Patents by Inventor Michelle H. Pauling

Michelle H. Pauling has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Human monoclonal antibody against coreceptors for human immunodeficiency virus
    Patent number: 7005503
    Abstract: Compositions are provided that comprise antibody against coreceptors for human immunodeficiency virus such as CCR5 and CXCR4. In particular, monoclonal human antibodies against human CCR5 are provided that bind to CCR5 with high affinity and are capable of inhibiting HIV infection at low concentrations. The antibodies can be used as prophylactics or therapeutics to prevent and treat HIV infection, for screening drugs, and for diagnosing diseases or conditions associated with interactions with HIV coreceptors.
    Type: Grant
    Filed: February 8, 2002
    Date of Patent: February 28, 2006
    Assignee: Genetastix Corporation
    Inventors: Shaobing Hua, Michelle H. Pauling, Li Zhu
  • High throughput generation of human monoclonal antibody against peptide fragments derived from membrane proteins
    Publication number: 20030165988
    Abstract: Methods are provided for efficient, high throughput screening of antibody libraries against proteins targets, especially membrane proteins. In particular, methods are provided for screening a fully human antibody library against membrane proteins such as HIV coreceptors in yeast. More particularly, a library of human single chain antibodies is screened against peptide fragments derived from extracellular domains of human CCR5 and high affinity monoclonal antibodies against CCR5 are selected.
    Type: Application
    Filed: February 8, 2002
    Publication date: September 4, 2003
    Inventors: Shaobing Hua, Michelle H. Pauling, Li Zhu
  • Human monoclonal antibody against coreceptors for human immunodeficiency virus
    Publication number: 20030152913
    Abstract: Compositions are provided that comprise antibody against coreceptors for human immunodeficiency virus such as CCR5 and CXCR4. In particular, monoclonal human antibodies against human CCR5 are provided that bind to CCR5 with high affinity and are capable of inhibiting HIV infection at low concentrations. The antibodies can be used as prophylactics or therapeutics to prevent and treat HIV infection, for screening drugs, and for diagnosing diseases or conditions associated with interactions with HIV coreceptors.
    Type: Application
    Filed: February 8, 2002
    Publication date: August 14, 2003
    Inventors: Shaobing Hua, Michelle H. Pauling, Li Zhu