared through a new asymmetric synthesis of the key 8-(halomethyl)-7,8-dihydro-6H-thieno[3,2-e]indol intermediates, which, avoiding the chiral resolution step, provides benefits in terms of reducing time and costs of the whole process for their preparation.

Abstract: The present invention relates to a new process for the preparation of thieno-indole derivatives of formula (Ia) or (Ib), exploiting an asymmetric synthesis for the preparation of key (8S) or (8R) 8-(halomethyl)-1-alkyl-7,8-dihydro-6H-thieno[3,2-e]indol-4-ol intermediates, and to useful intermediate compounds of such process. Thieno-indole derivatives are described and claimed in GB2344818, WO2013/149948 and WO2013/149946, which also disclose processes for their preparation. Thieno-indole enantiopure derivatives can now be advantageously prepared through a new asymmetric synthesis of the key 8-(halomethyl)-7,8-dihydro-6H-thieno[3,2-e]indol intermediates, which, avoiding the chiral resolution step, provides benefits in terms of reducing time and costs of the whole process for their preparation.

Abstract: The present invention relates to a novel class of alkylating agents comprising a thieno-indole moiety linked to a DNA-binding moiety, which have cytotoxic activity and are useful in treating diseases such as cancer, cellular proliferation disorders and viral infections. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising them and methods of treating diseases utilizing such compounds or the pharmaceutical composition containing them. The invention also relates to the use of this novel class of alkylating agents in the preparation of conjugates.

Abstract: The present invention relates to a new process for the preparation of thieno-indole derivatives of formula (Ia) or (Ib), exploiting an asymmetric synthesis for the preparation of key (8S) or (8R) 8-(halomethyl)-1-alkyl-7,8-dihydro-6H-thieno[3,2-e]indol-4-ol intermediates, and to useful intermediate compounds of such process. Thieno-indole derivatives are described and claimed in GB2344818, WO2013/149948 and WO2013/149946, which also disclose processes for their preparation. Thieno-indole enantiopure derivatives can now be advantageously prepared through a new asymmetric synthesis of the key 8-(halomethyl)-7,8-dihydro-6H-thieno[3,2-e]indol intermediates, which, avoiding the chiral resolution step, provides benefits in terms of reducing time and costs of the whole process for their preparation.

Abstract: According to an embodiment, a radio frequency delay line is described comprising a first conductor comprising a plurality of first inductors, a second conductor comprising a plurality of second inductors, wherein each of the plurality first inductors corresponds to a respective one of the plurality of second inductors and a plurality of inductor pairs, each inductor pair comprising a first inductor and the corresponding second inductor. For each of the plurality of inductor pairs, the first inductor and the corresponding second inductor are arranged so that an inductor area of the first inductor overlaps with an inductor area of the corresponding second inductor.

Abstract: Devices and methods determining phase offsets are disclosed. A first test signal is transmitted from a first RF circuit part to a second RF circuit part, where a phase difference between the first test signal and a reference signal (ref) is measured. A second test signal is transmitted from the second RF circuit part to the first RF circuit part, where a second phase difference between the second test signal and the reference signal (ref) is measured. Phase offsets of a connection between the first and second circuit parts or of a line supplying the reference signal are determined based on the first and second phase differences.

Abstract: According to an embodiment, a radio frequency device includes a phase locked loop circuit, and an automatic gain control circuit, where an output of an automatic gain control circuit is coupled to a reference signal input of the phase locked loop circuit.

Abstract: In accordance with an embodiment a beamforming circuit having a radio frequency (RF) front end and a plurality of beamforming delay circuits coupled to the RF front end. Each of the plurality of beamforming delay circuits includes a common delay circuit and a plurality of individual delay circuits coupled to the common delay circuit. Each of the individual delay circuits are configured to be coupled to an antenna element of a beamforming array.

Abstract: The present invention relates to new morpholinyl anthracycline derivatives which have cytotoxic activity and are useful in treating diseases such as cancer, cellular proliferation disorders and viral infections. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising them and methods of treating diseases utilizing such compounds or the pharmaceutical compositions containing them.

Abstract: The present invention relates to new functionalized morpholinyl anthracycline derivatives which have cytotoxic activity and are useful in treating diseases such as cancer, cellular proliferation disorders and viral infections. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising them and methods of treating diseases utilizing such compounds, or the pharmaceutical compositions containing them. The invention also relates to the use of these derivatives in the preparation of conjugates.

Abstract: In accordance with an embodiment a beamforming circuit having a radio frequency (RF) front end and a plurality of beamforming delay circuits coupled to the RF front end. Each of the plurality of beamforming delay circuits includes a common delay circuit and a plurality of individual delay circuits coupled to the common delay circuit. Each of the individual delay circuits are configured to be coupled to an antenna element of a beamforming array.

Abstract: The present invention relates to conjugates of therapeutically useful anthracyclines with carriers such as polyclonal and monoclonal antibodies, proteins or peptides of natural or synthetic origin; methods for their preparation, pharmaceutical composition containing them and use thereof in treating certain mammalian tumors.