Patents by Inventor Michelle M. Butler

Michelle M. Butler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METABOLICALLY STABLE N-ACYLAMINOOXADIAZOLES USEFUL AS ANTIBACTERIAL AGENTS
    Publication number: 20230109833
    Abstract: The present invention is related to the development of therapeutics and prophylactics for the treatment and/or prevention of bacterial infections in humans and other mammals. A new class of small molecules is disclosed that inhibits the bacterial trans-translation/ribosome rescue mechanism and thus blocks infection of host cells by bacteria. Also disclosed are methods of using the small molecule inhibitors in the treatment/prevention of bacterial infections.
    Type: Application
    Filed: October 13, 2022
    Publication date: April 13, 2023
    Applicants: MICROBIOTIX, INC., THE PENN STATE RESEARCH FOUNDATION
    Inventors: Zachary D. Aron, Steven M. Kwasny, Matthew C. Torhan, Jay P. Barbor, Steven C. Cardinale, Michelle M. Butler, Timothy J. Opperman, Kenneth C. Keiler
  • Metabolically stable N-acylaminooxadiazoles useful as antibacterial agents
    Patent number: 11505533
    Abstract: The present invention is related to the development of therapeutics and prophylactics for the treatment and/or prevention of bacterial infections in humans and other mammals. A new class of small molecules is disclosed that inhibits the bacterial trans-translation/ribosome rescue mechanism and thus blocks infection of host cells by bacteria. Also disclosed are methods of using the small molecule inhibitors in the treatment/prevention of bacterial infections.
    Type: Grant
    Filed: August 21, 2018
    Date of Patent: November 22, 2022
    Assignees: MICROBIOTIX, INC., THE PENN STATE RESEARCH FOUNDATION
    Inventors: Zachary D. Aron, Steven M. Kwasny, Matthew C. Torhan, Jay P. Barbor, Steven C. Cardinale, Michelle M. Butler, Timothy J. Opperman, Kenneth C. Keiler
  • METABOLICALLY STABLE N-ACYLAMINOOXADIAZOLES USEFUL AS ANTIBACTERIAL AGENTS
    Publication number: 20200361882
    Abstract: The present invention is related to the development of therapeutics and prophylactics for the treatment and/or prevention of bacterial infections in humans and other mammals. A new class of small molecules is disclosed that inhibits the bacterial trans-translation/ribosome rescue mechanism and thus blocks infection of host cells by bacteria. Also disclosed are methods of using the small molecule inhibitors in the treatment/prevention of bacterial infections.
    Type: Application
    Filed: August 21, 2018
    Publication date: November 19, 2020
    Applicants: MICROBIOTIX, INC., THE PENN STATE RESEARCH FOUNDATION
    Inventors: Zachary D. Aron, Steven M. Kwasny, Matthew C. Torhan, Jay P. Barbor, Steven C. Cardinale, Michelle M. Butler, Timothy J. Opperman, Kenneth C. Keiler
  • Methods for the purification and aqueous fiber spinning of spider silks and other structural proteins
    Patent number: 7335739
    Abstract: Methods are described for the purification and spinning of recombinant and non-recombinant proteins. Specifically, the lysis of bacteria and purification of silk proteins occur in a single solution of organic acid. Bacterial proteins are hydrolyzed while the silk protein remains intact. Silk proteins remain soluble as they are concentrated into a aqueous-based mixture for fiber spinning.
    Type: Grant
    Filed: April 29, 2003
    Date of Patent: February 26, 2008
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Charlene Mello, Steven Arcidiacono, Michelle M. Butler
  • Method for the purification and aqueous fiber spinning of spider silks and other structural proteins
    Patent number: 6620917
    Abstract: Methods are described for the purification and spinning of recombinant and non-recombinant proteins. Specifically, the lysis of bacteria and purification of silk proteins occur in a single solution of organic acid. Bacterial proteins are hydrolyzed while the silk protein remains intact. Silk proteins remain soluble as they are concentrated into a aqueous-based mixture for fiber spinning.
    Type: Grant
    Filed: January 20, 2000
    Date of Patent: September 16, 2003
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Charlene Mello, Steven Arcidiacono, Michelle M. Butler