Abstract: Personalized mRNA cancer vaccines, as well as methods for their optimization and for their use in subjects are provided. In some embodiments, personalized mRNA cancer vaccines and their uses are provided for subjects having particular characteristics, e.g., the presence of certain biomarkers.

Abstract: Example embodiments relate to a system to generate and cause display of a specially configured graphical user interface to receive and present collections of images. According to certain example embodiments, an image analysis system: receives an image file from a client device; generates a hash value based on the image file; performs a comparison of the hash value with a list that comprises a collection of hash values; identifies a match to the hash value among the collection of hash values; assigns a label to the image file in response to identifying the match among the collection of image files from the list; and indexes the image file at a memory location identified by the label assigned to the image file.

Abstract: The present invention provides methods of dosing and administration of an activatable anti-CTLA-4 antibody, such as an activatable ipilimumab.

Abstract: Example embodiments relate to a system to generate and cause display of a specially configured graphical user interface to receive and present collections of images. According to certain example embodiments, an image analysis system: receives an image file from a client device; generates a hash value based on the image file; performs a comparison of the hash value with a list that comprises a collection of hash values; identifies a match to the hash value among the collection of hash values; assigns a label to the image file in response to identifying the match among the collection of image files from the list; and indexes the image file at a memory location identified by the label assigned to the image file.

Abstract: Example embodiments relate to a system to generate and cause display of a specially configured graphical user interface to receive and present collections of images. According to certain example embodiments, an image analysis system: receives an image file from a client device; generates a hash value based on the image file; performs a comparison of the hash value with a list that comprises a collection of hash values; identifies a match to the hash value among the collection of hash values; assigns a label to the image file in response to identifying the match among the collection of image files from the list; and indexes the image file at a memory location identified by the label assigned to the image file.

Abstract: The vehicular carbon monoxide and volatile organic compounds alarm is configured for use with a vehicle. The vehicle is further defined with a passenger space. The vehicular carbon monoxide and volatile organic compounds alarm is maintained in the passenger space of the vehicle. The vehicular carbon monoxide and volatile organic compounds alarm is a sensor. The vehicular carbon monoxide and volatile organic compounds alarm monitors the concentration of carbon monoxide and volatile organic compounds in the air in the passenger space of the vehicle. The vehicular carbon monoxide and volatile organic compounds alarm generates a visible and audible alarm when the concentration of carbon monoxide and volatile organic compounds in the passenger space of the vehicle exceeds a predetermined level. The vehicular carbon monoxide and volatile organic compounds alarm comprises an operating circuit and a housing. The housing contains the operating circuit.

Abstract: The vehicular carbon monoxide and volatile organic compounds alarm is configured for use with a vehicle. The vehicle is further defined with a passenger space. The vehicular carbon monoxide and volatile organic compounds alarm is maintained in the passenger space of the vehicle. The vehicular carbon monoxide and volatile organic compounds alarm is a sensor. The vehicular carbon monoxide and volatile organic compounds alarm monitors the concentration of carbon monoxide and volatile organic compounds in the air in the passenger space of the vehicle. The vehicular carbon monoxide and volatile organic compounds alarm generates a visible and audible alarm when the concentration of carbon monoxide and volatile organic compounds in the passenger space of the vehicle exceeds a predetermined level. The vehicular carbon monoxide and volatile organic compounds alarm comprises an operating circuit and a housing. The housing contains the operating circuit.

Abstract: This is specially designed clothing for autistic children. It may however also be used for children or adults who are physically or mentally infirm and provides a means to secure the clothing and provide a means to shorten the clothing.

Abstract: A weight for placement on a hand-held tool that has an elongated body portion. The weight has a generally cylindrical body defining a through-hole that is larger in diameter than the elongated body portion of the tool, and at least one flexible member coupled to the body and extending inwardly from the ends of the body such that it effectively decreases the through-hole diameter. The body and flexible member combination is placed onto the tool such that the elongated body portion of the tool protrudes from both ends of the body, with the flexible member frictionally engaging the elongated body portion.