Patents by Inventor Michelle Brownlow

Michelle Brownlow has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Optimized expression of hpv 58 l1 in yeast
    Publication number: 20070036824
    Abstract: Synthetic DNA molecules encoding the HPV58 L1 protein are provided. Specifically, the present invention provides polynucleotides encoding HPV58 L1 protein, wherein said polynucleotides are codon-optimized for high level expression in a yeast cell. The synthetic molecules may be used to produce HPV58 virus-like particles (VLPs), and to produce vaccines and pharmaceutical compositions comprising the HPV58 VLPs. The vaccines of the present invention provide effective imnunoprophylaxis against papillomavirus infection through neutralizing antibody and cell-mediated immunity and are also useful for treatment of existing HPV infections.
    Type: Application
    Filed: November 10, 2004
    Publication date: February 15, 2007
    Applicant: MERCK & CO., INC.
    Inventors: Janine Bryan, Michelle Brownlow, Loren Schultz, Xin-Min Wang, Kathrin Jansen
  • Optimized expression of hpv 45 l1 in yeast
    Publication number: 20060240040
    Abstract: Synthetic DNA molecules encoding the HPV45 L1 protein are provided. Specifically, the present invention provides polynucleotides encoding HPV45 L1 protein, wherein said polynucleotides have been codon-optimized for high level expression in a yeast cell. The synthetic molecules may be used to produce HPV45 virus-like particles (VLPs), and to produce vaccines and pharmaceutical compositions comprising the HPV45 VLPs. The vaccines of the present invention provide effective immunoprophylaxis against papillomavirus infection through neutralizing antibody and cell-mediated immunity.
    Type: Application
    Filed: September 24, 2004
    Publication date: October 26, 2006
    Inventors: Janine Bryan, Michelle Brownlow, Loren Schultz, Kathrin Jansen