Abstract: Disclosed are an antibody able to recognise and specifically bind the CLIC1 protein located on the cell membrane and inhibit its ion channel function; the uses of said antibody in the diagnostic and therapeutic fields; and pharmaceutical compositions containing the antibody.

Abstract: Disclosed are methods of treating a subject having cancer comprising applying alternating electric fields to a target site of the subject for a period of time, the alternating electric fields having a frequency and field strength, wherein the target site comprises one or more cancer cells, and administering an ion channel inhibitor to the subject. Disclosed are methods of killing a cancer cell comprising exposing the cancer cell to alternating electric fields for a period of time, the alternating electric fields having a frequency and field strength, and contacting the cancer cell with an ion channel inhibitor, wherein cancer cells are killed.

Abstract: Bio-electromechanical device capable to convert electrochemical potential energy stored in a both animal or plant cellular system to mechanical energy. This bio-electromechanical device has sizes varying in the order of microns, with maximum electric voltages near 100 mV, currents in the order of nA and associated power in the order of 10?10 W. The device uses the membrane potential, and specifically the action potential activation of an excitable cell, to power an electromechanical circuit which comprises at least a resistance, a capacitor and a mechanical oscillator connected to one of the capacitor plates. The resulting system is a bio-electromechanical system capable of self-oscillations triggered by a limit cycle in which the oscillating mechanical element, having different possible constructions, is the member that produces mechanical energy. The latter component can directly drive a user micro-device.