Patents by Inventor Michelle Chia-Yu Chang

Michelle Chia-Yu Chang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Artemisinic epoxide and methods for producing same
    Patent number: 8101399
    Abstract: The present invention provides artemisinic epoxide, and methods of synthesizing artemisinic epoxide in a genetically modified host cell. The present invention further provides methods for producing artemisinin. The present invention further provides variant enzymes that catalyze the oxidation of amorpha-4,11-diene to artemisinic epoxide; nucleic acids encoding the variant enzymes; as well as recombinant vectors and host cells comprising the nucleic acids.
    Type: Grant
    Filed: December 12, 2007
    Date of Patent: January 24, 2012
    Assignee: The Regents of the University of California
    Inventors: Jeffrey Allen Dietrich, Yasuo Yoshikuni, Jay D. Keasling, Michelle Chia-Yu Chang
  • Nucleic acids encoding modified cytochrome P450 enzymes and methods of use thereof
    Patent number: 8097438
    Abstract: The present invention provides nucleic acids comprising nucleotide sequences encoding modified cytochrome P450 enzymes; as well as recombinant vectors and host cells comprising the nucleic acids. The present invention further provides methods of producing a functionalized compound in a host cell genetically modified with a nucleic acid comprising nucleotide sequences encoding a modified cytochrome P450 enzyme.
    Type: Grant
    Filed: October 5, 2006
    Date of Patent: January 17, 2012
    Assignee: The Regents of the University of California
    Inventors: Michelle Chia-Yu Chang, Rachel A. Krupa, Dae-Kyun Ro, Yasuo Yoshikuni, Jay D. Keasling
  • NUCLEIC ACIDS ENCODING MODIFIED CYTOCHROME P450 ENZYMES AND METHODS OF USE THEREOF
    Publication number: 20090098626
    Abstract: The present invention provides nucleic acids comprising nucleotide sequences encoding modified cytochrome P450 enzymes; as well as recombinant vectors and host cells comprising the nucleic acids. The present invention further provides methods of producing a functionalized compound in a host cell genetically modified with a nucleic acid comprising nucleotide sequences encoding a modified cytochrome P450 enzyme.
    Type: Application
    Filed: October 5, 2006
    Publication date: April 16, 2009
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Michelle Chia-Yu Chang, Rachel A. Krupa, Dae-Kyun Ro, Yasuo Yoshikuni, Jay D. Keasling
  • GENETICALLY MODIFIED HOST CELLS FOR INCREASED P450 ACTIVITY LEVELS AND METHODS OF USE THEREOF
    Publication number: 20080233623
    Abstract: The present invention provides genetically modified host cells that exhibit modified activity levels of one or more gene products such that, when a cytochrome P450 enzyme is produced in the genetically modified host cell, the modified activity levels of the one or more gene products provide for enhanced production and/or activity of the cytochrome P450 enzyme. The present invention provides methods of producing a cytochrome P450 enzyme in a host cell, generally involving culturing a subject genetically modified host cell in a suitable culture medium. The present invention further provides methods of producing a product of a P450-dependent oxidation, generally involving culturing a subject genetically modified host cell in a suitable culture medium.
    Type: Application
    Filed: January 29, 2008
    Publication date: September 25, 2008
    Inventors: Michelle Chia-Yu Chang, Rachel A. Krupa, Jeffrey Lance Kizer, John R. Haliburton, Mario Ouellet, Jeffrey Alan Dietrich, Jay D. Keasling
  • ARTEMISINIC EPOXIDE AND METHODS FOR PRODUCING SAME
    Publication number: 20080187983
    Abstract: The present invention provides artemisinic epoxide, and methods of synthesizing artemisinic epoxide in a genetically modified host cell. The present invention further provides methods for producing artemisinin. The present invention further provides variant enzymes that catalyze the oxidation of amorpha-4,11-diene to artemisinic epoxide; nucleic acids encoding the variant enzymes; as well as recombinant vectors and host cells comprising the nucleic acids.
    Type: Application
    Filed: December 12, 2007
    Publication date: August 7, 2008
    Inventors: Jeffrey Allen DIETRICH, Yasuo Yoshikuni, Jay D. Keasling, Michelle Chia-Yu Chang