Patents by Inventor Michelle A. O'Malley
Michelle A. O'Malley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12098171Abstract: The present invention provides for a hybrid sugar transporter having an altered sugar transporter activity and comprising at least a first transmembrane domain (TMD) from a first sugar transporter and a second TMD from a second sugar transporter, wherein the first sugar transporter and the second sugar transporter are heterologous to each other.Type: GrantFiled: December 10, 2021Date of Patent: September 24, 2024Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Michelle A. O'Malley, Igor A. Podolsky, Susanna Seppala
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Patent number: 12037371Abstract: Provided herein are novel proteins and protein domains from newly discovered anaerobic fungal species. The anaerobic fungal species have unique enzymatic capabilities, including the ability to digest diverse lignocellulosic biomass feedstocks and to synthesize secondary metabolites. The scope of the invention encompasses novel engineered proteins comprising glycoside hydrolase enzymes, dockerin domains, carbohydrate binding domains, and polyketide synthase enzymes. The invention further encompasses artificial cellulosomes comprising novel proteins and domains of the invention. The scope of the invention further includes novel nucleic acid sequences coding for the engineered proteins of the invention, and methods of using such engineered organisms to degrade lignocellulosic biomass and to create polyketides.Type: GrantFiled: May 17, 2021Date of Patent: July 16, 2024Assignee: The Regents of the University of CaliforniaInventors: Michelle O'Malley, Kevin Solomon, Charles Haitjema
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Publication number: 20230002454Abstract: The present invention provides for a hybrid sugar transporter having an altered sugar transporter activity and comprising at least a first transmembrane domain (TMD) from a first sugar transporter and a second TMD from a second sugar transporter, wherein the first sugar transporter and the second sugar transporter are heterologous to each other.Type: ApplicationFiled: December 10, 2021Publication date: January 5, 2023Inventors: Michelle A. O'Malley, Igor A. Podolsky, Susanna Seppala
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Publication number: 20210269492Abstract: Provided herein are novel proteins and protein domains from newly discovered anaerobic fungal species. The anaerobic fungal species have unique enzymatic capabilities, including the ability to digest diverse lignocellulosic biomass feedstocks and to synthesize secondary metabolites. The scope of the invention encompasses novel engineered proteins comprising glycoside hydrolase enzymes, dockerin domains, carbohydrate binding domains, and polyketide synthase enzymes. The invention further encompasses artificial cellulosomes comprising novel proteins and domains of the invention. The scope of the invention further includes novel nucleic acid sequences coding for the engineered proteins of the invention, and methods of using such engineered organisms to degrade lignocellulosic biomass and to create polyketides.Type: ApplicationFiled: May 17, 2021Publication date: September 2, 2021Applicant: The Regents of the University of CaliforniaInventors: Michelle O'Malley, Kevin Solomon, Charles Haitjema
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Patent number: 11021524Abstract: Provided herein are novel proteins and protein domains from newly discovered anaerobic fungal species. The anaerobic fungal species have unique enzymatic capabilities, including the ability to digest diverse lignocellulosic biomass feedstocks and to synthesize secondary metabolites. The scope of the invention encompasses novel engineered proteins comprising glycoside hydrolase enzymes, dockerin domains, carbohydrate binding domains, and polyketide synthase enzymes. The invention further encompasses artificial cellulosomes comprising novel proteins and domains of the invention. The scope of the invention further includes novel nucleic acid sequences coding for the engineered proteins of the invention, and methods of using such engineered organisms to degrade lignocellulosic biomass and to create polyketides.Type: GrantFiled: June 10, 2020Date of Patent: June 1, 2021Assignee: The Regents of the University of CaliforniaInventors: Michelle O'Malley, Kevin Solomon, Charles Haitjema
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Publication number: 20200299338Abstract: Provided herein are novel proteins and protein domains from newly discovered anaerobic fungal species. The anaerobic fungal species have unique enzymatic capabilities, including the ability to digest diverse lignocellulosic biomass feedstocks and to synthesize secondary metabolites. The scope of the invention encompasses novel engineered proteins comprising glycoside hydrolase enzymes, dockerin domains, carbohydrate binding domains, and polyketide synthase enzymes. The invention further encompasses artificial cellulosomes comprising novel proteins and domains of the invention. The scope of the invention further includes novel nucleic acid sequences coding for the engineered proteins of the invention, and methods of using such engineered organisms to degrade lignocellulosic biomass and to create polyketides.Type: ApplicationFiled: June 10, 2020Publication date: September 24, 2020Applicant: The Regents of the University of CaliforniaInventors: Michelle O'Malley, Kevin Solomon, Charles Haitjema
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Patent number: 10717768Abstract: Provided herein are novel proteins and protein domains from newly discovered anaerobic fungal species. The anaerobic fungal species have unique enzymatic capabilities, including the ability to digest diverse lignocellulosic biomass feedstocks and to synthesize secondary metabolites. The scope of the invention encompasses novel engineered proteins comprising glycoside hydrolase enzymes, dockerin domains, carbohydrate binding domains, and polyketide synthase enzymes. The invention further encompasses artificial cellulosomes comprising novel proteins and domains of the invention. The scope of the invention further includes novel nucleic acid sequences coding for the engineered proteins of the invention, and methods of using such engineered organisms to degrade lignocellulosic biomass and to create polyketides.Type: GrantFiled: December 8, 2016Date of Patent: July 21, 2020Assignee: The Regents of the University of CaliforniaInventors: Michelle O'Malley, Kevin Solomon, Charles Haitjema
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Patent number: 10676766Abstract: The invention relates to an engineered eukaryotic microorganism into which a gene encoding an acyl-CoA dehydrogenase is introduced and a method for producing methacrylic acid esters such as MMA and MMA-CoA and precursors thereof using the microorganism.Type: GrantFiled: April 20, 2018Date of Patent: June 9, 2020Assignees: The Regents of the University of California, Mitsubishi Chemical CorporationInventors: Michelle O'Malley, Kevin Solomon, Wataru Mizunashi, Fujio Yu
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Publication number: 20180362597Abstract: Provided herein are novel proteins and protein domains from newly discovered anaerobic fungal species. The anaerobic fungal species have unique enzymatic capabilities, including the ability to digest diverse lignocellulosic biomass feedstocks and to synthesize secondary metabolites. The scope of the invention encompasses novel engineered proteins comprising glycoside hydrolase enzymes, dockerin domains, carbohydrate binding domains, and polyketide synthase enzymes. The invention further encompasses artificial cellulosomes comprising novel proteins and domains of the invention. The scope of the invention further includes novel nucleic acid sequences coding for the engineered proteins of the invention, and methods of using such engineered organisms to degrade lignocellulosic biomass and to create polyketides.Type: ApplicationFiled: December 8, 2016Publication date: December 20, 2018Applicant: The Regents of the University of CaliforniaInventors: Michelle O'Malley, Kevin Solomon, Charles Haitjema
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Publication number: 20180346942Abstract: The invention relates to an engineered eukaryotic microorganism into which a gene encoding an acyl-CoA dehydrogenase is introduced and a method for producing methacrylic acid esters such as MMA and MMA-CoA and precursors thereof using the microorganism.Type: ApplicationFiled: April 20, 2018Publication date: December 6, 2018Applicants: The Regents of the University of California, Mitsubishi Chemical CorporationInventors: Michelle O'MALLEY, Kevin SOLOMON, Wataru MIZUNASHI, Fujio YU