Patents by Inventor Michele Negri

Michele Negri has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11897826
    Abstract: The present invention relates to a hypergolic two-component system for rocket engines, including a fuel and an oxidising agent provided in a manner separated from one another and can be reacted in a rocket engine by bringing them into contact with one another. The fuel is an ionic liquid comprising a thiocyanate anion and one or more cations. The cation or cations are selected from one or more imidazolium ions of the general formula I, triazolium ions of the general formula II or III, and/or tetrazolium ions of the general formula IV, where R1 is a C1- to C6-alkyl radical or a C2- to C6-alkenyl radical, where R2 is hydrogen or a C1- to C6-alkyl radical or a C2- to C6-alkenyl radical, and where X1, X2 and X3 are each independently hydrogen, a C1- to C6-alkyl radical or a C2- to C6-alkenyl radical, and the oxidising agent comprises hydrogen peroxide.
    Type: Grant
    Filed: July 2, 2020
    Date of Patent: February 13, 2024
    Assignee: Deutsches Zentrum fuer Luft- und Raumfahrt e.V.
    Inventors: Felix Lauck, Michele Negri, Dominic Freudenmann
  • Patent number: 11731946
    Abstract: The present application provides malonamide compounds, and derivatives thereof (e.g., N-aryl malonamides (NAM), acetamides, oxalamides, and the like), that are useful, for example, for the treatment of acute, chronic/persistent, and/or relapsing infections. Pharmaceutical compositions, methods of treating diseases (e.g., bacterial infections), and methods of reducing bacterial virulence are also provided.
    Type: Grant
    Filed: October 19, 2018
    Date of Patent: August 22, 2023
    Assignees: The General Hospital Corporation, Aptuit (Verona) SRL, An Evotec Company
    Inventors: Laurence Rahme, Francois Lepine, Damien Maura, Carmela Napolitano, Antonio Felici, Michele Negri, Stefano Fontana, Daniele Andreotti
  • Publication number: 20210355046
    Abstract: The present invention relates to a hypergolic two-component system for rocket engines, including a fuel and an oxidising agent provided in a manner separated from one another and can be reacted in a rocket engine by bringing them into contact with one another. The fuel is an ionic liquid comprising a thiocyanate anion and one or more cations. The cation or cations are selected from one or more imidazolium ions of the general formula I, triazolium ions of the general formula II or III, and/or tetrazolium ions of the general formula IV, where R1is a C1- to C6-alkyl radical or a C2- to C6-alkenyl radical, where R2 is hydrogen or a C1- to C6-alkyl radical or a C2- to C6-alkenyl radical, and where X1, X2 and X3 are each independently hydrogen, a C1- to C6-alkyl radical or a C2- to C6-alkenyl radical, and the oxidising agent comprises hydrogen peroxide.
    Type: Application
    Filed: July 2, 2020
    Publication date: November 18, 2021
    Inventors: Felix Lauck, Michele Negri, Dominic Freudenmann
  • Publication number: 20210130306
    Abstract: The present application provides malonamide compounds, and derivatives thereof (e.g., N-aryl malonamides (NAM), acetamides, oxalamides, and the like), that are useful, for example, for the treatment of acute, chronic/persistent, and/or relapsing infections. Pharmaceutical compositions, methods of treating diseases (e.g., bacterial infections), and methods of reducing bacterial virulence are also provided.
    Type: Application
    Filed: October 19, 2018
    Publication date: May 6, 2021
    Inventors: Laurence Rahme, Francois Lepine, Damien Maura, Carmela Napolitano, Antonio Felici, Michele Negri, Stefano Fontana, Daniele Andreotti
  • Publication number: 20210017097
    Abstract: The present invention relates to a hypergolic two-component system for rocket engines, including a fuel and an oxidising agent provided in a manner separated from one another and can be reacted in a rocket engine by bringing them into contact with one another. The fuel is an ionic liquid comprising a thiocyanate anion and one or more cations. The cation or cations are selected from one or more imidazolium ions of the general formula I, triazolium ions of the general formula II or III, and/or tetrazolium ions of the general formula IV, where R1is a C1- to C6-alkyl radical or a C2- to C6-alkenyl radical, where R2 is hydrogen or a C1- to C6-alkyl radical or a C2- to C6-alkenyl radical, and where X1, X2 and X3 are each independently hydrogen, a C1- to C6-alkyl radical or a C2- to C6-alkenyl radical, and the oxidising agent comprises hydrogen peroxide.
    Type: Application
    Filed: July 2, 2020
    Publication date: January 21, 2021
    Inventors: Felix Lauck, Michele Negri, Dominic Freudenmann