Abstract: An analyzer system includes a motor, a dock coupled to the motor, and a cartridge held in the dock. The cartridge includes a fluid circuit configured to receive a sample, isolate a target analyte of the sample, and collect a quantity of a first label that is proportional to a quantity of the target analyte in the sample. The fluid circuit includes a sample port configured to receive a sample, a mixing chamber in fluid communication with the sample port, and a fluid inlet port in fluid communication with the mixing chamber. The fluid circuit includes an isolated path extending from the fluid inlet port to the mixing chamber. The system also includes a fluid delivery line configured to be coupled to the fluid inlet port so as to deliver fluid to the cartridge through the fluid inlet port and push the fluid along the isolated path toward the mixing chamber.

Abstract: An analyzer system includes a cartridge configured to receive a sample. The cartridge has a plurality of chambers for isolating a target analyte of the sample and collecting a quantity of a first label that is proportional to a quantity of the target analyte in the sample. The system includes an analyzer with a first electromagnetic radiation source a first detector and a controller. The first electromagnetic radiation source is configured to provide electromagnetic radiation to form an interrogation space within a detection chamber of the cartridge. The first detector is configured to detect electromagnetic radiation emitted in the interrogation space by the first label if the first label is present in the interrogation space. The controller is configured to identify the presence of the target analyte in the sample based on electromagnetic radiation detected by the first detector.

Abstract: Analyzers and analyzer systems that include an analyzer for determining multiple label species, methods of using the analyzer and analyzer systems to analyze samples, are disclosed herein. The analyzer includes one or more sources of electromagnetic radiation to provide electromagnetic radiation at wavelengths within the excitation bands of one or more fluorophore species to an interrogation space that is translated through the sample to detect the presence or absence of molecules of different target analytes. The analyzer may also include one or more detectors configured to detect electromagnetic radiation emitted from the one or more fluorophore species. The analyzer for determining multiple target molecule species provided herein is useful for diagnostics because the concentration of multiple species of target molecules may be determined in a single sample and with a single system.

Abstract: Analyzers and analyzer systems that include an analyzer for determining multiple label species, methods of using the analyzer and analyzer systems to analyze samples, are disclosed herein. The analyzer includes one or more sources of electromagnetic radiation to provide electromagnetic radiation at wavelengths within the excitation bands of one or more fluorophore species to an interrogation space that is translated through the sample to detect the presence or absence of molecules of different target analytes. The analyzer may also include one or more detectors configured to detect electromagnetic radiation emitted from the one or more fluorophore species. The analyzer for determining multiple target molecule species provided herein is useful for diagnostics because the concentration of multiple species of target molecules may be determined in a single sample and with a single system.

Abstract: Education and training in the procedures and materials for cell growth and protein expression are provided by an integrated system of modules, each fully equipped with reagents, for the entire span of procedures beginning with cell plating and inoculation and extending through protein expression, growth, purification, and assay, plus an instruction manual that sets forth all of the procedures, and in certain cases an assessment module. The system is supplied with bacterial cells already transformed for expression of proteins that are selected for their known expression procedures and properties, and is adaptable to any known protein.