Patents by Inventor Michele Cramer

Michele Cramer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Excitation ratiometric fluoroscent biosensor for zinc ion at picomolar levels
    Patent number: 7491545
    Abstract: A highly selective and sensitive of a carbonic anhydrase-based method for measurement of zinc ion by an excitation ratiometric format based on resonance energy transfer: i.e., where the zinc ion level is transduced as the ratio of fluorescence intensities excited at two different excitation wavelengths, is provided. The method can be used very well in a fluorescence microscopy format. A detection limit of about 10 pM in zinc buffered systems, a ten to one thousand-fold improvement on the Fura indicators (which respond to Ca and Mg as well), and a one hundred thousand-fold improvement on the recently described FuraZin-1 is achieved.
    Type: Grant
    Filed: September 30, 2003
    Date of Patent: February 17, 2009
    Inventors: Richard Thompson, Michele Cramer, Carol Ann Fierke, Hui Hui Zeng, Rebecca Bozym
  • Electrically insulative powder coatings and compositions and methods for making them
    Publication number: 20050065294
    Abstract: The present invention provides powder compositions comprising from 20 to 90 phr of one or more than one silicone resin having a glass transition temperature (Tg) of at least 40° C., from 10 to 80 phr of one or more than one resin chosen from glycidyl functional acrylic resin, mixtures of aromatic epoxy resin or novolac resin with carboxyl functional acrylic resin carboxyl functional polyester resin or glycidyl functional acrylic resin, and one or more than one filler, such as wollastonite, barium sulfate, mica, talc, alumina, layered silicates like montmorillonite, and mixtures thereof. The one or more than one silicone resin may or may not be flaked and may or may not contain silanol groups. The compositions of the present invention provide single layer or multilayer powder coatings that are free of voids larger than 30 ?m in diameter, and which may meet the UL Class H (180° C.) certification for electrical insulation applications.
    Type: Application
    Filed: September 13, 2004
    Publication date: March 24, 2005
    Inventors: Michele Cramer, Glenn Correll, Nancy Osenbach
  • Excitation ratiometric fluorescent biosensor for zinc ion at picomolar levels
    Publication number: 20040185518
    Abstract: A highly selective and sensitive of a carbonic anhydrase-based method for measurement of zinc ion by an excitation ratiometric format based on resonance energy transfer: i.e., where the zinc ion level is transduced as the ratio of fluorescence intensities excited at two different excitation wavelengths, is provided. The method can be used very well in a fluorescence microscopy format. A detection limit of about 10 pM in zinc buffered systems, a ten to one thousand-fold improvement on the Fura indicators (which respond to Ca and Mg as well), and a one hundred thousand-fold improvement on the recently described FuraZin-1 is achieved.
    Type: Application
    Filed: September 30, 2003
    Publication date: September 23, 2004
    Inventors: Richard Thompson, Michele Cramer, Carol Ann Fierke, Hui Hui Zeng, Rebecca Bozym