Patents by Inventor Michelle Arkin

Michelle Arkin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds and methods for promoting stress resistance
    Patent number: 11413278
    Abstract: Disclosed herein, inter alia, are compounds and methods useful for increasing stress resistance.
    Type: Grant
    Filed: October 7, 2016
    Date of Patent: August 16, 2022
    Assignee: The Regents of the University of California
    Inventors: Cynthia Kenyon, Peichuan Zhang, James Cregg, Kean-Hooi Ang, Michelle Arkin
  • METHODS OF TREATMENT USING PHENYL INDOLE ALLOSTERIC INHIBITORS OF P97 ATPASE
    Publication number: 20220112179
    Abstract: The present invention is directed to methods of inhibiting p97 and compounds and compositions useful in such methods. Diseases and conditions the can be treated with the compounds and compositions of the invention include, but are not limited to, cancer and neurodegenerative disorders susceptible to treatment by inhibition of p97.
    Type: Application
    Filed: December 20, 2021
    Publication date: April 14, 2022
    Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, National Institutes of Health, A Component of the United States Department of Health and Human Servi, The Regents of the University of California
    Inventors: Donna M. Huryn, Peter Wipf, Matthew G. LaPorte, Raffaele Colombo, Marina Kovaliov, Chaemin Lim, Celeste Natalie Alverez, Zhizhou Yue, Lalith Palitha Samankumara, Alexander Julian Chatterley, Yongzhao Yan, Mary Liang, Neal J. Green, Eric T. Baldwin, William J. Moore, Michelle Arkin, R. Jeffrey Neitz, Kean-Hooi Ang, Clifford Bryant, Stacie Bulfer
  • Phenyl indole allosteric inhibitors of P97 ATPase
    Patent number: 11247985
    Abstract: The present invention is directed to methods of inhibiting p97 and compounds and compositions useful in such methods. Diseases and conditions the can be treated with the compounds and compositions of the invention include, but are not limited to, cancer and neurodegenerative disorders susceptible to treatment by inhibition of p97.
    Type: Grant
    Filed: January 21, 2020
    Date of Patent: February 15, 2022
    Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, National Institutes of Health, A Component of the U.S. Department of Hearth and Human Services, The Regents of the University of California
    Inventors: Donna M. Huryn, Peter Wipf, Matthew G. LaPorte, Raffaele Colombo, Marina Kovaliov, Chaemin Lim, Celeste Natalie Alverez, Zhizhou Yue, Lalith Palitha Samankumara, Alexander Julian Chatterley, Yongzhao Yan, Mary Liang, Neal J. Green, Eric T. Baldwin, William J. Moore, Michelle Arkin, R. Jeffrey Neitz, Kean-Hooi Ang, Clifford Bryant, Stacie Bulfer
  • In vitro assays for inhibition of microglial activation
    Patent number: 11099172
    Abstract: The present invention provides cell-based assays, including high throughput cell-based assays, for identification of candidate therapeutic agents with the ability to inhibit microglial activation in vivo in response to different ligands.
    Type: Grant
    Filed: April 2, 2018
    Date of Patent: August 24, 2021
    Assignees: The J. David Gladstone Insitutes, The Regents of the University of California
    Inventors: Katerina Akassoglou, Michelle Arkin, Kean-Hooi Ang, Anke Meyer-Franke, Christopher Wilson
  • PHENYL INDOLE ALLOSTERIC INHIBITORS OF P97 ATPASE
    Publication number: 20200157082
    Abstract: The present invention is directed to methods of inhibiting p97 and compounds and compositions useful in such methods. Diseases and conditions the can be treated with the compounds and compositions of the invention include, but are not limited to, cancer and neurodegenerative disorders susceptible to treatment by inhibition of p97.
    Type: Application
    Filed: January 21, 2020
    Publication date: May 21, 2020
    Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, National Institutes of Health, A Component of the United States Department of Health and Human, The Regents of the University of California
    Inventors: Donna M. Huryn, Peter Wipf, Matthew G. LaPorte, Raffaele Colombo, Marina Kovaliov, Chaemin Lim, Celeste Natalie Alverez, Zhizhou Yue, Lalith Palitha Samankumara, Alexander Julian Chatterley, Yongzhao Yan, Mary Liang, Neal J. Green, Eric T. Baldwin, William J. Moore, Michelle Arkin, R. Jeffrey Neitz, Kean-Hooi Ang, Clifford Bryant, Stacie Bulfer
  • Phenyl indole allosteric inhibitors of p97 ATPase
    Patent number: 10633370
    Abstract: The present invention is directed to methods of inhibiting p97 and compounds and compositions useful in such methods. Diseases and conditions the can be treated with the compounds and compositions of the invention include, but are not limited to, cancer and neurodegenerative disorders susceptible to treatment by inhibition of p97.
    Type: Grant
    Filed: October 20, 2016
    Date of Patent: April 28, 2020
    Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, National Institutes of Health, A Component of the U.S. Department of Health and Human Services, The Regents of the University of California
    Inventors: Donna M. Huryn, Peter Wipf, Matthew G. LaPorte, Raffaele Colombo, Marina Kovaliov, Chaemin Lim, Celeste Natalie Alverez, Zhizhou Yue, Lalith Palitha Samankumara, Alexander Julian Chatterley, Yongzhao Yan, Mary Liang, Neal J. Green, Eric T. Baldwin, William J. Moore, Michelle Arkin, R. Jeffrey Neitz, Kean-Hooi Ang, Clifford Bryant, Stacie Bulfer
  • IN VITRO ASSAYS FOR INHIBITION OF MICROGLIAL ACTIVATION
    Publication number: 20190064152
    Abstract: The present invention provides cell-based assays, including high throughput cell-based assays, for identification of candidate therapeutic agents with the ability to inhibit microglial activation in vivo in response to different ligands.
    Type: Application
    Filed: April 2, 2018
    Publication date: February 28, 2019
    Inventors: Katerina Akassoglou, Michelle Arkin, Kean-Hooi Ang, Anke Meyer-Franke, Christopher Wilson
  • PHENYL INDOLE ALLOSTERIC INHIBITORS OF P97 ATPASE
    Publication number: 20180319778
    Abstract: The present invention is directed to methods of inhibiting p97 and compounds and compositions useful in such methods. Diseases and conditions the can be treated with the compounds and compositions of the invention include, but are not limited to, cancer and neurodegenerative disorders susceptible to treatment by inhibition of p97.
    Type: Application
    Filed: October 20, 2016
    Publication date: November 8, 2018
    Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, National Institute of Health, A Component of the U.S Department of Health and Human Services, The Regents of the University of California
    Inventors: Donna M. HURYN, Peter Wipf, Matthew G. LaPorte, Raffaele Colombo, Marina Kovaliov, Chaemin Lim, Celeste Natalie Alverez, Zhizhou Yue, Lalith Palitha Samankumara, Alexander Julian Chatterley, Yongzhao Yan, Mary Liang, Neal J. Green, Eric T. Baldwin, William J. Moore, Michelle Arkin, R. Jeffrey Neilz, Kean-Hooi Ang, Cliffford Bryant, Stacie Bulfer
  • SNS-595 AND METHODS OF USING THE SAME
    Publication number: 20180316309
    Abstract: The present invention relates to SNS-595 and methods of treating cancer using the same.
    Type: Application
    Filed: April 27, 2018
    Publication date: November 1, 2018
    Inventors: Michelle Arkin, Jennifer Hyde, Duncan Walker, Jasmin Wright
  • COMPOUNDS AND METHODS FOR PROMOTING STRESS RESISTANCE
    Publication number: 20180289682
    Abstract: Disclosed herein, inter alia, are compounds and methods useful for increasing stress resistance.
    Type: Application
    Filed: October 7, 2016
    Publication date: October 11, 2018
    Inventors: Cynthia Kenyon, Peichuan Zhang, James Cregg, Kean-Hooi Ang, Michelle Arkin
  • SNS-595 and methods of using the same
    Patent number: 9980949
    Abstract: The present invention relates to SNS-595 and methods of treating cancer using the same.
    Type: Grant
    Filed: August 18, 2014
    Date of Patent: May 29, 2018
    Assignee: Sunesis Pharmaceuticals, Inc.
    Inventors: Michelle Arkin, Jennifer Hyde, Duncan Walker, Jasmin Wright
  • METHODS OF USING (+)-1,4-DIHYDRO-7-[(3S,4S)-3-METHOXY-4-(METHYLAMINO)-1-PYRROLIDINYL]-4-OXO-1-(2-THIAZOLYL)-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID FOR TREATMENT OF CANCER
    Publication number: 20180098975
    Abstract: Methods of treating, preventing or managing cancer, including certain leukemias are disclosed. The methods encompass the administration of enantiomerically pure (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid. Also provided are methods of treatment using this compound with chemotherapy, radiation therapy, hormonal therapy, biological therapy or immunotherapy. Pharmaceutical compositions and single unit dosage forms suitable for use in the methods are also disclosed.
    Type: Application
    Filed: September 25, 2017
    Publication date: April 12, 2018
    Inventors: Daniel C. Adelman, Jeffrey A. Silverman, Michelle Arkin, Jennifer Hyde, Duncan Walker, Jasmin Wright
  • SNS-595 AND METHODS OF USING THE SAME
    Publication number: 20170373636
    Abstract: The present invention relates to SNS-595 and methods of treating cancer using the same.
    Type: Application
    Filed: August 18, 2014
    Publication date: December 28, 2017
    Inventors: MICHELLE ARKIN, JENNIFER HYDE, DUNCAN WALKER, JASMIN WRIGHT
  • IN VITRO ASSAYS FOR INHIBITION OF MICROGLIAL ACTIVATION
    Publication number: 20170003280
    Abstract: The present invention provides cell-based assays, including high throughput cell-based assays, for identification of candidate therapeutic agent with no known agents with the ability to inhibit microglial activation in vivo in response to different ligands.
    Type: Application
    Filed: January 9, 2015
    Publication date: January 5, 2017
    Inventors: Katerina Akassoglou, Michelle Arkin, Kean-Hooi Ang, Anke Meyer-Franke, Christopher Wilson
  • SNS-595 AND METHODS OF USING THE SAME
    Publication number: 20150190381
    Abstract: The present invention relates to SNS-595 and methods of treating cancer using the same.
    Type: Application
    Filed: August 18, 2014
    Publication date: July 9, 2015
    Inventors: MICHELLE ARKIN, JENNIFER HYDE, DUNCAN WALKER, JASMIN WRIGHT
  • SNS-595 and methods of using the same
    Patent number: 8822493
    Abstract: The present invention relates to SNS-595 and methods of treating cancer using the same.
    Type: Grant
    Filed: March 11, 2013
    Date of Patent: September 2, 2014
    Assignee: Sunesis Pharmaceuticals, Inc.
    Inventors: Michelle Arkin, Jennifer Hyde, Duncan Walker, Jasmin Wright
  • METHODS OF USING (+)-1,4-DIHYDRO-7-[(3S,4S)-3-METHOXY-4-(METHYLAMINO)-1-PYRROLIDINYL]-4-OXO-1-(2-THIAZOLYL)-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID FOR TREATMENT OF CANCER
    Publication number: 20140205680
    Abstract: Methods of treating, preventing or managing cancer, including certain leukemias are disclosed. The methods encompass the administration of enantiomerically pure (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid. Also provided are methods of treatment using this compound with chemotherapy, radiation therapy, hormonal therapy, biological therapy or immunotherapy. Pharmaceutical compositions and single unit dosage forms suitable for use in the methods are also disclosed.
    Type: Application
    Filed: October 17, 2013
    Publication date: July 24, 2014
    Applicant: SUNESIS PHARMACEUTICALS, INC.
    Inventors: Daniel C. Adelman, Jeffrey A. Silverman, Michelle Arkin, Jennifer Hyde, Duncan Walker, Jasmin Wright
  • SNS-595 AND METHODS OF USING THE SAME
    Publication number: 20130244967
    Abstract: The present invention relates to SNS-595 and methods of treating cancer using the same.
    Type: Application
    Filed: March 11, 2013
    Publication date: September 19, 2013
    Applicant: Sunesis Pharmaceuticals, Inc.
    Inventors: MICHELLE ARKIN, JENNIFER HYDE, DUNCAN WALKER, JASMIN WRIGHT
  • SNS-595 AND METHODS OF USING THE SAME
    Publication number: 20110263524
    Abstract: The present invention relates to SNS-595 and methods of treating cancer using the same.
    Type: Application
    Filed: April 27, 2011
    Publication date: October 27, 2011
    Inventors: Michelle Arkin, Jennifer Hyde, Duncan Walker, Jasmin Wright
  • Therapeutic combinations comprising (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid
    Patent number: 7968565
    Abstract: The present invention relates to SNS-595 and methods of treating cancer using the same.
    Type: Grant
    Filed: March 14, 2005
    Date of Patent: June 28, 2011
    Assignee: Sunesis Pharmaceuticals, Inc.
    Inventors: Michelle Arkin, Jennifer Hyde, Duncan Walker, Jasmin Wright