Patents by Inventor Michelle FLEURY

Michelle FLEURY has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CA2-IL15 fusion proteins for tunable regulation
    Patent number: 12642792
    Abstract: The present disclosure provides drug responsive domains derived from human carbonic anhydrase 2 that can modulate protein stability for human interleukin 15 (IL15) payloads, as well as compositions and methods of use thereof.
    Type: Grant
    Filed: September 10, 2020
    Date of Patent: June 2, 2026
    Assignee: OBSIDIAN THERAPEUTICS, INC.
    Inventors: Kutlu Goksu Elpek, Dhruv Kam Sethi, Meghan C. Langley, Tucker Read Ezell, Dexue Sun, Jennifer Leah Gori, Geetha Hanna Mylvaganam, Michelle Ols, Michelle Fleury, Celeste Richardson, James A. Storer, Vipin Suri, Shyamsundar Subramanian, Colleen Foley, Molly Reed Perkins, Jeremy Hatem Tchaicha, Scott Francis Heller
  • COMPOSITIONS AND METHODS FOR TCR REPROGRAMMING USING FUSION PROTEINS
    Publication number: 20240117002
    Abstract: Provided herein are recombinant nucleic acids encoding a T cell receptor (TCR) fusion protein (TFP) and an interleukin-15 (IL-15) polypeptide and/or an interleukin-15 receptor alpha (IL-15R?) polypeptide, modified T cells expressing the encoded molecules, and methods of use thereof for the treatment of diseases, including cancer.
    Type: Application
    Filed: December 23, 2021
    Publication date: April 11, 2024
    Inventors: Robert TIGHE, Pooja ARORA, Robert HOFMEISTER, Dario GUTIERREZ, Derrick MCCARTHY, Michelle FLEURY
  • CA2-IL15 FUSION PROTEINS FOR TUNABLE REGULATION
    Publication number: 20220332780
    Abstract: The present disclosure provides drug responsive domains derived from human carbonic anhydrase 2 that can modulate protein stability for human interleukin 15 (EL15) payloads, as well as compositions and methods of use thereof.
    Type: Application
    Filed: September 10, 2020
    Publication date: October 20, 2022
    Inventors: Kutlu Goksu ELPEK, Dhruv Kam SETHI, Meghan C. LANGLEY, Tucker Read EZELL, Dexue SUN, Jennifer Leah GORI, Geetha Hanna MYLVAGANAM, Michelle OLS, Michelle FLEURY, Celeste RICHARDSON, James A. STORER, Vipin SURI, Shyamsundar SUBRAMANIAN, Colleen FOLEY, Molly Reed PERKINS, Jeremy Hatem TCHAICHA, Scott Francis HELLER
  • CA2 compositions and methods for tunable regulation
    Patent number: 11058725
    Abstract: The present disclosure provides drug responsive domains derived from human carbonic anhydrase 2 that can modulate protein stability for human interleukin 15 (IL15) payloads, as well as compositions and methods of use thereof.
    Type: Grant
    Filed: September 10, 2020
    Date of Patent: July 13, 2021
    Assignee: Obsidian Therapeutics, Inc.
    Inventors: Kutlu Goksu Elpek, Dhruv Kam Sethi, Meghan C. Langley, Tucker Read Ezell, Dexue Sun, Jennifer Leah Gori, Geetha Hanna Mylvaganam, Michelle Ols, Michelle Fleury, Celeste Richardson, James A. Storer, Vipin Suri, Shyamsundar Subramanian, Colleen Foley, Molly Reed Perkins, Jeremy Hatem Tchaicha, Scott Francis Heller
  • CA2 COMPOSITIONS AND METHODS FOR TUNABLE REGULATION
    Publication number: 20210069248
    Abstract: The present disclosure provides drug responsive domains derived from human carbonic anhydrase 2 that can modulate protein stability for human interleukin 15 (IL15) payloads, as well as compositions and methods of use thereof.
    Type: Application
    Filed: September 10, 2020
    Publication date: March 11, 2021
    Applicant: Obsidian Therapeutics, Inc.
    Inventors: Kutlu Goksu ELPEK, Meghan C. LANGLEY, Tucker Read EZELL, Dexue SUN, Jennifer Leah GORI, Geetha Hanna MYLVAGANAM, Michelle OLS, Michelle FLEURY, Celeste RICHARDSON, James A. STORER, Vipin SURI, Shyamsundar SUBRAMANIAN, Colleen FOLEY, Molly Reed PERKINS, Jeremy Hatem TCHAICHA, Scott Francis HELLER