Abstract: A medical device for repairing a lesion in a spinal cord or in a peripheral nerve is provided. The medical device has a flexible support made of expanded polytetrafluoroethylene. Stem cells suitable for being oriented along a first growth direction or a second growth direction are at least partially embedded on the flexible support that is suitable for taking an extended configuration and a wound configuration. In the wound configuration, the flexible support is suitable for being wound around the spinal cord so that the first and second growth directions are substantially statistically parallel to a neuronal extension direction of neurons of the spinal cord. Surgical methods of treating a spinal injury involving using the medical device are also provided.

Abstract: A scaffold for tissue regeneration, particularly for bone regeneration, comprises a three-dimensional supporting structure made of a biocompatible and biodegradable material; the supporting structure is functionalized with secretome, in particular mesenchymal stem cell secretome, preferably in lyophilized form (lyosecretome).

Abstract: A medical device for repairing a lesion in a spinal cord or in a peripheral nerve is provided. The medical device has a flexible support made of expanded polytetrafluoroethylene. Stem cells suitable for being oriented along a first growth direction or a second growth direction are at least partially embedded on the flexible support that is suitable for taking an extended configuration and a wound configuration. In the wound configuration, the flexible support is suitable for being wound around the spinal cord so that the first and second growth directions are substantially statistically parallel to a neuronal extension direction of neurons of the spinal cord. Surgical methods of treating a spinal injury involving using the medical device are also provided.

Abstract: A medical device for repairing injuries to the spinal cord or peripheral nerve has a first flexible substrate supporting first nanoparticles selected from the group consisting of silicon, carbon, gold and titanium, at least partially embedded in a binding layer joined to the first flexible substrate. Each first nanoparticle develops along a preferential direction of development. The nanoparticles are oriented so that, statistically, the preferential direction of development is parallel to a first orientation of growth. Stem cells are at least partially embedded in the binding layer. The first nanoparticles are functionalized so that stem cell differentiation along the first nanoparticles is guided in the first orientation of growth.