Patents by Inventor Michele F. Mitchell

Michele F. Mitchell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diagnosis of dysplasia using laser induced fluorescence
    Patent number: 5623932
    Abstract: Apparatus and in vivo methods to distinguish normal and abnormal cervical tissue and to detect cervical intraepithelial neoplasia (CIN) in a diagnostic cervical tissue sample. Induced fluorescence intensity spectra from known normal cervical tissue and a diagnostic tissue sample are obtained from the same patient. Peak fluorescence intensity values for normal tissue samples are averaged, as are slope measurements from predetermined portions of spectra induced in both known normal cervical tissue and the diagnostic tissue sample. Peak fluorescence intensities of diagnostic tissue spectra are divided by average peak fluorescence intensity values for normal tissue in the same patient to yield relative peak fluorescence intensity values. Normal and abnormal cervical tissues are distinguished using a predetermined empirical discriminant function of slope measurements derived from normal tissue spectra and relative peak fluorescence intensity measurements in the same patient.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: April 29, 1997
    Assignee: Board of Regents, The University of Texas System
    Inventors: Nirmala Ramanujam, Anita Mahadevan, Rebecca R. Richards-Kortum, Michele F. Mitchell, Sharon Thomsen
  • Optical method for the detection of cervical neoplasias using fluorescence spectroscopy
    Patent number: 5612540
    Abstract: A method for detecting tissue abnormality, particularly precancerous cervical tissue, through fluorescence spectroscopy is disclosed. In vitro fluorescence measurements over a variety of different fluorescence spectra are used to screen tissue samples. Using a principal component analysis (PCA), it is possible to discriminate between normal and dysplastic tissues with relatively low false-positive and false-negative results.
    Type: Grant
    Filed: March 31, 1995
    Date of Patent: March 18, 1997
    Assignee: Board of Regents, The University of Texas Systems
    Inventors: Rebecca Richards-Kortum, Gregg Staerkel, Youseph Yazdi, Michele F. Mitchell
  • Diagnosis of dysplasia using laser induced fluoroescence
    Patent number: 5421339
    Abstract: Apparatus and in vivo methods to distinguish normal and abnormal cervical tissue and to detect cervical intraepithelial neoplasia (CIN) in a diagnostic cervical tissue sample. Induced fluorescence intensity spectra from known normal cervical tissue and a diagnostic tissue sample are obtained from the same patient. Peak fluorescence intensity values for normal tissue samples are averaged, as are slope measurements from predetermined portions of spectra induced in both known normal cervical tissue and the diagnostic tissue sample. Peak fluorescence intensities of diagnostic tissue spectra are divided by average peak fluorescence intensity values for normal tissue in the same patient to yield relative peak fluorescence intensity values. Normal and abnormal cervical tissues are distinguished using a predetermined empirical discriminant function of slope measurements derived from normal tissue spectra and relative peak fluorescence intensity measurements in the same patient.
    Type: Grant
    Filed: May 12, 1993
    Date of Patent: June 6, 1995
    Assignee: Board of Regents, The University of Texas System
    Inventors: Nirmala Ramanujam, Anita Mahadevan, Rebecca R. Richards-Kortum, Michele F. Mitchell, Sharon Thomsen