Abstract: Sample cartridge, valve assembly and processing methods for providing mechanical lysis, chemical lysis or both for a given fluid sample are provided herein. Such systems can include a sample processing cartridge having a valve assembly configured for transport of the processing of fluid sample within the sample cartridge. The valve assembly can include a valve body and cap that secure a filter therebetween and facilitate inflow of mechanical or chemical lysing agents as needed for a fluid sample. Assay workflows for performing both mechanical and chemical lysis of a fluid sample within the same workflow of a single universal sample cartridge are also provided.

Abstract: Systems and methods are disclosed for controlling the flow of fluids in a fluid infusion system. The system may include first and second fluid containers, first and second tubes coupled to the first and second fluid containers, and an external valve coupled to the second tube and configured to be attached to the first tube. The valve may be configured to shape the first tube to form a valve region which is opened or closed by an actuating element in the valve that is driven by hydrostatic pressure from the second tube. A full second container may generate a pressure that is concentrated through a diaphragm onto a pin which presses on the shaped first tube region, closing it to allow only fluid from the second container to flow. When the fluid level in the second line falls reducing pressure, the pin's force reduces until the first tube is opened.

Abstract: Systems and methods are disclosed for controlling the flow of fluids in a fluid infusion system. The system may include first and second fluid containers, first and second tubes coupled to the first and second fluid containers, and an external valve coupled to the second tube and configured to be attached to the first tube. The valve may be configured to shape the first tube to form a valve region which is opened or closed by an actuating element in the valve that is driven by hydrostatic pressure from the second tube. A full second container may generate a pressure that is concentrated through a diaphragm onto a pin which presses on the shaped first tube region, closing it to allow only fluid from the second container to flow. When the fluid level in the second line falls reducing pressure, the pin's force reduces until the first tube is opened.