Patents by Inventor Michelle E. Pizzo

Michelle E. Pizzo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Osmotic enhancement of drug/therapeutic delivery to the brain following infusion or injection into the cerebrospinal fluid
    Patent number: 10123969
    Abstract: A method of enhancing therapeutic/drug transport to the perivascular space of the brain of a patient is disclosed. In one embodiment, the method comprises the step of introducing a therapeutic/drug and an osmolyte of the present invention into a patient's cerebrospinal fluid (CSF), wherein the osmolyte is introduced to the CSF at a concentration of between 0.5 and 12.9 M (dependent on the solubility upper limit of the osmolyte), and wherein the therapeutic/drug delivery to the perivascular spaces of cerebral blood vessels and parenchyma of the central nervous system is facilitated by the presence of the osmolyte.
    Type: Grant
    Filed: October 14, 2016
    Date of Patent: November 13, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Robert G. Thorne, Michelle E. Pizzo, Daniel J. Wolak
  • OSMOTIC ENHANCEMENT OF DRUG/THERAPEUTIC DELIVERY TO THE BRAIN FOLLOWING INFUSION OR INJECTION INTO THE CEREBROSPINAL FLUID
    Publication number: 20170105927
    Abstract: A method of enhancing therapeutic/drug transport to the perivascular space of the brain of a patient is disclosed. In one embodiment, the method comprises the step of introducing a therapeutic/drug and an osmolyte of the present invention into a patient's cerebrospinal fluid (CSF), wherein the osmolyte is introduced to the CSF at a concentration of between 0.5 and 12.9 M (dependent on the solubility upper limit of the osmolyte), and wherein the therapeutic/drug delivery to the perivascular spaces of cerebral blood vessels and parenchyma of the central nervous system is facilitated by the presence of the osmolyte.
    Type: Application
    Filed: October 14, 2016
    Publication date: April 20, 2017
    Inventors: Robert G. Thorne, Michelle E. Pizzo, Daniel J. Wolak