Patents by Inventor Michelle BUSCH

Michelle BUSCH has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for absolute quantification of low-abundance polypeptides using mass spectrometry
    Patent number: 11835434
    Abstract: The present invention provides methods for improved label-free absolute quantification of relatively low abundant polypeptides by liquid chromatography/mass spectrometry analysis of peptide products obtained from simple or complex polypeptide mixtures. The methods for absolute quantification include MS signals from a set of qualified ions of peptide products of a relatively high abundant polypeptide to improve quantification of a relatively low abundant polypeptide.
    Type: Grant
    Filed: December 17, 2020
    Date of Patent: December 5, 2023
    Assignee: Genzyme Corporation
    Inventors: Martha Stapels, Michelle Busch
  • METHODS FOR ABSOLUTE QUANTIFICATION OF LOW-ABUNDANCE POLYPEPTIDES USING MASS SPECTROMETRY
    Publication number: 20210102952
    Abstract: The present invention provides methods for improved label-free absolute quantification of relatively low abundant polypeptides by liquid chromatography/mass spectrometry analysis of peptide products obtained from simple or complex polypeptide mixtures. The methods for absolute quantification include MS signals from a set of qualified ions of peptide products of a relatively high abundant polypeptide to improve quantification of a relatively low abundant polypeptide.
    Type: Application
    Filed: December 17, 2020
    Publication date: April 8, 2021
    Inventors: Martha STAPELS, Michelle BUSCH
  • Methods for absolute quantification of low-abundance polypeptides using mass spectrometry
    Patent number: 10900972
    Abstract: The present invention provides methods for improved label-free absolute quantification of relatively low abundant polypeptides by liquid chromatography/mass spectrometry analysis of peptide products obtained from simple or complex polypeptide mixtures. The methods for absolute quantification include MS signals from a set of qualified ions of peptide products of a relatively high abundant polypeptide to improve quantification of a relatively low abundant polypeptide.
    Type: Grant
    Filed: June 1, 2018
    Date of Patent: January 26, 2021
    Assignee: GENZYME CORPORATION
    Inventors: Martha Stapels, Michelle Busch
  • METHODS FOR ABSOLUTE QUANTIFICATION OF LOW-ABUNDANCE POLYPEPTIDES USING MASS SPECTROMETRY
    Publication number: 20190004059
    Abstract: The present invention provides methods for improved label-free absolute quantification of relatively low abundant polypeptides by liquid chromatography/mass spectrometry analysis of peptide products obtained from simple or complex polypeptide mixtures. The methods for absolute quantification include MS signals from a set of qualified ions of peptide products of a relatively high abundant polypeptide to improve quantification of a relatively low abundant polypeptide.
    Type: Application
    Filed: June 1, 2018
    Publication date: January 3, 2019
    Inventors: Martha STAPELS, Michelle BUSCH