Patents by Inventor Michelle M. Wiest

Michelle M. Wiest has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of Assessing Liver Triglyceride Levels Using a Body Fluid Sample
    Publication number: 20200116743
    Abstract: A method of assessing the level of triglycerides in the liver of a subject comprises determining the amount of a first lipid metabolite in a sample from the subject. The sample can be blood, plasma, serum, isolated lipoprotein fraction, saliva, urine, lymph fluid, bile, or cerebrospinal fluid. The first lipid metabolite is a fatty acid present in a lipid class. The lipid class is selected from the group consisting of free fatty acids, total fatty acids (TL), triglycerides (TG), cholesterol esters (CE), phosphatidylcholines (PC), and phosphatidylethanolamines (PE).
    Type: Application
    Filed: August 6, 2019
    Publication date: April 16, 2020
    Inventors: Steven M. Watkins, Michelle M. Wiest, Rebecca A. Baillie
  • Lipidomic approaches to determining drug response phenotypes in cardiovascular disease
    Patent number: 8137977
    Abstract: The present invention concerns the application of lipidomics to statin treatment for disorders such as cardiovascular disorders. Hence, the invention provides, among other things, a method of correlating a lipid profile with a positive or negative response to a statin treatment regimen by obtaining a lipid profile of a sample from a mammalian subject following commencement of the treatment regimen; and correlating the lipid profile in the sample with a positive or negative response to the treatment regimen. The invention further provides a method of correlating a lipid profile with a positive or negative response to a statin treatment regimen by obtaining a lipid profile of a sample from a mammalian subject before commencement of the treatment regimen; and correlating the lipid profile in the sample with a positive or negative response to the treatment regimen.
    Type: Grant
    Filed: October 24, 2008
    Date of Patent: March 20, 2012
    Assignees: Children's Hospital & Research Center at Oakland, Duke University, Lipomics Technologies, Inc., Mayo Foundation for Medical Education and Research
    Inventors: Rima F. Kaddurah-Daouk, Michelle M. Wiest, Steven M. Watkins, Rebecca Ann Baillie, Madhumita Patnaik, K. Ranga Rama Krishnan, Richard M. Weinshilboum, Ronald M. Krauss
  • MARKERS OF NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) AND NON-ALCOHOLIC STEATOHEPATITIS (NASH) AND METHODS OF USE THEREOF
    Publication number: 20100233724
    Abstract: Novel methods for assessing the level of triglycerides in the liver of a subject are described, comprising determining the amount of a lipid metabolite in a sample from a body fluid of the subject. The methods may be used, for example, in diagnosing and monitoring liver disorders such as steatosis, NAFLD and NASH.
    Type: Application
    Filed: August 8, 2007
    Publication date: September 16, 2010
    Inventors: Steven M. Watkins, Michelle M. Wiest, Rebecca A. Baillie
  • METABOLIC MARKERS OF DIABETIC CONDITIONS AND METHODS OF USE THEREOF
    Publication number: 20100197028
    Abstract: Novel methods for assessing the state of a diabetic condition of a subject are described, comprising determining the amount of a metabolite in a sample from a body fluid or tissue of the subject. The methods may be used, for example, in diagnosing and monitoring insulin resistance, prediabetes, or the response to a drug which alters a diabetic condition.
    Type: Application
    Filed: February 22, 2008
    Publication date: August 5, 2010
    Applicant: Tethys Bioscience, Inc.
    Inventors: Steven M. Watkins, Michelle M. Wiest
  • METABOLITE MARKERS FOR WEIGHT MANAGEMENT
    Publication number: 20090221081
    Abstract: The present invention provides methods of using certain metabolite markers for predicting weight development or its related conditions of a subject. The present invention also provides compositions and kits useful for detecting metabolite markers of the present invention.
    Type: Application
    Filed: November 26, 2008
    Publication date: September 3, 2009
    Inventors: Steve M. Watkins, Michelle M. Wiest
  • Lipidomic Approaches to Determining Drug Response Phenotypes in Cardiovascular Disease
    Publication number: 20090197242
    Abstract: The present invention concerns the application of lipidomics to statin treatment for disorders such as cardiovascular disorders. Hence, the invention provides, among other things, a method of correlating a lipid profile with a positive or negative response to a statin treatment regimen by obtaining a lipid profile of a sample from a mammalian subject following commencement of the treatment regimen; and correlating the lipid profile in the sample with a positive or negative response to the treatment regimen. The invention further provides a method of correlating a lipid profile with a positive or negative response to a statin treatment regimen by obtaining a lipid profile of a sample from a mammalian subject before commencement of the treatment regimen; and correlating the lipid profile in the sample with a positive or negative response to the treatment regimen.
    Type: Application
    Filed: October 24, 2008
    Publication date: August 6, 2009
    Inventors: Rima F. Kaddurah-Daouk, Michelle M. Wiest, Steven M. Watkins, Rebecca A. Baillie, Madhumita Patnaik, K. Ranga Rama Krishnan, Richard M. Weinshilboum, Ronald M. Krauss