Abstract: Methods for making surgical implants (or grafts) for the repair of bone defects, and more particularly, surgical implants that include demineralized bone fibers and mineralized bone pieces, are disclosed. Also disclosed are methods for increasing the wettability and ensuring uniform density of such implants. The surgical implants have a wettability time of less than 5 minutes, a residual moisture content of less than 6% by weight, and a complete rehydration time of less than about 30 minutes. The implants remain cohesive and retain their shape upon complete rehydration, and may be reshaped to a second shape which is retained until reshaped by external force.

Abstract: Methods for making surgical implants (or grafts) comprising tissue-derived pieces derived from cartilage, dermis, placenta, and combinations thereof, and which are shaped using a container or mold, or by compressing the tissue-derived pieces, into a first shape, including but not limited to a cylinder, a plug, or a sheet, and possibly also a secondary shape such as when the first shape is a sheet. Prior to shaping the tissue-derived pieces have one or more physical forms selected from fibers, flakes, particles, and powder. The implants are at least partially crosslinked by exposure to UV radiation, whereby the implants retain the first shape, as well as the secondary shape when present, when rehydrated, when compressed or subjected to cyclical loading. The implants stay in one piece and do not disperse when subjected to a load, during and after rehydration, during irrigation, or when placed in an aqueous environment.

Abstract: Methods for making surgical implants (or grafts) for the repair of bone defects, and more particularly, surgical implants that include demineralized bone fibers, are disclosed. Also disclosed are methods for increasing the wettability and ensuring uniform density of such implants. The surgical implants have a wettability time of less than 5 minutes and a residual moisture content of less than 6% by weight, and they remain cohesive and retain their shape upon complete rehydration.

Abstract: Methods for making surgical implants (or grafts) for the repair of bone defects, and more particularly, surgical implants that include demineralized bone fibers, are disclosed. Also disclosed are methods for increasing the wettability and ensuring uniform density of such implants. The surgical implants have a wettability time of less than 5 minutes and a residual moisture content of less than 6% by weight, and they remain cohesive and retain their shape upon complete rehydration.

Abstract: Methods for making surgical implants (or grafts) for the repair of bone defects, and more particularly, surgical implants that include demineralized bone fibers, are disclosed. Also disclosed are methods for increasing the wettability and ensuring uniform density of such implants. The surgical implants have a wettability time of less than 5 minutes and a residual moisture content of less than 6% by weight, and they remain cohesive and retain their shape upon complete rehydration.

Abstract: Methods for making surgical implants (or grafts) for the repair of bone defects, and more particularly, surgical implants that include demineralized bone fibers, are disclosed. Also disclosed are methods for increasing the wettability and ensuring uniform density of such implants. The surgical implants have a wettability time of less than 5 minutes and a residual moisture content of less than 6% by weight, and they remain cohesive and retain their shape upon complete rehydration.

Abstract: Surgical implants (or grafts) for the repair of bone defects, more particularly, surgical implants that include demineralized bone fibers, are disclosed. The surgical implants have a wettability time of less than 5 minutes and a residual moisture content of less than 6% by weight, and they remain cohesive and retain their shape upon complete rehydration. Methods for making such implants and for increasing their wettability and ensuring uniform density are also disclosed.

Abstract: Surgical grafts for the repair of bone defects, more particularly, surgical grafts that include demineralized bone fibers, are disclosed. Methods for making such grafts and for increasing their wettability and ensuring uniform density are also disclosed.