Abstract: A stent having an inner surface and an outer surface, the stent comprising a coating composition comprising a platelet-activated adhesive on at least a portion of the outer surface thereof.

Abstract: A stent having an inner surface and an outer surface, the stent comprising a coating composition comprising a platelet-activated adhesive on at least a portion of the outer surface thereof.

Abstract: A stent having an inner surface and an outer surface, the stent comprising a coating composition comprising a platelet-activated adhesive on at least a portion of the outer surface thereof.

Abstract: A stent having an inner surface and an outer surface, the stent comprising a coating composition comprising a platelet-activated adhesive on at least a portion of the outer surface thereof.

Abstract: A device for causing hemostasis includes a sheet of mesh stretchable between an expanded and a retracted configuration, a size of the sheet in the retracted configuration being selected to cover a target tissue site; a spring mechanism coupled to the mesh, the spring mechanism moving between an expanded configuration and a retracted configuration when the mesh is moved between the expanded and retracted configurations; and a plurality of hooks coupled to the mesh and oriented to extend into tissue to lock the mesh in position when the mesh is placed in a desired position over the target tissue site in the expanded configuration. The hooks are lockingly engaging the target tissue so that, after the hooks have lockingly engaged the tissue, the spring mechanism reverts to the retracted configuration drawing the engaged portions of tissue radially inward.

Abstract: A tissue closure device includes a first clip including a first longitudinal element extending along a longitudinal axis from a proximal end to a distal end and a first pair of arms extending laterally from the first longitudinal element, the first pair of arms movable between an open configuration in which free ends of the first pair of arms are separated from one another and a closed configuration in which the free ends of the first pair of arms extend toward one another, the first pair of arms being biased toward the closed configuration, and a sliding element extending from a proximal end to a distal end and longitudinally movable relative to the first clip so that when a portion of the sliding element is received between the first pair of arms, the first pair of arms is moved from the biased closed configuration to the open configuration.

Abstract: A stent having an inner surface and an outer surface, the stent comprising a coating composition comprising a platelet-activated adhesive on at least a portion of the outer surface thereof.

Abstract: A stent having an inner surface and an outer surface, the stent comprising a coating composition comprising a platelet-activated adhesive on at least a portion of the outer surface thereof.

Abstract: A device for treating tissue includes a helical needle extending about a longitudinal axis thereof from a distal tip to a proximal end and a control member extending longitudinally between a distal end releasably coupled to the proximal end of the helical needle and a proximal end which, when the helical needle is inserted into a body, remains outside the body, the control member configured such that rotation of the control member about the longitudinal axis rotates the helical needle to screw the helical needle distally into a target tissue.

Abstract: Embodiments of the disclosure relate to devices, systems and methods of use and manufacture. One such device is a stent. The stent includes a stent body and a coating over at least a portion of the stent body. The coating includes a shape memory polymer having an outer surface. The outer surface defines a first configuration and a second configuration. In the first configuration the outer surface is smooth. In the second configuration, the outer surface includes a micro pattern.

Abstract: A tissue closure device includes a first clip including a first longitudinal element extending along a longitudinal axis from a proximal end to a distal end and a first pair of arms extending laterally from the first longitudinal element, the first pair of arms movable between an open configuration in which free ends of the first pair of arms are separated from one another and a closed configuration in which the free ends of the first pair of arms extend toward one another, the first pair of arms being biased toward the closed configuration, and a sliding element extending from a proximal end to a distal end and longitudinally movable relative to the first clip so that when a portion of the sliding element is received between the first pair of arms, the first pair of arms is moved from the biased closed configuration to the open configuration.

Abstract: The present disclosure pertain to methods of tissue approximation of a tissue opening in a tissue wall of a body lumen. The method comprises pushing a suitable device through the tissue wall near at least one edge of the opening and pulling opposing edges of the tissue opening nearer to one another or into contact with one another. Also described are devices and kits that are useful for approximation of a tissue opening in a tissue wall of a body lumen.

Abstract: A stent having an inner surface and an outer surface, the stent comprising a coating composition comprising a platelet-activated adhesive on at least a portion of the outer surface thereof.

Abstract: A device for causing hemostasis includes a sheet of mesh stretchable between an expanded and a retracted configuration, a size of the sheet in the retracted configuration being selected to cover a target tissue site; a spring mechanism coupled to the mesh, the spring mechanism moving between an expanded configuration and a retracted configuration when the mesh is moved between the expanded and retracted configurations; and a plurality of hooks coupled to the mesh and oriented to extend into tissue to lock the mesh in position when the mesh is placed in a desired position over the target tissue site in the expanded configuration. The hooks are lockingly engaging the target tissue so that, after the hooks have lockingly engaged the tissue, the spring mechanism reverts to the retracted configuration drawing the engaged portions of tissue radially inward.