Patents by Inventor Michelle Mandrekar
Michelle Mandrekar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20070172855Abstract: The present invention relates to methods, kits, and compositions for generating purified RNA samples and purified DNA samples. In particular, the present invention provides methods for generating a purified RNA or DNA sample from a sample containing both DNA and RNA molecules using a binding matrix that preferentially binds DNA or RNA in the presence of an acidic dilution buffer, or using a binding matrix that comprises acid zeolites, as well as compositions and kits for practicing such methods.Type: ApplicationFiled: December 8, 2006Publication date: July 26, 2007Applicant: Promega CorporationInventors: Rex Bitner, Michelle Mandrekar, Paula Brisco
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Publication number: 20070015191Abstract: A network of buoyant particles for clearing lysates of biological material, the network including two or more buoyant particles covalently linked together, wherein the network ranges in size from approximately 30 microns to approximately one centimeter along the network's longest dimension. The buoyant particles may have a silica surface. The network may have a density less than about 1.2 g/cm3. Methods of making the network of buoyant particles and methods of isolating target biological material using buoyant particles or a network of buoyant particles are also described.Type: ApplicationFiled: June 30, 2006Publication date: January 18, 2007Applicant: Promega CorporationInventors: Rex Bitner, Michelle Mandrekar, Don Smith, Douglas White
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Publication number: 20050214753Abstract: Processes are disclosed using the depolymerization of a nucleic acid hybrid to qualitatively and quantitatively analyze for the presence of a predetermined nucleic acid. Applications of those processes include the detection of single nucleotide polymorphisms, identification of single base changes, speciation, determination of viral load, genotyping, medical marker diagnostics, and the like.Type: ApplicationFiled: February 22, 2001Publication date: September 29, 2005Applicant: Promega CorporationInventors: John Shultz, Martin Lewis, Donna Leippe, Michelle Mandrekar, Daniel Kephart, Richard Rhodes, Christine Andrews, James Hartnett, Trent Gu, Ryan Olson, Keith Wood, Roy Welch
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Patent number: 6730479Abstract: Processes are disclosed using the depolymerization of a nucleic acid hybrid to qualitatively and quantitatively analyze for the presence of a predetermined nucleic acid. Applications of those processes include the detection of single nucleotide polymorphisms, identification of single base changes, speciation, determination of viral load, genotyping, medical marker diagnostics, and the like.Type: GrantFiled: February 22, 2001Date of Patent: May 4, 2004Assignee: Promega CorporationInventors: John William Shultz, Martin K. Lewis, Donna Leippe, Michelle Mandrekar, Daniel Kephart, Richard Byron Rhodes, Christine Ann Andrews, James Robert Hartnett, Trent Gu, Ryan J. Olson, Keith V. Wood, Roy Welch
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Patent number: 6653078Abstract: Processes are disclosed using the depolymerization of a nucleic acid hybrid to qualitatively and quantitatively analyze for the presence of predetermined nucleic acid target sequences using a multiplex assay format. Applications of those processes include the detection of single nucleotide polymorphisms, identification of single base changes, speciation, genotyping, medical marker diagnostics, and the like.Type: GrantFiled: February 20, 2001Date of Patent: November 25, 2003Assignee: Promega CorporationInventors: Martin K. Lewis, Daniel Kephart, Richard Byron Rhodes, John William Shultz, Donna Leippe, Michelle Mandrekar, Christine Ann Andrews, James Robert Hartnett, Trent Gu, Keith V. Wood, Roy Welch
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Publication number: 20030203358Abstract: Processes are disclosed using the depolymerization of a nucleic acid hybrid to qualitatively and quantitatively analyze for the presence of a predetermined exogenous nucleic acid. Applications of those processes include the detection of single nucleotide polymorphisms, identification of single base changes, determination of viral load, genotyping, medical marker diagnostics, and the like.Type: ApplicationFiled: February 9, 2001Publication date: October 30, 2003Applicant: Promega CorporationInventors: John William Shultz, Martin K. Lewis, Donna Leippe, Michelle Mandrekar, Daniel Kephart, Richard Byron Rhodes, Christine Ann Andrews, James Robert Hartnett, Trent Gu, Ryan J. Olson, Keith V. Wood, Roy Welch
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Publication number: 20030194699Abstract: Processes are disclosed using the depolymerization of a nucleic acid hybrid to qualitatively and quantitatively analyze for the presence of predetermined nucleic acid target sequences using a multiplex assay format. Applications of those processes include the detection of single nucleotide polymorphisms, identification of single base changes, speciation, genotyping, medical marker diagnostics, and the like.Type: ApplicationFiled: February 20, 2001Publication date: October 16, 2003Applicant: Promega CorporationInventors: Martin K. Lewis, Daniel Kephart, Richard Byron Rhodes, John William Shultz, Donna Leippe, Michelle Mandrekar, Christine Ann Andrews, James Robert Hartnett, Trent Gu, Keith V. Wood, Roy Welch
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Publication number: 20030077621Abstract: Processes are disclosed using the depolymerization of a nucleic acid hybrid to qualitatively and quantitatively analyze for the presence of a predetermined endogenous nucleic acid. Applications of those processes include the detection of single nucleotide polymorphisms, identification of single base changes, spieciation, determination of viral load, genotyping, medical marker diagnostics, and the like.Type: ApplicationFiled: May 20, 2002Publication date: April 24, 2003Applicant: Promega CorporationInventors: John William Shultz, Martin K. Lewis, Donna Leippe, Michelle Mandrekar, Daniel Kephart, Richard Byron Rhodes, Christine Ann Andrews, James Robert Hartnett, Trent Gu, Ryan J. Olson, Keith V. Wood, Roy Welch
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Patent number: 6391551Abstract: Processes are disclosed using the depolymerization of a nucleic acid hybrid to qualitatively and quantitatively analyze for the presence of a predetermined endogenous nucleic acid. Applications of those processes include the detection of single nucleotide polymorphisms, identification of single base changes, speciation, determination of viral load, genotyping, medical marker diagnostics, and the like.Type: GrantFiled: August 25, 1999Date of Patent: May 21, 2002Assignee: Promega CorporationInventors: John William Shultz, Martin K. Lewis, Donna Leippe, Michelle Mandrekar, Daniel Kephart, Richard Byron Rhodes, Christine Ann Andrews, James Robert Hartnett, Trent Gu, Ryan J. Olson, Keith V. Wood, Roy Welch
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Patent number: 6312902Abstract: Processes are disclosed using the depolymerization of a nucleic acid hybrid to qualitatively and quantitatively analyze for the presence of a predetermined nucleic acid. Applications of those processes include the detection of single nucleotide polymorphisms, identification of single base changes, speciation, determination of viral load, genotyping, medical marker diagnostics, and the like.Type: GrantFiled: September 27, 1999Date of Patent: November 6, 2001Assignee: Promega CorporationInventors: John William Shultz, Martin K. Lewis, Donna Leippe, Michelle Mandrekar, Daniel Kephart, Richard Byron Rhodes, Christine Ann Andrews, James Robert Hartnett, Trent Gu, Ryan J. Olson, Roy Welch
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Publication number: 20010031470Abstract: Processes are disclosed using the depolymerization of a nucleic acid hybrid to qualitatively and quantitatively analyze for the presence of a predetermined nucleic acid. Applications of those processes include the detection of single nucleotide polymorphisms, identification of single base changes, speciation, determination of viral load, genotyping, medical marker diagnostics, and the like.Type: ApplicationFiled: February 22, 2001Publication date: October 18, 2001Applicant: Promega CorporationInventors: John William Shultz, Martin K. Lewis, Donna Leippe, Michelle Mandrekar, Daniel Kephart, Richard Byron Rhodes, Christine Ann Andrews, James Robert Hartnett, Trent Gu, Ryan J. Olson, Keith V. Wood, Roy Welch
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Patent number: 6277578Abstract: The detection of enhanced, targeted predetermined nucleic acid sequences in nucleic acid target hybrids, and the various applications of target nucleic acid enhancement are disclosed.Type: GrantFiled: October 29, 1999Date of Patent: August 21, 2001Assignee: Promega CorporationInventors: John William Shultz, Martin K. Lewis, Donna Leippe, Michelle Mandrekar, Christine Ann Andrews, James Robert Hartnett, Roy Welch
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Patent number: 6270973Abstract: Processes are disclosed using the depolymerization of a nucleic acid hybrid to qualitatively and quantitatively analyze for the presence of predetermined nucleic acid target sequences using a multiplex assay format. Applications of those processes include the detection of single nucleotide polymorphisms, identification of single base changes, speciation, genotyping, medical marker diagnostics, and the like.Type: GrantFiled: September 27, 1999Date of Patent: August 7, 2001Assignee: Promega CorporationInventors: Martin K. Lewis, Daniel Kephart, Richard Byron Rhodes, John William Shultz, Donna Leippe, Michelle Mandrekar, Christine Ann Andrews, James Robert Hartnett, Trent Gu, Keith V. Wood, Roy Welch
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Patent number: 6270974Abstract: Processes are disclosed using the depolymerization of a nucleic acid hybrid to qualitatively and quantitatively analyze for the presence of a predetermined exogenous nucleic acid. Applications of those processes include the detection of single nucleotide polymorphisms, identification of single base changes, determination of viral load, genotyping, medical marker diagnostics, and the like.Type: GrantFiled: September 27, 1999Date of Patent: August 7, 2001Assignee: Promega CorporationInventors: John William Shultz, Martin K. Lewis, Donna Leippe, Michelle Mandrekar, Daniel Kephart, Richard Byron Rhodes, Christine Ann Andrews, James Robert Hartnett, Trent Gu, Ryan J. Olson, Keith V. Wood, Roy Welch
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Patent number: 6268146Abstract: Mass spectrometric, absorbance spectroscopic and fluorescence spectroscopic processes are disclosed to detect the depolymerization of a nucleic acid hybrid in order to qualitatively and quantitatively assay for the presence of a predetermined nucleic acid target. Applications of those processes include the detection of single nucleotide polymorphisms, identification of single base changes, speciation, determination of viral load, genotyping, medical marker diagnostics, and the like, including multiplexed assays.Type: GrantFiled: November 22, 1999Date of Patent: July 31, 2001Assignee: Promega CorporationInventors: John William Shultz, Martin K. Lewis, Michelle Mandrekar, Donna Leippe, Roderick R. Smith, Jr., Roy Welch
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Patent number: 6235480Abstract: Processes are disclosed using the depolymerization of a nucleic acid hybrid to qualitatively and quantitatively analyze for the presence of a predetermined nucleic acid. Applications of those processes include the detection of single nucleotide polymorphisms, identification of single base changes, speciation, determination of viral load, genotyping, medical marker diagnostics, and the like.Type: GrantFiled: July 21, 1999Date of Patent: May 22, 2001Assignee: Promega CorporationInventors: John William Shultz, Martin K. Lewis, Donna Leippe, Michelle Mandrekar, Daniel Kephart, Richard Byron Rhodes, Christine Ann Andrews, James Robert Hartnett, Trent Gu, Ryan J. Olson, Keith V. Wood, Roy Welch
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Patent number: 6159693Abstract: This invention discloses methods for detecting specific nucleic acid sequences, interrogating the identity of a specific base within a sequence, and assaying endonuclease and exonuclease activity. DNA or RNA probes are hybridized to target nucleic acid sequences. Probes that are complementary to the target sequence at each base are depolymerized, while probes which differ from the target at the interrogation position are not depolymerized. The nucleic acid detection systems utilize the pyrophosphorolysis reaction catalyzed by various polymerases to produce deoxyribonucleoside triphosphates or ribonucleoside triphosphates. dNTPs are transformed to ATP by the action of NDPK. The ATP produced by these reactions is detected by luciferase or NADH based detection systems.Type: GrantFiled: February 18, 1999Date of Patent: December 12, 2000Assignee: Promega CorporationInventors: John W. Shultz, Michelle A. Mandrekar, Donna M. Leippe, Martin K. Lewis, Lisa S. Nelson