Abstract: Gastric residence systems for administration of agents, such as drugs, are disclosed. Features which enhance gastric retention during the desired residence time and which allow for more precise control over residence time are disclosed, including circumferential filaments connecting the arms of a stellate gastric residence system; flexible arms for a gastric residence system; improved time-dependent and enteric disintegrating matrices (linkers); and release rate-modulating polymer coatings which are resistant to change in release rate properties during heat-assisted assembly or thermal cycling. Combinations of these features are also disclosed.

Abstract: A deflector is attached to a frame on a vehicle in front of a front wheel which cooperates with the front wheel to glance a vehicle past a laterally offset impacting object. The deflector acts as a first boundary against the impacting object and the deflector turns the front wheel inboard to an inwardly turned position to act as a second deflecting boundary against the impacting object. The deflector and inwardly turned front wheel cooperate to deflect the vehicle past the object, such that the object passes outboard of a rocker member on the vehicle.