Abstract: Provided herein are mutants of estrogen receptor alpha ligand binding domain (ER-LBD), and chimeric proteins including such mutant ER-LBD. Also provided are methods of modulating transcription and modulating localization of such chimeric proteins.

Abstract: A structural mount is used for attaching devices to a gutter. The mount includes a gutter engaging portion and a device engaging portion. The gutter engaging portion including two gutter mounts. The gutter mounts include a spiral hook and a stabilizer. The spiral hook extends above a gutter lip and into a gutter channel such that a proximal point of the spiral hook is positioned against an inner surface of a front wall of the gutter, and the stabilizer contacts an outer surface of the front wall of the gutter when the attachment device is engaged with the gutter. The device engaging portion includes a mounting surface and a mounting plate. The mounting plate is capable of receiving a securing clip attached to a device such that the device may engage with the mounting surface via the mounting plate and the securing clip.

Abstract: Systems and methods for adjusting operating parameters of at least one pipelined software asset. Within a pipelined environment, an agent software asset is inserted immediately preceding a software asset whose operating parameters are to be adjusted. The agent software asset receives data and/or data sets from a user and such data and data sets are inserted/used by the software asset. The agent software asset also allows for a reporting of the output of other software assets to thereby provide users with intermediate outputs from the pipelined environment.

Abstract: The present invention is directed to antibodies and antigen binding fragments thereof having binding specificity for PACAP. The antibodies and antigen binding fragments thereof comprise the sequences of the VH, VL, and CDR polypeptides described herein, and the polynucleotides encoding them. Antibodies and antigen binding fragments described herein bind to and/or compete for binding to the same linear or conformational epitope(s) on human PACAP as an anti-PACAP antibody. The invention contemplates conjugates of anti-PACAP antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. Methods of making said anti-PACAP antibodies and antigen binding fragments thereof are also contemplated.

Abstract: An absorbent article comprising an absorbent member positioned between a topsheet and a backsheet is provided. The absorbent member contains at least one layer that comprises porous superabsorbent particles, wherein the particles exhibit a relative humidity microclimate of about 67% or less after being exposed to an atmosphere having a temperature of about 23° C. and relative humidity of 80% for a time period of 20 minutes.

Abstract: Described herein are chimeric proteins, specifically membrane-cleavable chimeric systems. Also described herein are nucleic acids, cells, and methods directed to the same.

Abstract: An endoscopy system according to the present disclosure includes an adapter for coupling a mobile device to an endoscope. A guide can be included that enables proper alignment of the adapter with the mobile device so that a generally centered image is presented on the mobile device from the endoscope. Further, various embodiments of the adapter can include integrated optical lenses.

Abstract: A method for preparing a nutritional multi-supplement complex, the method comprising: (i) preparing a dispersion of spheroidal polysaccharide-stabilized complexes comprising a water-soluble polysaccharide and at least one water-soluble nutritional supplement in an aqueous medium, wherein the water-soluble polysaccharide and water-soluble nutritional supplement are complexed with each other by ionic interactions in the spheroidal polysaccharide-stabilized complexes; (ii) preparing an oil-supplement solution comprising at least one oil-soluble nutritional supplement dissolved in a food grade oil; and (iii) blending the dispersion of spheroidal polysaccharide-stabilized complexes with the oil-supplement solution to produce the nutritional multi-supplement complex, wherein the nutritional multi-supplement complex comprises droplets of the oil-supplement solution encapsulated by the spheroidal polysaccharide-stabilized complexes.

Abstract: In a method for generating at least one smart link, a plurality of destination digital resources is received. At least one smart link is generated based on the plurality of destination digital resources, wherein the at least one smart link provides configurable access to the plurality of destination digital resources in response to an interaction with the at least one smart link.

Abstract: In a method for generating at least one smart link, a plurality of destination digital resources is received. At least one smart link is generated based on the plurality of destination digital resources, wherein the at least one smart link provides configurable access to the plurality of destination digital resources in response to an interaction with the at least one smart link.

Abstract: A structural mount is used for attaching devices to a gutter. The mount includes a gutter engaging portion and a device engaging portion. The gutter engaging portion including two gutter mounts. The gutter mounts include a spiral hook and a stabilizer. The spiral hook extends above a gutter lip and into a gutter channel such that a proximal point of the spiral hook is positioned against an inner surface of a front wall of the gutter, and the stabilizer contacts an outer surface of the front wall of the gutter when the attachment device is engaged with the gutter. The device engaging portion includes a mounting surface and a mounting plate. The mounting plate is capable of receiving a securing clip attached to a device such that the device may engage with the mounting surface via the mounting plate and the securing clip.

Abstract: In a method for using a smart link to access a digital resource, a smart link access request is received from an electronic device interacting with a smart link, wherein a smart link provides access to at least one destination digital resource of a plurality of destination digital resources associated with the smart link. The at least one destination digital resource to access is determined based at least on the smart link access request. The electronic device is directed to the determined at least one destination digital resource.

Abstract: Various implementations include control mechanisms for managing hearing aid usage. In some cases, an interface with a representation of the hearing aid in space is used to control audio functions in the device. In other cases, directionality of the device is controlled based upon the user's visual focus direction. In additional cases, the operating mode of the device is adjustable based upon the signature of a nearby acoustic signal.

Abstract: Methods and compositions for evaluating the efficiency of chromosomal rearrangement are provided. In some examples, systems comprising a first DNA molecule comprising the N-terminal portion of a first split reporter coding sequence linked to the C-terminal portion of a second split reporter coding sequence via a first intron, and a second DNA molecule comprising the N-terminal portion of said second split reporter coding sequence linked to the C-terminal portion of said first split reporter coding sequence via a second intron. The introns comprise at least one target site recognized by a genome editing reagent, such as a recombinase or endonuclease, such that recombination results in expression of the first or second reporter coding sequence following splicing of the introns.

Abstract: In a method for using a smart link to access a digital resource, a smart link access request is received from an electronic device interacting with a smart link, wherein a smart link provides access to at least one destination digital resource of a plurality of destination digital resources associated with the smart link. The at least one destination digital resource to access is determined based at least on the smart link access request. The electronic device is directed to the determined at least one destination digital resource.

Abstract: In a computer-implemented method for generating a privacy compliant audit log for a conversational interface, a request for information from a user is received at a conversational interface. A response to the request for information is generated, the response including data responsive to the request for information. It is determined whether the response comprises private user data. An audit log including the request and information related to the response is generated, where the information related to the response does not include the private user data.

Abstract: In a method for generating at least one smart link, a plurality of destination digital resources is received. At least one smart link is generated based on the plurality of destination digital resources, wherein the at least one smart link provides configurable access to the plurality of destination digital resources in response to an interaction with the at least one smart link.