Patents by Inventor Michelle E. Hung

Michelle E. Hung has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TARGETED EXTRACELLULAR VESICLES COMPRISING MEMBRANE PROTEINS WITH ENGINEERED GLYCOSYLATION SITES
    Publication number: 20240342087
    Abstract: Disclosed are extracellular vesicles comprising an engineered targeting protein for targeting the extracellular vesicles to target cells. The targeting protein is a fusion protein that includes a ligand, an engineered glycosylation site, and an exosome-targeting domain. Exemplary extracellular vesicles may include but are not limited to exosomes.
    Type: Application
    Filed: June 3, 2024
    Publication date: October 17, 2024
    Applicant: Northwestern University
    Inventors: Joshua N. Leonard, Michelle E. Hung
  • Targeted extracellular vesicles comprising membrane proteins with engineered glycosylation sites
    Patent number: 11998635
    Abstract: Disclosed are extracellular vesicles comprising an engineered targeting protein for targeting the extracellular vesicles to target cells. The targeting protein is a fusion protein that includes a ligand, an engineered glycosylation site, and an exosome-targeting domain. Exemplary extracellular vesicles may include but are not limited to exosomes.
    Type: Grant
    Filed: April 20, 2020
    Date of Patent: June 4, 2024
    Assignee: Northwestern University
    Inventors: Joshua N. Leonard, Michelle E. Hung
  • TARGETED EXTRACELLULAR VESICLES COMPRISING MEMBRANE PROTEINS WITH ENGINEERED GLYCOSYLATION SITES
    Publication number: 20200390700
    Abstract: Disclosed are extracellular vesicles comprising an engineered targeting protein for targeting the extracellular vesicles to target cells. The targeting protein is a fusion protein that includes a ligand, an engineered glycosylation site, and an exosome-targeting domain. Exemplary extracellular vesicles may include but are not limited to exosomes.
    Type: Application
    Filed: April 20, 2020
    Publication date: December 17, 2020
    Applicant: Northwestern University
    Inventors: Joshua N. Leonard, Michelle E. Hung
  • TARGETED AND MODULAR EXOSOME LOADING SYSTEM
    Publication number: 20200317746
    Abstract: Disclosed are exosomes that include a packaging protein and a cargo RNA in which the packaging protein binds specifically to the cargo RNA. The packaging protein is a fusion protein that includes an RNA-binding domain and an exosome-targeting domain. The cargo RNA includes an RNA-motif that the RNA-binding domain of the fusion protein binds specifically such that the cargo RNA is packaged in the lumen of the exosomes.
    Type: Application
    Filed: January 17, 2020
    Publication date: October 8, 2020
    Applicant: NORTHWESTERN UNIVERSITY
    Inventors: Joshua N. Leonard, Michelle E. Hung
  • Targeted extracellular vesicles comprising membrane proteins with engineered glycosylation sites
    Patent number: 10624849
    Abstract: Disclosed are extracellular vesicles comprising an engineered targeting protein for targeting the extracellular vesicles to target cells. The targeting protein is a fusion protein that includes a ligand, an engineered glycosylation site, and an exosome-targeting domain. Exemplary extracellular vesicles may include but are not limited to exosomes.
    Type: Grant
    Filed: September 28, 2016
    Date of Patent: April 21, 2020
    Assignee: Northwestern University
    Inventors: Joshua N. Leonard, Michelle E. Hung
  • Targeted and modular exosome loading system
    Patent number: 10538570
    Abstract: Disclosed are exosomes that include a packaging protein and a cargo RNA in which the packaging protein binds specifically to the cargo RNA. The packaging protein is a fusion protein that includes an RNA-binding domain and an exosome-targeting domain. The cargo RNA includes an RNA-motif that the RNA-binding domain of the fusion protein binds specifically such that the cargo RNA is packaged in the lumen of the exosomes.
    Type: Grant
    Filed: September 30, 2014
    Date of Patent: January 21, 2020
    Assignee: Northwestern University
    Inventors: Joshua N. Leonard, Michelle E. Hung
  • TARGETED EXTRACELLULAR VESICLES COMPRISING MEMBRANE PROTEINS WITH ENGINEERED GLYCOSYLATION SITES
    Publication number: 20170087087
    Abstract: Disclosed are extracellular vesicles comprising an engineered targeting protein for targeting the extracellular vesicles to target cells. The targeting protein is a fusion protein that includes a ligand, an engineered glycosylation site, and an exosome-targeting domain. Exemplary extracellular vesicles may include but are not limited to exosomes.
    Type: Application
    Filed: September 28, 2016
    Publication date: March 30, 2017
    Applicant: Northwestern University
    Inventors: Joshua N. Leonard, Michelle E. Hung