Abstract: Described herein is a method for producing photochromic silicone hydrogel contact lenses in a relatively efficient and consistent manner from a polymerizable composition under a controlled thermal curing scheme. The main polymerizable components in the polymerizable composition are a high radical-reactive hydrophilic (meth)acrylamido monomer, a high radical-reactive siloxane-containing (meth)acrylamido monomer, and a polysiloxane vinylic crosslinker(s) free of low-reactive ethylenically unsaturated group as the main crosslinker. The thermal free radical initiator having a 10 hour half-life temperature (T10h?) of from about 50° C. to about 90° C. The controlled thermal curing scheme includes maintaining a first curing temperature of from about (T10h??20)° C. to about T10h?° C. for a first curing time and maintaining a second curing temperature of from about (T10h?+10)° C. to about (T10h?+35)° C. for a second curing time.

Abstract: Disclosed herein are methods of generating proteoglycans with distinct glycan structures in engineered, non-naturally occurring eukaryotic cells. These methods make accessible a dynamic range of protein glycosylation. Compositions of engineered, non-naturally occurring cells capable of generating these proteoglycans are also disclosed herein.

Abstract: This invention is a novel method for tactile printing which comprises of a low power energy source to heat temperature sensitive elements within a medium such as microcapsule paper.

Abstract: Computer-based methods and systems perform root cause analysis with the construction of a probabilistic graph model (PGM) that explains the, e.g., negative, event dynamics of a processing plant, demonstrates precursor profiles for real-time monitoring, and provides probabilistic prediction of plant event occurrence based on real-time data. The methods and systems establish causal relationships between processing events in the upstream and resulting events in the downstream sensor data. The methods and systems provide early warnings for online process monitoring in order to prevent undesired events. The methods and systems successfully combine historical time series data with PGM analysis for operational diagnosis and prevention in order to identify the root cause of one or more events in the midst of multitude of continuously occurring events.

Abstract: A laser-marking machine comprising a main body, a beam splitter, a plurality of transmitting lines and a plurality of scanheads, wherein the main body has a laser head for producing laser light, the beam splitter is connected with the laser head on the main body, thereby laser light can be split by the beam splitter, one end of each of the transmitting lines is connected to the beam splitter, while the other end of each of the transmitting lines is connected to a corresponding one of the scanheads, thereby the laser light split by the beam splitter can be transmitted to each scanhead through each corresponding one of the transmitting lines.