Patents by Inventor Michelle D. Butler

Michelle D. Butler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Recombinant production of vascular endothelial growth factor
    Patent number: 8906648
    Abstract: A process for recovering and purifying refolded heparin binding proteins produced in heterologous host cells includes the step of incubation of the solubilized protein with a polyanionic species such as dextran sulfate.
    Type: Grant
    Filed: March 26, 2013
    Date of Patent: December 9, 2014
    Assignee: Genentech, Inc.
    Inventors: Michelle D. Butler, Jeffrey L. Cleland, David W. Kahn, Shelly Pizarro, Charles H. Schmelzer, Marjorie E. Winkler
  • Recombinant Production of Heparin Binding Proteins
    Publication number: 20100261888
    Abstract: A process for recovering and purifying refolded heparin binding proteins produced in heterologous host cells includes the step of incubation of the solubilized protein with a polyanionic species such as dextran sulfate.
    Type: Application
    Filed: June 17, 2010
    Publication date: October 14, 2010
    Applicant: Genentech, Inc.
    Inventors: Michelle D. Butler, Jeffrey L. Cleland, David W. Kahn, Shelly Pizarro, Charles H. Schmelzer, Marjorie E. Winkler
  • Purification of plasmid DNA
    Patent number: 6313285
    Abstract: A process is described for purifying plasmid DNA from prokaryotic cells comprised thereof. This process comprises the steps of: (a) digesting the cells; (b) incubating the cells for about 4 to 24 hours to effect lysis and solubilization thereof, without effecting enzymatic digestion of RNA; (c) removing lysate contaminants from the cells to provide a plasmid DNA solution; (d) filtering the solution through a tangential flow filtration device to obtain a retentate containing the plasmid DNA; and (e) collecting the retentate.
    Type: Grant
    Filed: July 21, 2000
    Date of Patent: November 6, 2001
    Assignee: Genentech, Inc.
    Inventors: Michelle D. Butler, Darien L. Cohen, David Kahn, Marjorie E. Winkler