Abstract: The present invention relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, intermediates thereto, and uses thereof. QS-7 is a potent immuno-adjuvant that is significantly less toxic than QS-21, a related saponin that is currently the favored adjuvant in anticancer and antiviral vaccines. Tedious isolation and purification protocols have hindered the clinical development of QS-7. A novel semi-synthetic method is provided wherein a hydrolyzed prosapogenin mixture is used to synthesize QS-7, QS-21, and related analogs, greatly facilitating access to QS-7 and QS-21 analogs for preclinical and clinical evaluation.

Abstract: Described herein are multicistronic expression systems that encode chimeric proteins, specifically membrane-cleavable chimeric systems and chimeric antigen receptors. Also described herein are nucleic acids, cells, and methods directed to the same.

Abstract: A housing and flange assembly arrangement for a breast pump system including or involving a flange having transparent and other structure for facilitating alignment of the breast pump on a breast, and includes structure facilitating ease of assembly of a housing for the breast pump.

Abstract: Methods, systems, and apparatuses for sidelink communication are disclosed. A WTRU may receive a first SCI element from a second WTRU within a group. The WTRU may receive a first RCI element within a first set of resources scheduled by the first SCI. The first RCI may include information about which WTRU in the group is scheduled to use a second set of resources. The WTRU may determine, based on the first RCI, that one or more subresources within the second set of resources are available. The WTRU may transmit data in the one or more subresources. The first SCI and the first RCI may be received in a first reservation period and the one or more subresources may be in a second reservation period.

Abstract: A housing and flange assembly arrangement for a breast pump system including or involving a flange having transparent and other structure for facilitating alignment of the breast pump on a breast, and includes structure facilitating ease of assembly of a housing for the breast pump.

Abstract: A multi-lead introducer for facilitating implantation of stimulation leads includes a needle assembly for concurrently implanting multiple leads into a patient. The needle assembly includes a first needle with a first needle lumen configured to receive a first lead. A first sharpened tip is disposed along a first end of the first needle for piercing patient tissue. A second needle defines a second needle lumen configured to receive a second lead. A second sharpened tip is disposed along a first end of the second needle for piercing patient tissue. A hub is coupled to second ends of both the first needle and the second needle. The hub defines a hub lumen that is in communication with both the first needle lumen and the second needle lumen. The hub lumen is configured to concurrently receive both the first lead and the second lead.