Abstract: The present disclosure relates a biocompatible biodegradable polymer matrix which serves as a template for the growth of differentiated skin tissue comprising a dermis and an epidermis, the combination of the matrix and the differentiated skin, the method of preparing the same and the tissue obtainable from said method. The disclosure also extends to use of the differentiated skin in treatment. Thus, there is provided a matrix of electrospun fibres for growing differentiated skin tissue prepared by electrospinning solution of a biocompatible biodegradable polymer, wherein the electrospun fibres are about 0.3 ?m to about 5 ?m in diameter for example 1 to 5 ?m, such as 1, 1.5, 2, 2.5, 3, 3.5, 4, or 4.