Abstract: This disclosure provides, e.g., novel cells having a modification (e.g., insertion or deletion) in the endogenous CD 123 gene. The disclosure also provides compositions, e.g., gRNAs, that can be used to make such a modification.

Abstract: This disclosure provides, e.g., novel cells having a modification (e.g., insertion or deletion) in the endogenous CLL1 gene. The disclosure also provides compositions, e.g., gRNAs, that can be used to make such a modification.

Abstract: Aspects of the disclosure provide methods and compositions for treating a hematopoietic malignancy (e.g., acute myeloid leukemia). In some aspects, the disclosure provides methods of treatment using a population of genetically engineered CD33-deficient hematopoietic cells and a cytotoxic agent comprising an anti-CD33 antigen-binding domain.

Abstract: The disclosure provides peptides and pharmaceutical compositions thereof. Such peptides can be useful, for example, in treating various human diseases such as immunological diseases. In some embodiments, the peptides are useful as immunotherapeutics for modulating regulatory and effector molecules of the mammalian immune system.

Abstract: This disclosure provides, e.g., novel cells having a modification (e.g., insertion or deletion) in the endogenous CD123 gene. The disclosure also provides compositions, e.g., gRNAs, that can be used to make such a modification.

Abstract: This disclosure provides, e.g., novel cells having a modification (e.g., insertion or deletion) in the endogenous CLL1 gene. The disclosure also provides compositions, e.g., gRNAs, that can be used to make such a modification.

Abstract: Systems and methods for supporting multi-tenancy in a multi-tenant application server environment are provided. A first partition in a multi-tenant server environment can include a first composite and the first composite includes first metadata that is configured to be customized for a first tenant of the first partition. A second partition in the multi-tenant server environment can include a second composite and the second composite includes second metadata that is configured to be customized for a second tenant of the second partition. A global runtime in the multi-tenant server environment can include a global composite and the global composite include global metadata that is configured to be shared by the first partition and the second partition.

Abstract: Systems and methods for supporting multi-tenancy in a multi-tenant application server environment are provided. A first partition in a multi-tenant server environment can include a first composite and the first composite includes first metadata that is configured to be customized for a first tenant of the first partition. A second partition in the multi-tenant server environment can include a second composite and the second composite includes second metadata that is configured to be customized for a second tenant of the second partition. A global runtime in the multi-tenant server environment can include a global composite and the global composite include global metadata that is configured to be shared by the first partition and the second partition.

Abstract: A lamp having a cold cathode field emission plate; an anode plate having a transparent substrate having a first side and a second side; a transparent conductive coating formed on the first side of the transparent substrate; a phosphor layer formed on the transparent conductive coating, and a filter formed on the second side of the transparent substrate; and a voltage source connected across the cathode and the anode plate.

Abstract: A docking station provides supporting functions for portable electronic devices, such as music players, satellite radio receivers, and video game players. The supporting functions may include providing power, an audio amplifier, speakers, and a video or audio display. The docking station includes a base portion and a connector slidably engaged with the base portion for centering the portable electronic device with respect to the base portion. The base portion includes circuitry for processing signals from the portable electronic device. The connector can be attached to a circuit board that is slidably disposed between the base portion and an attachment portion removably connected to the base portion. The docking station can recognize the type of device connected and configure itself to accommodate the requirements of the portable electronic device. The docking station can include a display portion perpendicular to the base portion.

Abstract: A lamp having a cold cathode field emission plate; an anode plate having a transparent substrate having a first side and a second side; a transparent conductive coating formed on the first side of the transparent substrate; a phosphor layer formed on the transparent conductive coating, and a filter formed on the second side of the transparent substrate; and a voltage source connected across the cathode and the anode plate.

Abstract: A method of manufacturing a triode field emission cold cathode device having randomly distributed field emission emitters comprising the steps of providing a substrate (10), depositing a first conductive layer (11) on the substrate, spraying the preceding layer with a random pattern of masking material (20), depositing an insulating layer (13) on the masked preceding layer, depositing a second conductive layer (14) on the insulting layer, and removing the masking material. A triode field emission cold cathode device having randomly distributed field emission emitters is also provided.

Abstract: An assembly of coupling and retention means (10) of a connector (8) for fastening to another complementary connector which is mating with the subject connector (8), and for mounting onto the board on which the connector is seated, includes a coupling device (12) having an internally threaded insert (16) and an integral base (14), and further includes a retention device (20) stamped and formed by a metal blank. The retention device (20) includes at the top a box portion (22) having a space to retainably receive the base (14) of the coupling device (12) therein, and a pair of mounting legs (40) extending downward at the bottom for mounting onto the board. The connector (8) has a cavity (92) at the bottom for reception of the box portion (22) of the retention device (20) therein wherein the coupling device (12) and the retention device (20) are axially aligned with each other and extending in the same direction as that of the contacts ( 81) of the connector (8).